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Cardinals vs. Seahawks Odds & Picks: How To Bet The Thursday Night Football Spread


MSA/Icon Sportswire via Getty Images. Pictured: Kyler Murray, Christian Kirk, DeAndre Hopkins

Cardinals vs. Seahawks Picks

Cardinals +3
Seahawks -2.5
Odds as of early Thursday afternoon. Compare real-time odds to find the best line.

Kyler Murray and the Arizona Cardinals pulled out the overtime victory over Russell Wilson and the Seattle Seahawks in their first meeting of the season. Now the Seahawks play host to the Cardinals for the second matchup on Thursday Night Football as 2.5- to 3-point favorites.

So where’s the betting value on this NFC West showdown? Our staff presents cases for both sides of the spread.

Cardinals +3

Sean Koerner: The Seahawks defense has time to right the ship over the long term, but in the meantime, they’ll have their hands full with Kyler Murray and the Cardinals.

Murray destroys zone coverage — he has the third-highest success rate against it in 2020 (per Sports Info Solutions), and guess which defense plays zone at one of the highest rates in the NFL? Yes, the Seahawks. Murray carved up the Seattle defense for 360 passing yards and three touchdowns as well as 14 carries for 67 yards and a rushing touchdown in the Cardinals’ 37-34 win over the Seahawks in Week 7.

Usually, the Seahawks can overcome poor defensive play by leaning on Russell Wilson. Unfortunately, that hasn’t been true lately — he’s in the middle of a funk, having turned the ball over seven times over their past two games.

Overall, Arizona is getting Seattle at the right time. I like the Cardinals getting +3.

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Matthew Freedman: The football gods are good. At long last, we have a Thursday Night Football game actually worth watching.

Based on their 37-34 win over the Seahawks in October — as well as their 27-13 road win over the Seahawks in Week 16 of 2019 — we know the Cardinals can compete. And in this second divisional game between two good teams, anything more than a field goal feels like too much.

Historically, Cardinals head coach Kliff Kingsbury has provided a strong return on investment (ROI) in two distinct situations against the spread (ATS).

  • As Underdog: 12-4-2 ATS | 41.3% ROI
  • On Road: 8-2-2 ATS | 47% ROI

And when those two situations have overlapped, Kingsbury’s Cardinals have gone 7-1-2 ATS (55.8% ROI) as road dogs according to our Bet Labs data. Overall, he’s a respectable 14-9-2 ATS (18.3% ROI).

His Cardinals consistently over perform. I like them to +3 (-110).

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Seahawks -2.5

Brandon Anderson: Buckle up, it’s gonna be a wild ride.

We already got this exact matchup in a primetime game less than a month ago, and now we get Kyler vs. Russ on national television again — #blessed.

The last matchup was a doozy. Seattle came out and dominated early in the desert, leading 20-7 a couple minutes before halftime. Then things started to get wild. Seventeen (!) points were scored in the final 74 seconds of the half, then the fourth quarter got wonky again. The Cardinals battled all the way back and hit a field goal on the final play to send it to overtime, then kicked another long field goal with 20 seconds left in overtime to steal the win.

The Cardinals love stealing wins lately. They stole another one last week with the Hail Murray to edge out Buffalo — a beautiful Murray bomb that DeAndre Hopkins snagged over three Bills defenders.

But how long can the Cards keep catching all the breaks?

Look at everything they needed to go their way last time to get the win. They hit those two last-second field goals and got a few key penalties to fall their way. Seattle recorded 78 penalty yards, and Wilson threw an uncharacteristic three interceptions, including the would-be pick-six that was chased down by D.K. Metcalf to save the game.

It’s just too much to expect Arizona to catch so many breaks this time.

The Cardinals probably won’t get three more Wilson picks, another slew of Seahawks penalties, and multiple late collapses at the end of each half. Add in an inevitable adrenaline letdown after the wild Hail Murray win and the fact that this one is in Seattle, and I have to side with Russ over Kyler.

Seattle needs to get their season back on the right track, and they’ll find a way late.

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