Cardinals vs. 49ers Betting Guide: Odds, Picks, Promos and More

Cardinals vs. 49ers Betting Guide: Odds, Picks, Promos and More article feature image
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Thearon W. Henderson/Getty Images. Pictured: Nick Bosa.

Cardinals vs. 49ers Odds

Cardinals Odds
+6.5 [BET NOW]
49ers Odds
-6.5 [BET NOW]
Over/Under
48.5 [BET NOW]
Kickoff
4:25 p.m. ET
TV
FOX

Odds as of Saturday night and via BetMGM. Get an INSTANT $500 deposit match at BetMGM today or see more offers and reviews for the best online sportsbooks.


The 2020 NFL season is finally here!

The San Francisco 49ers begin the follow-up to their Super Bowl run with a Week 1 matchup against the Arizona Cardinals.

Whether you’re just looking for the latest odds, the top picks or where/how you can get action on Sunday’s matchup, we have you covered with all that information below.

Cardinals vs. 49ers Pick

Cardinals +7, Cardinals ML +255 

Our analyst Raheem Palmer anticipates a high-scoring game between these teams and thinks the defending NFC champs might be overvalued. Read his full preview of Cardinals-49ers here.

How & Where To Bet On Cardinals-49ers

You can find reviews of the best online sportsbooks in your states, their latest promos and more in this hub.

Legal online sports betting is currently available in the following states:

And here are some of the top online sportsbooks:

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