Betting odds: Tampa Bay Buccaneers at New Orleans Saints
- Spread: Saints -10
- Over/Under: 49.5
- Time: 1 p.m. ET
- TV channel: FOX
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Trends to know: The Saints are Week 1’s biggest favorite. Since 1993, the biggest favorites on opening weekend of the NFL season have burned bettors, going 12-22 against the spread (35%). (More than one team closed with the same spread some years.)
All teams favored by more than a touchdown in Week 1 over that same span are 19-36 ATS (35%). — John Ewing
Did you know? Ryan Fitzpatrick made his first start in the NFL for the St. Louis Rams in 2005. He’s struggled as an underdog since then, going 28-41-5 ATS (-14.2 units), making him the least profitable QB as an underdog in the NFL. — Evan Abrams
Injury watch: The Bucs likely won’t have first-round defensive tackle Vita Vea (calf), but left tackle Donovan Smith (knee) at least has a chance to suit up after a worrisome initial diagnosis back in August.
Fitzpatrick will run the offense during Jameis Winston’s three-game suspension.
The Saints could be without starting guard Andrus Peat (quad) in addition to suspended running back Mark Ingram, but they’re largely healthy elsewhere on the roster. — Ian Hartitz
DFS edge: It’s not hyperbole to say Drew Brees and Michael Thomas are the most efficient QB-WR combo in the league.
They have connected on a ridiculous 72.6% of targets over the past two seasons — the highest rate over the past 25 years (minimum 150 targets).
Thomas has been particularly dominant against divisional rivals, averaging an additional 3.2 DraftKings points per game with a +5.1 Plus/Minus and 66% Consistency Rating in 12 games against the NFC South. — Hartitz
Editor’s note: The opinions on this game are from the individual writers and are based on their research, analysis and perspective. They are independent of, and may not always match with, the algorithm-driven Best Bets from Sports Insights.