| Cardinals | Devon Kennard | OLB | Out | Hamstring | Devon Kennard (Hamstring) is out this week. | Sep 18 |
| Cardinals | Antoine Wesley | WR | Out | COVID-19 List | Antoine Wesley (COVID Protocols) is out this week. | Sep 10 |
| Cardinals | Eno Benjamin | RB | Out | Undisclosed | Eno Benjamin (Undisclosed) is out this week. | Sep 12 |
| Falcons | Frank Darby | WR | Out | Calf | Frank Darby (Calf) is out this week. | Sep 16 |
| Ravens | Jimmy Smith | CB | Out | Ankle | Jimmy Smith (Ankle) is out this week. | Sep 13 |
| Ravens | L.J. Fort | LB | Out | Knee | L.J. Fort (Knee) is out this week. | Sep 14 |
| Ravens | Derek Wolfe | DE | Out | Back | Derek Wolfe (Back) is out this week. | Sep 12 |
| Ravens | Marcus Peters | CB | Out for season | Knee | Marcus Peters (Knee) is out for the season. | Sep 12 |
| Ravens | Nick Boyle | TE | Out indefinitely | Knee | Nick Boyle (Knee) is injured this week. | Sep 10 |
| Ravens | Ronnie Stanley | OT | Out | Undisclosed | Ronnie Stanley (Undisclosed) is out this week. | Sep 19 |
| Ravens | Gus Edwards | RB | Out for season | Knee | Gus Edwards (Knee) is out for the season. | Sep 12 |
| Ravens | Chris Westry | CB | Out | Knee | Chris Westry (Knee) is out this week. | Sep 16 |
| Ravens | Miles Boykin | WR | Out | Hamstring | Miles Boykin (Hamstring) is out this week. | Sep 14 |
| Ravens | J.K. Dobbins | RB | Out for season | Knee | JK Dobbins (Knee) is out for the season. | Sep 12 |
| Ravens | Tyre Phillips | G | Out | Knee | Tyre Phillips (Knee) is out this week. | Sep 14 |
| Ravens | Daelin Hayes | OLB | Out | Knee | Daelin Hayes (Knee) is out this week. | Sep 13 |
| Panthers | Shi Smith | WR | Out | Undisclosed | Shi Smith (Undisclosed) is out this week. | Sep 19 |
| Bears | Andy Dalton | QB | Questionable | Knee | Andy Dalton (Knee) is questionable this week. | Sep 19 |
| Bears | Eddie Goldman | DT | Out | Knee | Eddie Goldman (Knee) is out this week. | Sep 19 |
| Bengals | Trae Waynes | CB | Out | Hamstring | Trae Waynes (Hamstring) is out this week. | Sep 12 |
| Bengals | Ricardo Allen | SAF | Out | Hand | Ricardo Allen (Hand) is out this week. | Sep 15 |
| Browns | Chris Hubbard | OT | Out | Triceps | Chris Hubbard (Triceps) is out this week. | Sep 17 |
| Browns | Odell Beckham Jr. | WR | Out | Undisclosed | Odell Beckham (Undisclosed) is out this week. | Sep 12 |
| Browns | Anthony Walker | LB | Out | Hamstring | Anthony Walker (Hamstring) is out this week. | Sep 17 |
| Browns | Ronnie Harrison Jr. | SAF | Questionable | Ankle | Ronnie Harrison (Ankle) is questionable this week. | Sep 12 |
| Cowboys | DeMarcus Lawrence | DE | Out | Foot | Lawrence is out with foot | Sep 16 |
| Cowboys | Ty Nsekhe | T | Out | Illness | Ty Nsekhe (Illness) is out this week. | Sep 18 |
| Cowboys | Michael Gallup | WR | Out | Calf | Michael Gallup (Calf) is out this week. | Sep 15 |
| Broncos | Mike Boone | RB | Out | Quad | Mike Boone (Quad) is out this week. | Sep 10 |
| Broncos | Michael Ojemudia | CB | Out | Hamstring | Michael Ojemudia (Hamstring) is out this week. | Sep 14 |
| Lions | Tyrell Williams | WR | Out | Undisclosed | Tyrell Williams (Undisclosed) is out this week. | Sep 20 |
| Lions | Taylor Decker | OT | Out | Finger | Taylor Decker (Finger) is out this week. | Sep 12 |
| Lions | Jeff Okudah | CB | Out for season | Achilles | Jeffrey Okudah (Achilles) is out for the season. | Sep 14 |
| Lions | Jermar Jefferson | RB | Out | Undisclosed | Jermar Jefferson (Undisclosed) is out this week. | Sep 20 |
| Packers | Za'Darius Smith | LB | Out | Back | Za'Darius Smith (Back) is out this week. | Sep 17 |
