 Cardinals | Jordan Phillips | DT | Questionable | Ankle | Jordan Phillips (Ankle) is questionable this week. | Sep 5 |
| Cardinals | Dre Kirkpatrick | CB | Questionable | Neck | Dre Kirkpatrick (Neck) is questionable this week. | Sep 5 |
| Cardinals | Maxx Williams | TE | Out | Placed on IR. | Maxx Williams (Ankle) is out this week. | Sep 1 |
| Cardinals | Mason Cole | C | Out | Hand | Mason Cole (Hand) is Out this week. | Sep 5 |
| Cardinals | Jalen Thompson | FS | Out | Placed on IR. | Jalen Thompson (Ankle) is Out this week. | Sep 4 |
| Cardinals | Josh Jones | T | Questionable | Ankle | Josh Jones (Ankle) is Questionable this week. | Sep 5 |
 Falcons | Ricardo Allen | CB | Out | Elbow | Ricardo Allen (Elbow) is out this week. | Sep 5 |
| Falcons | Darqueze Dennard | CB | Out | Placed on IR. | Darqueze Dennard (Undisclosed) is out this week. | Sep 2 |
| Falcons | Dante Fowler Jr. | DE | Questionable | Ankle | Dante Fowler (Ankle) is questionable this week. | Sep 5 |
| Falcons | Charles Harris | OLB | Out | Ankle | Charles Harris (Ankle) is Out this week. | Sep 5 |
| Falcons | Takkarist McKinley | DE | Questionable | Groin | Takk McKinley (Groin) is questionable this week. | Sep 5 |
| Falcons | Foyesade Oluokun | MLB | Questionable | Hamstring | Foyesade Oluokun (Hamstring) is questionable this week. | Sep 5 |
| Falcons | Kaleb McGary | T | Questionable | Knee | Kaleb McGary (Knee) is questionable this week. | Sep 5 |
| Falcons | Kendall Sheffield | CB | Out | Foot | Kendall Sheffield (Foot) is Out this week. | Sep 5 |
| Falcons | A.J. Terrell | CB | Out | Illness | A.J. Terrell (Illness) is out this week. | Sep 6 |
 Ravens | Jimmy Smith | CB | Questionable | Hip | Jimmy Smith (Hip) is Questionable this week. | Sep 5 |
| Ravens | DeAndrew White | WR | Out for season | Placed on IR. | White is out for season with undisclosed | Sep 4 |
| Ravens | Tavon Young | CB | Out for season | Knee | Tavon Young (Knee) is out for the season. | Sep 1 |
| Ravens | Ronnie Stanley | T | Questionable | Hip | Ronnie Stanley (Hip) is Questionable this week. | Sep 5 |
| Ravens | Justin Madubuike | DT | Out | Knee | Justin Madubuike (Knee) is Out this week. | Sep 5 |
 Bills | Matt Milano | OLB | Questionable | Hamstring | Matt Milano (Hamstring) is questionable this week. | Sep 5 |
| Bills | Taron Johnson | CB | Questionable | Groin | Taron Johnson (Groin) is questionable this week. | Sep 5 |
| Bills | Tremaine Edmunds | MLB | Out | Shoulder | Fe'Zahn Edmunds (Shoulder) is Out this week. | Sep 5 |
| Bills | Del'Shawn Phillips | OLB | Out | Quad | Del'Shawn Phillips (Quad) is Out this week. | Sep 5 |
| Bills | Dawson Knox | TE | Out | Concussion | Dawson Knox (Concussion) is out this week. | Sep 5 |
| Bills | Isaiah Hodgins | WR | Out | Shoulder | Isaiah Hodgins (Shoulder) is Out this week. | Sep 1 |
 Panthers | Kawann Short | DT | Doubtful | Foot | Kawann Short (Foot) is doubtful this week. | Sep 5 |
| Panthers | Christian McCaffrey | RB | Out | Ankle | Christian McCaffrey (Ankle) is out this week. | Sep 2 |
| Panthers | Keith Kirkwood | WR | Out | Placed on IR | Keith Kirkwood (Shoulder) is Out this week. | Sep 1 |
| Panthers | Dennis Daley | G | Doubtful | Ankle | Dennis Daley (Ankle) is doubtful this week. | Sep 5 |
| Panthers | Omar Bayless | WR | Out for season | Placed on IR. | Bayless is out for season with knee | Sep 4 |
 Bears | Khalil Mack | OLB | Questionable | Knee | Khalil Mack (Knee) is Questionable this week. | Sep 5 |
| Bears | Mario Edwards Jr. | DT | Questionable | Glute | Mario Edwards (Glute) is questionable this week. | Sep 5 |
| Bears | Tarik Cohen | RB | Out | Placed on IR. | Tarik Cohen (Knee) is out this week. | Sep 1 |
| Bears | Darion Clark | TE | Out | Placed on IR. | Darion Clark (Undisclosed) is out this week. | Sep 2 |
