Duke vs. Virginia Odds & Betting Predictions - December 7, 2025

Hedging Duke 15/1 Ticket - Wynn LV

The college football world spent most of the season waiting for the other shoe to drop when it came to the Wahoos. Surely, a team that started 11-23 under Tony Elliott in his first three seasons couldn’t really compete for an ACC title, right? Some call it luck, others call it being clutch, but what we know is that Virginia is nails in tight ball games. The Cavaliers won three straight games this season by three points or less. Their only loss since early September came by seven to Wake Forest in a game in which Chandler Morris, UVA’s QB1, was knocked out with a head injury. In games that Morris has started and finished, UVA is 10-1 with its lone blemish coming to NC State in a shootout, 35-31. Duke, meanwhile, backed its way into the ACC Title Game on the fifth tiebreaker (combined win percentage of ACC opponents). The Blue Devils went 3-3 down the stretch, allowing 29 points per game to their final six opponents. And in their head-to-head meeting with this very same Virginia team, the Blue Devils got blasted 34-17 while being outgained by 285 yards. At one point in the fourth quarter, it was 31-3 UVA. Simply put, it was one of the worst beatdowns the ACC produced all season long. Sportsbooks are giving the Blue Devils a puncher’s chance because of their offense and Darian Mensah. When they protect him, he’s a big play triggerman. Duke finished 11th in big play creation, with 31 plays of 30+ yards from scrimmage (3rd-most in the ACC). So, how did UVA slow them down in their first meeting? With a nasty pass rush (4 sacks) and great situational playcalling by defensive coordinator John Rudzinski. Duke was just 4-for-15 on third downs, and the Blue Devils turned it over on downs twice, including once inside the UVA ten-yard line. I’ll bank on a repeat performance in Charlotte from the Cavs.