Lions vs. Cardinals Odds, Picks, Cheat Sheet, More

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USA Today Sports. Pictured: Kyler Murray

Lions at Cardinals Betting Odds

  • Odds: Lions -2.5
  • Total: 46
  • Time: 4:25 p.m. ET
  • TV Channel: FOX

All odds above are as of Friday and via PointsBet.

Kyler Murray might’ve gone No. 1 overall in the 2019 draft, but his NFL career is starting with little fanfare — at least according to the betting community.

Not only are the Cards home underdogs against a Lions team that went 6-10 last season, but they’re also the second-least popular bet on the entire slate at the time of writing (23% of tickets, according to our proprietary data).

You’ll find all our coverage of this game below, from our comprehensive betting guide to Sean Koerner’s projected odds and more.

Lions at Cardinals Betting Guide, Picks

Our analysts and experts break down the most important angles of this game.

Here’s an excerpt, but you can read the full thing here.

First Patrick Peterson got suspended for the first six games of the season, then Robert Alford went on IR with a leg injury. That leaves the Cardinals to start two players who have never played an NFL snap — Byron Murphy, the 33rd overall pick of this year’s draft, and Jones, a 2018 undrafted free agent — alongside Tramaine Brock, a 31-year-old journeyman who ranked 80th among corners last season in Pro Football Focus’ coverage grades.

The Lions’ passing game should feast.

See our full betting breakdown for Lions-Cardinals here.

Sean Koerner’s Projected Lions-Cardinals Odds

Sean Koerner uses his NFL Power Ratings to project a spread and total for Sunday’s matchup. See whether he thinks Detroit should be 2.5-point favorites on the road.

Lions-Cardinals Prop Bets

NFL player props offer tremendous value every week. Mike Randle analyzes Cardinals WR Christian Kirk’s receptions prop.

Pick ‘Em Confidence Rating

Sean Koerner ranks every straight-up and against-the-spread pick for pools in his Pick ‘Em Confidence Ratings.

See where the Lions and Cardinals rank.

Survivor Pool Recommendations

Should you roll with either Detroit or Arizona to open the season? Our NFL simulations reveal the best Week 1 survivor pool picks.

Rovell’s Vegas Report

Kyler Murray hasn’t generated much betting hype yet. Darren Rovell spoke to bookmakers about the betting action on this game.