 Bengals | C.J. Uzomah | TE | Out for season | Achilles | CJ Uzomah (Achilles) is Out for Season this week. | Sep 5 |
| Bengals | Geno Atkins | DT | Out | Shoulder | Geno Atkins (Shoulder) is Out this week. | Sep 3 |
| Bengals | A.J. Green | WR | Out for season | Ankle | Green is out for season with ankle | Dec 1 |
| Bengals | Shawn Williams | SS | Questionable | Calf | Shawn Williams (Calf) is questionable this week. | Sep 5 |
| Bengals | Mike Daniels | DT | Questionable | Groin | Mike Daniels (Groin) is questionable this week. | Sep 5 |
| Bengals | Jonah Williams | T | Out | Shoulder | Williams is out with shoulder | Sep 3 |
| Bengals | Austin Seibert | K | Out | Undisclosed | Austin Seibert (Undisclosed) is Out this week. | Sep 4 |
 Browns | Olivier Vernon | DE | Out | Abdomen | Olivier Vernon (Abdomen) is out this week. | Sep 5 |
| Browns | Adrian Clayborn | DE | Questionable | Hip | Adrian Clayborn (Hip) is questionable this week. | Sep 5 |
| Browns | Rashard Higgins | WR | Out | Undisclosed | Rashard Higgins (Undisclosed) is out this week. | Sep 0 |
| Browns | JoJo Natson | WR | Out | Placed on IR. | Jojo Natson (Knee) is out this week. | Sep 1 |
| Browns | David Njoku | TE | Out | Placed on IR. | David Njoku (Knee) is Out this week. | Sep 1 |
| Browns | Denzel Ward | CB | Questionable | Groin | Denzel Ward (Groin) is questionable this week. | Sep 5 |
| Browns | Mack Wilson | OLB | Questionable | Knee | Mack Wilson (Knee) is questionable this week. | Sep 5 |
| Browns | Greedy Williams | CB | Out | Shoulder | Greedy Williams (Shoulder) is Out this week. | Sep 3 |
| Browns | Jacob Phillips | OLB | Out | Knee | Jacob Phillips (Knee) is Out this week. | Sep 3 |
 Cowboys | Demarcus Lawrence | DE | Questionable | Knee | Demarcus Lawrence (Knee) is questionable this week. | Sep 5 |
| Cowboys | Sean Lee | OLB | Out | Hernia | Sean Lee (Hernia) is Out this week. | Sep 3 |
| Cowboys | Tyron Smith | T | Questionable | Neck | Tyron Smith (Neck) is questionable this week. | Sep 5 |
| Cowboys | Chidobe Awuzie | CB | Out | Hamstring | Chidobe Awuzie (Hamstring) is out this week. | Sep 5 |
| Cowboys | Blake Jarwin | TE | Out | Placed on IR. | Blake Jarwin (Knee) is Out this week. | Sep 2 |
| Cowboys | Ventell Bryant | WR | Out | Placed on IR. | Ventell Bryant (Knee) is out this week. | Sep 2 |
 Broncos | Jurrell Casey | DT | Out | Placed on IR. | Jurrell Casey (Biceps) is out this week. | Sep 1 |
| Broncos | Von Miller | OLB | Out | Knee | Von Miller (Knee) is Out this week. | Sep 0 |
| Broncos | A.J. Bouye | CB | Out | Placed on IR. | A.J. Bouye (Shoulder) is Out this week. | Sep 5 |
| Broncos | Mark Barron | ILB | Out | Hamstring | Mark Barron (Hamstring) is Out this week. | Sep 5 |
| Broncos | Austin Calitro | ILB | Out | Placed on IR. | Austin Calitro (Hamstring) is out this week. | Sep 1 |
| Broncos | Elijah Wilkinson | T | Out | Placed on IR. | Elijah Wilkinson (Leg) is out this week. | Sep 2 |
| Broncos | Courtland Sutton | WR | Out | Placed on IR. | Courtland Sutton (Knee) is out this week. | Sep 2 |
| Broncos | Davontae Harris | CB | Out | Hamstring | Davontae Harris (Hamstring) is out this week. | Sep 5 |
| Broncos | Dre'Mont Jones | DT | Out | Placed on IR. | Dre'Mont Jones (Undisclosed) is out this week. | Sep 2 |
 Lions | Justin Coleman | CB | Out | Placed on IR. | Justin Coleman (Undisclosed) is Out this week. | Sep 2 |
| Lions | Desmond Trufant | CB | Doubtful | Hamstring | Desmond Trufant (Hamstring) is doubtful this week. | Sep 5 |
| Lions | Darryl Roberts | CB | Questionable | Groin | Darryl Roberts (Groin) is Questionable this week. | Sep 5 |
| Lions | Halapoulivaati Vaitai | T | Questionable | Foot | Halapoulivaati Vaitai (Foot) is Questionable this week. | Sep 5 |
| Lions | Joe Dahl | G | Out | Groin | Joe Dahl (Groin) is Out this week. | Sep 5 |