| Texans | Tyrod Taylor | QB | Out | Hamstring | Tyrod Taylor (Hamstring) is out this week. | Sep 19 |
| Texans | Kevin Pierre-Louis | LB | Questionable | Thigh | Kevin Pierre-Louis (Thigh) is questionable this week. | Sep 12 |
| Texans | Deshaun Watson | QB | Out | Undisclosed | Deshaun Watson (Undisclosed) is out this week. | Sep 10 |
| Texans | Anthony Miller | WR | Out | Shoulder | Anthony Miller (Shoulder) is out this week. | Sep 19 |
| Colts | Xavier Rhodes | CB | Out | Calf | Xavier Rhodes (Calf) is out this week. | Sep 17 |
| Colts | Carson Wentz | QB | Questionable | Ankle | Carson Wentz (Ankle) is questionable this week. | Sep 19 |
| Colts | Braden Smith | OL | Out | Foot | Braden Smith (Foot) is out this week. | Sep 18 |
| Colts | Parris Campbell | WR | Out | Abdomen | Parris Campbell (Abdomen) is out this week. | Sep 19 |
| Jaguars | Lerentee McCray | DE | Out | Hamstring | Lerentee McCray (Hamstring) is out this week. | Sep 19 |
| Jaguars | Tre Herndon | CB | Out | Knee | Willie Herndon (Knee) is out this week. | Sep 12 |
| Jaguars | Jordan Smith | DE | Out | Knee | Jordan Smith (Knee) is out this week. | Sep 19 |
| Raiders | Richie Incognito | G | Out | Calf | Richie Incognito (Calf) is out this week. | Sep 12 |
| Raiders | Denzelle Good | G | Out for season | Knee | Denzelle Good (Knee) is out for the season. | Sep 14 |
| Raiders | Marcus Mariota | QB | Questionable | Quad | Marcus Mariota (Quad) is questionable this week. | Sep 15 |
| Raiders | Nick Kwiatkoski | LB | Out | Concussion | Nick Kwiatkoski (Concussion) is out this week. | Sep 18 |
| Raiders | Clelin Ferrell | DE | Out | Back | Clelin Ferrell (Back) is out this week. | Sep 13 |
| Raiders | Roderic Teamer | SAF | Out | Shoulder | Roderic Teamer (Shoulder) is out this week. | Sep 13 |
| Raiders | Josh Jacobs | RB | Out | Lower Body | Josh Jacobs (Lower Body) is out this week. | Sep 17 |
| Chargers | Chris Harris Jr. | CB | Out | Shoulder | Chris Harris (Shoulder) is out this week. | Sep 17 |
| Chargers | Bryan Bulaga | T | Out | Groin, Back | Bryan Bulaga (Groin, Back) is out this week. | Sep 18 |
| Chargers | Joshua Kelley | RB | Out | Undisclosed | Josh Kelley (Undisclosed) is out this week. | Sep 12 |
| Chargers | Tre' McKitty | TE | Out | Undisclosed | Tre' McKitty (Undisclosed) is out this week. | Sep 12 |
| Rams | Jonah Williams | DE | Questionable | Stinger | Jonah Williams (Stinger) is questionable this week. | Nov 13 |
| Dolphins | Tua Tagovailoa | QB | Questionable | Ribs | Tua Tagovailoa (Ribs) is questionable this week. | Sep 19 |
| Dolphins | Austin Jackson | OT | Questionable | Illness | Austin Jackson (Illness) is questionable this week. | Sep 12 |
| Dolphins | Raekwon Davis | DT | Out | Knee | Raekwon Davis (Knee) is out this week. | Sep 14 |
| Vikings | Anthony Barr | LB | Out | Knee | Anthony Barr (Knee) is out this week. | Sep 12 |
| Vikings | Harrison Hand | CB | Out | Hamstring | Harrison Hand (Hamstring) is out this week. | Sep 18 |
| Patriots | Trent Brown | OL | Out | Calf | Trenton Brown (Calf) is out this week. | Sep 19 |
| Patriots | Malcolm Perry | WR | Out | Foot | Malcolm Perry (Foot) is out this week. | Sep 12 |
| Patriots | Ronnie Perkins | LB | Out | Shoulder | Ronnie Perkins (Shoulder) is out this week. | Sep 19 |
| Patriots | Rhamondre Stevenson | RB | Out | Undisclosed | Rhamondre Stevenson (Undisclosed) is out this week. | Sep 19 |
| Patriots | Quinn Nordin | K | Out | Abdominal | Quinn Nordin (Abdominal) is out this week. | Sep 18 |
| Saints | Ken Crawley | CB | Out | Hamstring | Ken Crawley (Hamstring) is out this week. | Sep 12 |
