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NFL Odds & Picks for Packers vs. 49ers: The Big Thursday Night Football Betting Edge

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Photo by Jim McIsaac/Getty Images. Pictured: Nick Mullens #4 of the San Francisco 49ers

The San Francisco 49ers, who were already riddled with injury issues, got hit even harden when a handful of key players tested positive for COVID-19 and will not play tonight against the Green Bay Packers.

Unsurprisingly, Thursday Night Football odds have swung dramatically in response, with Green Bay stretching from a 2.5-point favorite on Monday up to -7.5.

Clearly, the shorthanded Niners face an uphill battle against the Packers, but can they cover the 7.5-point spread? Or should bettors expect a blowout victory from Green Bay?

Using our PRO Projections, let’s look at tonight’s 49ers vs. Packers Thursday Night Football matchup, which provides one of the biggest betting edges of Week 9.

NFL Picks: Packers vs. 49ers

Although the Packers vs. 49ers spread has ballooned to Green Bay -7.5, our projections peg this line at -3.9, showing a clear market overreaction to San Fran’s injury and COVID issues.

Snagging the 49ers at +7.5 with a projected line of +3.9 represents a 5.4% edge and gets an B rating for those willing to make the contrarian play on San Francisco.

PRO Projection Pick: 49ers +7.5

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