49ers vs. Giants Betting Odds & Opening Line: San Francisco Again Favored in New Jersey (Sept. 27)

49ers vs. Giants Betting Odds & Opening Line: San Francisco Again Favored in New Jersey (Sept. 27) article feature image
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Adam Bettcher/Getty Image. Pictured: Jimmy Garoppolo

49ers vs. Giants Odds

49ers Odds -4 [BET NOW]
Giants Odds +4 [BET NOW]
Moneylines -210/+170 [BET NOW]
Over/Under 42 [BET NOW]
Time 1:00 p.m. ET
TV FOX

Odds as of Sunday night and via DraftKings. Get up to a $1,000 sign-up bonus at DraftKings today or see more offers and reviews for the best online sportsbooks.


Opening Line

Injuries are the early story for this NFC matchup between the New York Giants and San Francisco 49ers, who will be playing at MetLife Stadium for the second consecutive week. The 49ers beat the New York Jets here 31-13 last Sunday, covering the spread as 7-point road favorites despite losing a few key players to injury in the first half, including starting quarterback Jimmy Garoppolo.

San Francisco opened as a 6.5-point favorite versus the other New York team, but has already dropped to -4 at most sportsbooks like DraftKings, with injuries remaining a huge concern. In addition to Garoppolo (ankle), the 49ers saw running back Raheem Mostert (knee) and defensive end Nick Bosa (knee) also go down. Bosa could be lost for the season with a torn ACL.

The Giants did not escape Week 2 unscathed either after losing 17-13 to the Chicago Bears as consensus 5-point road underdogs. While New York did cover the spread, the team may have lost running back Saquon Barkley to a torn ACL, as well.

Before making any bets, check out our free NFL injuries and NFL odds pages, and find out how the loss of those players could impact the opening lines.

You can also check out our new PRO Report tool to get signals for sharp action, power rating discrepancies, betting system matches and more for every NFL game.

Where to Bet This Game

If you’re in a state with legal sports betting, you’ve got plenty of options.

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