NFL Odds, Picks & Predictions For 49ers vs. Rams: How Pros Are Betting This Spread & Total

NFL Odds, Picks & Predictions For 49ers vs. Rams: How Pros Are Betting This Spread & Total article feature image
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Photo by Chris Graythen/Getty Images. Pictured: Quarterback Nick Mullens of the San Francisco 49ers.

NFL Odds: 49ers vs. Rams

49ers Odds +6.5
Rams Odds -6.5
Over/Under 44.5
PRO Projections Rams -5.6 | O/U: 44.4
Time/Channel  4:05 p.m. ET, FOX
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Following Thursday’s two-game Thanksgiving slate, NFL Week 12 rolls on with 12.

At the time of writing our NFL PRO Report value indicators don’t see much on Sunday’s schedule as a whole, but do show 49ers vs. Rams as the matchup savvy bettors should be eyeing.

NFL Picks: 49ers vs. Rams Spread

Big Bets

The 49ers are attracting 49% of the spread bets in this matchup, but those tickets account for 66% of real money wagered (click here for live NFL betting percentages).

With sportsbooks clearly heavy with San Fran money, it’s easy to see why this line has been adjusted from +7 to +6.5.

PRO Systems

Historical betting data supports the road underdogs as well as the 49ers fit our Road Trips With Line Move PRO Betting System.

The crux of this system finds value with undervalued road teams, specifically with sharp line movement.

Teams in this spot are 102-61-2 (63%) against the spread since 2003.

Top Experts

Two of our NFL betting experts are coming along for the ride as well by backing the Niners and the points.

PRO Report Pick: 49ers +6.5

NFL Picks: 49ers vs. Rams Over/Under

Sharp Action

Sharp betting action isn’t always easy to pinpoint, but the 49ers vs. Rams over/under smacks you right in the face with it.

According to Sports Insights’ Bet Signals, wiseguys immediately steamed this under, leaving little doubt as to why the total has dropped from 47 to 44.5.

Steam refers to sudden, uniform line movement that is often the result of professionals making the same bet at multiple sportsbooks, all at once.

Big Money

As is typical, pros are backing up their bets with big bucks.

The 49ers vs. Rams under has landed 83% of the money wagered on the total, confirming that sportsbooks will certainly be rooting for a high-scoring game.

PRO Systems

And just like the spread, our PRO Betting Systems are taking a side on the total.

The Rams vs. 49ers under is a match for the Divisional Unders PRO System, which finds value by taking advantage of the familiarity between teams within the same division.

Unders fitting this system’s criteria are 197-122-4 (62%) this season.

Three additional Week 12 games match this historically-profitable angle, so be sure to take advantage of Black Friday promotion and track all PRO Betting System picks at a 50% discount.

PRO Report Pick: Under 44.5

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