| Saints | Marshon Lattimore | CB | Out | Hand | Marshon Lattimore (Hand) is out this week. | Sep 19 |
| Saints | Marcus Davenport | DE | Out | Shoulder | Marcus Davenport (Shoulder) is out this week. | Sep 19 |
| Saints | Tre'Quan Smith | WR | Out | Hamstring | Tre'Quan Smith (Hamstring) is out this week. | Sep 12 |
| Saints | C.J. Gardner-Johnson | SAF | Out | Knee | Chauncey Gardner-Johnson (Knee) is out this week. | Sep 19 |
| Saints | Erik McCoy | OL | Out | Calf | Erik McCoy (Calf) is out this week. | Sep 14 |
| Giants | Evan Engram | TE | Out | Calf | Evan Engram (Calf) is out this week. | Sep 10 |
| Giants | Nick Gates | C | Out for season | Leg | Nick Gates (Leg) is out for the season. | Sep 17 |
| Giants | Shane Lemieux | OL | Out | Knee | Shane Lemieux (Knee) is out this week. | Sep 15 |
| Jets | Jamison Crowder | WR | Out | Groin | Jamison Crowder (Groin) is out this week. | Sep 19 |
| Jets | Lamarcus Joyner | SAF | Out for season | Triceps | Lamarcus Joyner (Triceps) is out for the season. | Sep 15 |
| Jets | Blake Cashman | LB | Out | Hamstring | Blake Cashman (Hamstring) is out this week. | Sep 15 |
| Jets | La'Mical Perine | RB | Out | Undisclosed | La'Mical Perine (Undisclosed) is out this week. | Sep 19 |
| Jets | Braden Mann | P | Out | Knee | Braden Mann (Knee) is out this week. | Sep 15 |
| Jets | Jamien Sherwood | LB | Out | Ankle | Jamien Sherwood (Ankle) is out this week. | Sep 19 |
| Eagles | Brandon Brooks | G | Out | Chest | Brandon Brooks (Chest) is out this week. | Sep 19 |
| Eagles | Brandon Graham | DE | Out for season | Achilles | Brandon Graham (Achilles) is out for the season. | Sep 19 |
| Eagles | Gardner Minshew | QB | Out | Thumb | Gardner Minshew (Thumb) is out this week. | Sep 12 |
| Steelers | Joe Haden | CB | Out | Groin | Joe Haden (Groin) is out this week. | Sep 19 |
| Steelers | Devin Bush Jr. | LB | Out | Groin | Devin Bush (Groin) is out this week. | Sep 19 |
| Steelers | Benny Snell Jr. | RB | Doubtful | Knee | Snell is doubtful with knee | Oct 31 |
| Steelers | Carlos Davis | DT | Out | Knee | Carlos Davis (Knee) is out this week. | Sep 18 |
| 49ers | Raheem Mostert | RB | Out for season | Knee | Raheem Mostert (Knee) is out for the season. | Sep 14 |
| 49ers | Jason Verrett | CB | Out for season | Knee | Jason Verrett (Knee) is out for the season. | Sep 16 |
| 49ers | Emmanuel Moseley | CB | Out | Knee | Emmanuel Moseley (Knee) is out this week. | Sep 19 |
| 49ers | Jalen Hurd | WR | Out | Knee | Jalen Hurd (Knee) is out this week. | Sep 12 |
| 49ers | JaMycal Hasty | RB | Out | Ankle | JaMycal Hasty (Ankle) is out this week. | Sep 20 |
| Seahawks | Rashaad Penny | RB | Out | Calf | Rashaad Penny (Calf) is out this week. | Sep 19 |
| Seahawks | D'Wayne Eskridge | WR | Out | Undisclosed | D'Wayne Eskridge (Undisclosed) is out this week. | Sep 19 |
| Buccaneers | Sean Murphy-Bunting | CB | Out | Elbow | Sean Murphy-Bunting (Elbow) is out this week. | Sep 14 |
| Titans | Taylor Lewan | OT | Out | Leg | Taylor Lewan (Leg) is out this week. | Sep 19 |
| Titans | Sam Ficken | K | Out | Groin | Sam Ficken (Groin) is out this week. | Sep 12 |
| Titans | Anthony Firkser | TE | Questionable | Knee | Anthony Firkser (Knee) is questionable this week. | Sep 18 |
| Titans | Amani Hooker | DB | Out | Foot | Amani Hooker (Foot) is out this week. | Sep 15 |
| Football Team | Ryan Fitzpatrick | QB | Out | Hip | Ryan Fitzpatrick (Hip) is out this week. | Sep 14 |
| Football Team | Curtis Samuel | WR | Out | Groin | Curtis Samuel (Groin) is out this week. | Sep 12 |