Astros vs. Cubs Odds & Betting Predictions - May 22, 2026

Astros at Cubs

6:20 pm • Apple TV+

Houston Astros

22-31

4 - 2

Chicago Cubs

29-23

pitcher		team	era	w-l
J.Taillon			5.21	2-4
S.Arrighetti			1.32	6-1

MatchupOpenSpreadTotalMoneyline
Astros 22-31	+1.5	+1.5-186	o7+100	+124
Cubs 29-23	u7.5	-1.5+158	u7-120	-149

Friday 6:20 p.m.

May 22, 2026

Wrigley FieldChicago

Over 7+105

0.25u

Small to -105. Can target Over 6.5 or 4.5/5 live

Under 3.5 (F5)+104

1.25u

Y.Alvarez o0.5 HR+470

0.25u

@cowhitchurch ⭐️ https://myaction.app/mcSZfWMQl3b

S.Arrighetti o16.5 Outs-108

1.08u

Under 7.5-130

HOU +125

1.25u

Over 7-110

0.55u

(DK) Bucking the weather trends here because both pitchers have xERAs within 0.1 of 5.00 and SIERAs within 0.17 of 4.50. Both offenses > 110 wRC+ Hm/Rd & > 105 v RHP. Both proj. Lus > 110 v RHP since LY. Two solid defenses (CHC maybe beset), but also a pair of bottom third of the league pen estimators L30 days (HOU 2nd worst).

Our 4 MLB Best Bets for Friday Night
Action Network Staff•
May 22, 2026 UTC
Adam Trigger's Triple-A Baseball Picks for Friday
Adam Trigger•
May 22, 2026 UTC
Astros vs Cubs: A Hitter's Dream
Jon Anderson•
May 22, 2026 UTC
Wrigley Field Wind Report: Cubs vs Astros
Tanner McGrath•
May 22, 2026 UTC

See more MLB Coverage

No props found

MLB Public Betting

Cubs are 0-5 in their last 5 games.
Cubs are 0-5 in their last 5 games against the spread
Cubs are 9-15 in their road games against the spread
The totals have gone OVER in 1 of Cubs' last 5 games
The totals have gone OVER in 14 of Cubs' 28 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Cubs	21-31	12-16	9-15	14-20	7-11
Astros	22-31	11-15	11-16	4-11	18-19

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Cubs	28-24	14-14	14-10	17-17	11-7
Astros	27-22-4	16-9-1	11-13-3	9-6	17-16-4

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Cubs	29-23	18-10	11-13	21-13	8-10
Astros	22-31	12-14	10-17	5-10	17-20

date	opponent	score	spread	over/under	moneyline
May 20th	MIL	L 0-5	+1.5 L	U 6.5	MIL -112
May 19th	MIL	L 2-5	+1.5 L	U 7.5	MIL +103
May 18th	MIL	L 3-9	-1.5 L	O 10.5	MIL -161
May 17th	@CWS	L 8-9	-1.5 L	O 9	CWS -131
May 16th	@CWS	L 3-8	-1.5 L	O 8.5	CWS -108

Lance McCullers
SP
Lance McCullers Jr. has been scratched Tuesday. Jason Alexander will start.
Out

Tyler Austin
1B
Austin is out with knee
Out
Justin Steele
SP
Steele is out with elbow
Out
Jordan Wicks
SP
Wicks is out with arm
Out

See more MLB Injuries

PITCHER	PC	IP	K	ER
RS.Arrighetti, P	89	5	5	0
LS.Okert, P	6	0.1	0	2
RE.De Los Santos, P	19	1.2	1	0
RB.Abreu, P	14	0.2	0	0
LB.King, P	17	1.1	0	0

HITTERS	H-AB	R	HR	RBI
1J.Pena, SS	1-5	0	0	0
2I.Paredes, 3B	1-4	1	0	0
3Y.Alvarez, DH	1-3	0	0	0
4C.Walker, 1B	1-5	1	0	0
5J.Meyers, CF	1-4	0	0	0
6B.Shewmake, 2B	0-1	1	0	0
6B.Matthews, PH	1-2	0	0	1
6B.Matthews, 2B	1-2	0	0	1
6N.Allen, 2B	0-0	0	0	0
7C.Smith, RF	1-4	0	0	0
8Z.Cole, LF	0-4	0	0	1
9C.Vazquez, C	2-4	1	1	2

PITCHER	PC	IP	K	ER
RJ.Taillon, P	90	4.2	5	4
LH.Milner, P	8	0.1	0	0
RE.Roberts, P	32	2	2	0
RJ.Webb, P	15	1	2	0
RP.Maton, P	22	1	1	0

HITTERS	H-AB	R	HR	RBI
1N.Hoerner, 2B	0-4	0	0	0
2M.Busch, 1B	0-3	0	0	0
3A.Bregman, 3B	1-3	0	0	0
4I.Happ, LF	1-5	0	0	0
5S.Suzuki, RF	0-4	0	0	0
6M.Conforto, DH	0-2	0	0	0
6M.Amaya, PH	1-1	1	0	0
6M.Amaya, DH	1-1	1	0	0
6M.Ballesteros, PH	0-1	0	0	0
6M.Ballesteros, DH	0-1	0	0	0
7C.Kelly, C	0-3	0	0	0
8P.Crow-Armstrong, CF	1-2	1	1	2
9D.Swanson, SS	0-4	0	0	0