Week 5 NFL Odds: Spreads & Over/Unders for Every Game

Week 5 NFL Odds: Spreads & Over/Unders for Every Game article feature image
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USA Today Sports. Pictured: Dwayne Haskins

  • Find Week 5 NFL odds for every game below, featuring spreads and over/unders.
  • See how are the biggest betting favorites and which matchups have the highest totals.

The Dolphins' massive double-digit spreads have been the highlight of every week. (Update: They've failed to cover three straight.) But with Miami one of the two teams on bye, there's another big underdog headlining this week's odds.

The Washington Redskins got beat, 24-3, by the Daniel Jones-led Giants on Sunday. Now after Case Keenum was benched for Dwayne Haskins, Washington is a 14.5-point home dog against the Patriots.

You'll find spreads and over/unders for every Week 5 game outlined below.


Odds as of Monday morning and via PointsBet, where Action Network users get an exclusive 200% deposit match (deposit $50, bet with $150).


Week 5 NFL Odds: Spreads & Over/Unders

Rams at Seahawks

  • Odds: Seahawks -1
  • Over/Under: 49
  • Time: 8:20 p.m. ET on Thursday
  • TV Channel: NFL Network

The Rams were 3-point favorites when the lookahead lines opened at PointsBet last Tuesday.

Jets at Eagles

  • Odds: Eagles -14
  • Over/Under: 44.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: CBS

The lookahead spread was off the board last week.

Buccaneers at Saints

  • Odds: Saints -4.5
  • Over/Under: 47.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: FOX

Identical to the lookahead line posted last week.

Jaguars at Panthers

  • Odds: Panthers -3.5
  • Over/Under: 41
  • Time: 1 p.m. ET on Sunday
  • TV Channel: CBS

The Panthers are now 2-0 without Cam Newton. Jacksonville QB Gardner Minshew has shown some magic, as well, with two consecutive wins.

Jets at Eagles

  • Odds: Eagles -14
  • Over/Under: 44.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: CBS

This lookahead line was off-the-board early last week due to the Jets' QB uncertainty. This 14-point spread is indicating that the market does not believe Sam Darnold will play.

Vikings at Giants

  • Odds: Vikings -5
  • Over/Under: 45
  • Time: 1 p.m. ET on Sunday
  • TV Channel: FOX

The Vikings got downgraded a bit after losing to the Bears on Sunday. PointsBet's lookahead line had this at Vikings -6.

Falcons at Texans

  • Odds: Texans -5
  • Over/Under: 49
  • Time: 1 p.m. ET on Sunday
  • TV Channel: FOX

This line moved 1.5 points from PointsBet's lookahead number of Texans -3.5. Both teams are coming off a loss, but Atlanta looked particularly uninspiring in a 14-point home loss to the Titans.

Buccaneers at Saints

  • Odds: Saints -4.5
  • Over/Under: 47.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: FOX

Zero change from the lookahead spread in this game.

Bills at Titans

  • Odds: Titans -2.5
  • Over/Under: 38.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: CBS

Zero change from the lookahead spread in this game.

Cardinals at Bengals

  • Odds: Bengals -4.5
  • Over/Under: 48.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: FOX

Not much change from PointsBet's lookahead line, which was Bengals -4.

Patriots at Redskins

  • Odds: Patriots -15
  • Over/Under: 44
  • Time: 1 p.m. ET on Sunday
  • TV Channel: CBS

This lookahead line was off the board last week due to the Redskins' QB uncertainty. It looks like rookie Dwayne Haskins will get his first career start over the benched Case Keenum.

Ravens at Steelers

  • Odds: Ravens -4
  • Over/Under: 42.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: CBS

Coming off a blowout home loss to the Browns, Baltimore got downgraded a bit compared to PointsBet's lookahead line. The Ravens opened -4.5 in the early, early market.

Bears at Raiders

  • Odds: Bears -5.5
  • Over/Under: 41.5
  • Time: 1 p.m. ET on Sunday
  • TV Channel: FOX

Note: Bears-Raiders odds via the Westgate Las Vegas Superbook.

Broncos at Chargers

  • Odds: Chargers -6.5
  • Over/Under: 44
  • Time: 4:05 p.m. ET on Sunday
  • TV Channel: CBS

Zero change from the lookahead line posted last week.

Packers at Cowboys

  • Odds: Cowboys -3.5
  • Over/Under: 47
  • Time: 4:25 p.m. ET on Sunday
  • TV Channel: FOX

The Cowboys lost in a big spot on Sunday Night Football — and yet, the market is giving them more respect than PointsBet's lookahead line of Cowboys -3. The Packers will be rested coming off a Thursday Night Football loss to the Eagles.

Colts at Chiefs

  • Odds: Chiefs -10
  • Over/Under: 57
  • Time: 8:20 p.m. ET on Sunday
  • TV Channel: NBC

Huge move from Chiefs -7.5 on PointsBet's lookahead line. The Colts lost outright as 6-point home favorites to the lifeless Raiders, while the Chiefs completed a last-minute comeback to beat the Lions on the road.

Browns at 49ers

  • Odds: 49ers -3
  • Over/Under: 47.5
  • Time: 8:15 p.m. ET on Monday
  • TV Channel: ESPN

The Browns pulled off a big road upset over the Ravens — and yet the market is giving them less respect here compared to PointsBet's lookahead line, which was 49ers -2. San Fran is coming off a bye.

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