Eat your heart out, Big Monday! Wednesday’s college basketball slate is bananas. Twelve top 25 teams are in action, headlined by No. 1 Virginia vs. Georgia Tech, No. 3 Villanova vs. DePaul, and No. 5 Duke vs. Louisville. The Cavaliers, Wildcats and Blue Devils will each face an unranked opponent coming off a loss. Let’s take a look at how savvy bettors exploit these matchups by using a Pro System from Bet Labs.

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