Thursday Night Football Odds, Picks & 49ers vs. Cardinals Betting Predictions

Thursday Night Football Odds, Picks & 49ers vs. Cardinals Betting Predictions article feature image

Kyle Terada-USA TODAY Sports. Pictured: Emmanuel Sanders

  • The San Francisco 49ers take their undefeated record on the road to face the Arizona Cardinals on Thursday Night Football.
  • Use this cheat sheet as your one-stop shop for all of our Thursday Night Football betting content.

49ers at Cardinals Odds, Picks & Predictions

  • Odds: 49ers -10
  • Over/Under: 43
  • Kickoff: 8:20 p.m. ET
  • TV Channel: FOX, NFL Network, Amazon Prime

Odds as of Thursday afternoon and via PointsBet, where Action Network users can access an exclusive promotion to get a 200% deposit match (deposit $50, bet with $150).

Thursday Night Football Betting Guide

Our analysts and experts break down the most important angles of this game.

Here’s an excerpt, but you can read the full story here.

The 49ers have pounded the ball down the throat of every opponent they’ve faced this season. They’re averaging 181.1 rushing yards per game, second only to Baltimore. They eviscerated the Carolina run defense last week, totaling 232 rushing yards and 6.1 yards per carry while scoring five rushing touchdowns.

San Francisco (7-0) is one of two undefeated teams left and is a perfect 4-0 on the road heading into Arizona to face a Cardinals defense that ranks 26th in Football Outsiders’ run defense DVOA.

Read our full betting breakdown for 49ers-Cardinals.

Our Favorite 49ers vs. Cardinals Picks

Our staff breaks down how they’re betting this Thursday Night Football spread. Here are their picks.

How Pros Are Betting TNF

Sharp bettors have been hitting the over/under since it opened. Here’s how they’re moving it.

Best Prop Bets

  • Marquise Goodwin’s Receptions
  • Kenyan Drake’s Receptions
  • Kyle Murray’s Passing TDsThese are the best player prop bets for Thursday night according to our tools. Here’s how to bet all three.

PRO System Trends

There are two historical betting trends supporting one of these two teams. PJ Walsh explains which one.

Fantasy Football Start/Sit Decisions

Start Kenyan Drake? Sit Emmanuel Sanders? Sean Koerner runs through all the key lineup decisions for TNF.

DFS Showdown Slate

Cash game strategy. Core GPP plays. Stacks. Chris Raybon breaks down how to play the single-game slate.

TNF Matchup Breakdown

Evan Silva of Establish The Run helps fantasy players and bettors alike understand the game at the deepest level. Read his breakdown for tonight.

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