Panthers vs. 49ers Betting Odds, Picks & Predictions

Panthers vs. 49ers Betting Odds, Picks & Predictions article feature image

Jeremy Brevard-USA TODAY Sports. Pictured: Christian McCaffrey

  • We cover every actionable angle of the Carolina Panthers at San Francisco 49ers.
  • You can find betting odds, expert picks, projections and more below.

Panthers at 49ers Odds, Picks & Predictions

  • Odds: 49ers -5.5
  • Over/Under: 42
  • Kickoff: 4:05 p.m. ET
  • TV Channel: FOX

Odds as of Sunday morning and via PointsBet, where Action Network users can access an exclusive promotion to get a 200% deposit match (deposit $50, bet with $150).

Our analysts and experts break down the most important angles of this game.

Here’s an excerpt, but you can read the full story here.

The biggest mismatch on paper is the run game.

The Panthers rank 30th in Football Outsiders’ run defense DVOA, which is cause for concern against a 49ers rushing attack that ranks second with an average of 172.7 rushing yards per game. But if you look deeper, there are opportunities for the Panthers to have better success than past 49ers’ opponents.

See our full betting breakdown for Panthers-49ers.

Our Experts’ Favorite Week 8 Picks

Our staff breaks down how they’re betting every 1 and 4 p.m. ET game. See their picks.

Sean Koerner’s Projected Panthers-49ers Odds

Sean Koerner uses his NFL Power Ratings to project a spread and total for every game. See whether he thinks either are worth a bet in this matchup.

Pick ‘Em Confidence Rating

Sean Koerner ranks every straight-up and against-the-spread pick for pools in his Pick ‘Em Confidence Ratings. You can even create custom ATS ratings based on the specific spreads your league is using.

See where the Panthers and 49ers rank.

Survivor Pool Recommendations

Seven weeks down. Ten to go. Should you roll with Carolina or San Francisco in Week 8? Our NFL simulations reveal the best survivor pool picks.

Week 8 Fantasy Football Rankings

Our trio of experts are obsessively updating their fantasy football rankings so you can set your lineups with confidence. Here’s how they rank QBs, RBs, WRs, TEs and Flex players for PPR, standard and half PPR leagues.

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