Astros vs. Cubs Odds & Betting Predictions - May 22, 2026

Astros at Cubs

6:20 pm • Apple TV+
4 - 2
Starting Pitchers
pitcherteameraw-l
Jameson Taillon logoJ.TaillonChicago Cubs logo5.212-4
Spencer Arrighetti logoS.ArrighettiHouston Astros logo1.326-1

Astros at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
22-31
+1.5
+1.5-186
o7+100
+124
Cubs
29-23
u7.5
-1.5+158
u7-120
-149
location pinFriday 6:20 p.m.
May 22, 2026
Wrigley FieldChicago
Astros vs. Cubs Expert Picks
Sean Zerillo
Sean Zerillo
Last 30d: 176-147-12 (+5.0u)
Over 7+105
0.25u
Small to -105. Can target Over 6.5 or 4.5/5 live
💰🦡 Jake
💰🦡 Jake
Last 30d: 72-75-6 (+10.3u)
Under 3.5 (F5)+104
1.25u
Payoff Pitch Podcast
Payoff Pitch Podcast
Last 30d: 81-103-10 (+6.1u)
Y.Alvarez o0.5 HR+470
0.25u
@cowhitchurch ⭐️ https://myaction.app/mcSZfWMQl3b
Frank Ammirante
Frank Ammirante
Last 30d: 237-262-10 (-13.8u)
S.Arrighetti o16.5 Outs-108
1.08u
Under 7.5-130
1u
Adam Kaufman
Adam Kaufman
Last 30d: 37-46-0 (-14.3u)
HOU +125
1.25u
Matt Trollo
Matt Trollo
Last 30d: 52-53-5 (+0.8u)
Over 7-110
0.55u
(DK) Bucking the weather trends here because both pitchers have xERAs within 0.1 of 5.00 and SIERAs within 0.17 of 4.50. Both offenses > 110 wRC+ Hm/Rd & > 105 v RHP. Both proj. Lus > 110 v RHP since LY. Two solid defenses (CHC maybe beset), but also a pair of bottom third of the league pen estimators L30 days (HOU 2nd worst).

Astros vs. Cubs Previews & Analysis

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    Our 4 MLB Best Bets for Friday Night

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    May 22, 2026 UTC
  • Adam Trigger's Triple-A Baseball Picks for Friday article feature image

    Adam Trigger's Triple-A Baseball Picks for Friday

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  • Astros vs Cubs: A Hitter's Dream article feature image

    Astros vs Cubs: A Hitter's Dream

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  • Wrigley Field Wind Report: Cubs vs Astros article feature image

    Wrigley Field Wind Report: Cubs vs Astros

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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Cubs Public Betting Percentages

Away Logo

Astros

Public

31%

Bets%

69%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs
21-3112-169-1514-207-11
Astros
22-3111-1511-164-1118-19

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs
28-2414-1414-1017-1711-7
Astros
27-22-416-9-111-13-39-617-16-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs
29-2318-1011-1321-138-10
Astros
22-3112-1410-175-1017-20

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
May 20thMILL 0-5+1.5 LU 6.5MIL -112
May 19thMILL 2-5+1.5 LU 7.5MIL +103
May 18thMILL 3-9-1.5 LO 10.5MIL -161
May 17th@CWSL 8-9-1.5 LO 9CWS -131
May 16th@CWSL 3-8-1.5 LO 8.5CWS -108

Astros vs. Cubs Injury Updates

Astros Injuries

  • Lance McCullers
    SP

    Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.

    Out

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Astros vs. Cubs Box Score
Astros Player Stats
Projected
PITCHERPCIPKER
Spencer Arrighetti logoRS.Arrighetti, P89550
Steven Okert logoLS.Okert, P60.102
Enyel De Los Santos logoRE.De Los Santos, P191.210
Bryan Abreu logoRB.Abreu, P140.200
Bryan King logoLB.King, P171.100
HITTERSH-ABRHRRBI
Jeremy Pena logo1J.Pena, SS1-5000
Isaac Paredes logo2I.Paredes, 3B1-4100
Yordan Alvarez logo3Y.Alvarez, DH1-3000
Christian Walker logo4C.Walker, 1B1-5100
Jake Meyers logo5J.Meyers, CF1-4000
Braden Shewmake logo6B.Shewmake, 2B0-1100
Brice Matthews logo6B.Matthews, PH1-2001
Brice Matthews logo6B.Matthews, 2B1-2001
Nick Allen logo6N.Allen, 2B0-0000
Cam Smith logo7C.Smith, RF1-4000
Zach Cole logo8Z.Cole, LF0-4001
Christian Vazquez logo9C.Vazquez, C2-4112
Cubs Player Stats
Projected
PITCHERPCIPKER
Jameson Taillon logoRJ.Taillon, P904.254
Hoby Milner logoLH.Milner, P80.100
Ethan Roberts logoRE.Roberts, P32220
Jacob Webb logoRJ.Webb, P15120
Phil Maton logoRP.Maton, P22110
HITTERSH-ABRHRRBI
Nico Hoerner logo1N.Hoerner, 2B0-4000
Michael Busch logo2M.Busch, 1B0-3000
Alex Bregman logo3A.Bregman, 3B1-3000
Ian Happ logo4I.Happ, LF1-5000
Seiya Suzuki logo5S.Suzuki, RF0-4000
Michael Conforto logo6M.Conforto, DH0-2000
Miguel Amaya logo6M.Amaya, PH1-1100
Miguel Amaya logo6M.Amaya, DH1-1100
Moises Ballesteros logo6M.Ballesteros, PH0-1000
Moises Ballesteros logo6M.Ballesteros, DH0-1000
Carson Kelly logo7C.Kelly, C0-3000
Pete Crow-Armstrong logo8P.Crow-Armstrong, CF1-2112
Dansby Swanson logo9D.Swanson, SS0-4000

Astros vs. Cubs Odds Comparison

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Astros at Cubs Team Totals

MatchupOverUnder
Astros
22-31
N/A
N/A
Cubs
29-23
N/A
N/A