Broncos-49ers Betting Preview: Will Denver Cover as a Popular Road Favorite?

Betting odds: Denver Broncos at San Francisco 49ers

• Spread: Broncos -3.5
• Over/Under: 45.5
• Time: 4:05 p.m. ET
• TV channel: CBS

Betting market: Nearly 70% of bets are on the Broncos at the time of writing. The line had initially moved in their favor in a big way, going from -4.5 to -6. But with news that Broncos wide receiver Emmanuel Sanders (torn Achilles) will miss the rest of the season, they’ve since dropped all the way to -4 (see live data here).

Three Sports Insights’ Bet Signals came in on the 49ers on Wednesday afternoon, but if you think Sanders (or any wide receiver) is worth two points, you’re wrong.

The total has gone from 44 to 45.5 since opening behind about 70% of bets the over. — Mark Gallant

Trends to know: The Broncos beat the Bengals last week, 24-10, while the 49ers lost, 43-16, to the Seahawks.

A majority of spread tickets are on Denver following each team’s recent performance.

But since 2003, teams that won their previous game by 14 or more points and are getting a majority of bets in their next game against an opponent that lost its previous game by 14 or more points have gone 82-102-3 (45%) against the spread. — John Ewing