| Lions | Bo Scarbrough | RB | Out | Placed on IR with undisclosed injury. | Bo Scarbrough (Undisclosed) is Out this week. | Sep 1 |
| Lions | C.J. Moore | FS | Questionable | Hamstring | C.J. Moore (Hamstring) is Questionable this week. | Sep 5 |
 Packers | Lane Taylor | G | Out | Knee | Lane Taylor (Knee) is Out this week. | Sep 5 |
| Packers | Kenny Clark | NT | Questionable | Groin | Kenny Clark (Groin) is questionable this week. | Sep 5 |
| Packers | Equanimeous St. Brown | WR | Out | Knee | Equanimeous St Brown (Knee) is Out this week. | Sep 5 |
| Packers | Raven Greene | FS | Questionable | Quad | Raven Greene (Quad) is Questionable this week. | Sep 5 |
| Packers | Randy Ramsey | OLB | Doubtful | Groin | Randy Ramsey (Groin) is doubtful this week. | Sep 5 |
| Packers | Elgton Jenkins | G | Questionable | Back | Elgton Jenkins (Back) is questionable this week. | Sep 5 |
| Packers | Lucas Patrick | G | Questionable | Shoulder | Lucas Patrick (Shoulder) is Questionable this week. | Sep 5 |
| Packers | Josiah Deguara | TE | Out | Shin | Josiah Deguara (Shin) is out this week. | Sep 0 |
| Packers | Patrick Taylor Jr. | RB | Out | Placed on IR. | Patrick Taylor (Undisclosed) is out this week. | Sep 2 |
 Texans | Peter Kalambayi | ILB | Questionable | Hamstring | Peter Kalambayi (Hamstring) is Questionable this week. | Sep 5 |
| Texans | Cullen Gillaspia | RB | Out | Inactive for Week 1. | Cullen Gillaspia (Hamstring) is Out this week. | Sep 4 |
| Texans | Kahale Warring | TE | Out | Placed on IR. | Kahale Warring (Undisclosed) is Out this week. | Sep 3 |
| Texans | Isaiah Coulter | WR | Out | Placed on IR with undisclosed injury. | Isaiah Coulter (Undisclosed) is Out this week. | Sep 1 |
 Colts | Marlon Mack | RB | Out | Placed on IR. | Marlon Mack (Achilles) is Out this week. | Sep 3 |
| Colts | Malik Hooker | FS | Out for season | Achilles | Malik Hooker (Achilles) is Out for Season this week. | Sep 1 |
| Colts | Parris Campbell | WR | Out | Knee | Parris Campbell (Knee) is out this week. | Sep 2 |
| Colts | Bruce Anderson III | RB | Out | Undisclosed | Bruce Anderson (Undisclosed) is Out this week. | Sep 1 |
 Jaguars | Josh Lambo | K | Out | Placed on IR. | Josh Lambo (Hip) is out this week. | Sep 3 |
| Jaguars | Brandon Linder | G | Out | Knee | Brandon Linder (Knee) is out this week. | Sep 3 |
| Jaguars | Devine Ozigbo | RB | Out | Placed on IR. | Devine Ozigbo (Hamstring) is Out this week. | Sep 4 |
| Jaguars | Ryquell Armstead | RB | Out | Placed on Reserve/COVID-19 list | Ryquell Armstead (Illness) is Out this week. | Sep 1 |
 Chiefs | Dorian O'Daniel | ILB | Questionable | Ankle | Dorian O'Daniel (Ankle) is questionable this week. | Sep 6 |
| Chiefs | Charvarius Ward | CB | Questionable | Hand | Charvarius Ward (Hand) is questionable this week. | Sep 6 |
 Raiders | Richie Incognito | G | Out | Placed on IR. | Richie Incognito (Achilles) is out this week. | Sep 3 |
| Raiders | Sam Young | T | Questionable | Groin | Sam Young (Groin) is questionable this week. | Sep 5 |
| Raiders | Marcus Mariota | QB | Out | Placed on IR with pectoral strain. | Marcus Mariota (Chest) is Out this week. | Sep 1 |
| Raiders | Tyrell Williams | WR | Out for season | Torn Labrum | Williams is out for season with shoulder | Sep 4 |
| Raiders | Trent Brown | T | Out | Calf | Trenton Brown (Calf) is out this week. | Sep 5 |
| Raiders | Nick Kwiatkoski | ILB | Out | Pectoral | Nick Kwiatkoski (Pectoral) is out this week. | Sep 5 |
 Chargers | Tyrod Taylor | QB | Out | Chest | Tyrod Taylor (Chest) is out this week. | Sep 5 |
| Chargers | Mike Pouncey | C | Out for season | Placed on IR. | Mike Pouncey (Hip) is Out for Season this week. | Sep 4 |
| Chargers | Chris Harris Jr. | CB | Out | Placed on IR. | Chris Harris (Foot) is out this week. | Sep 2 |
| Chargers | Melvin Ingram | DE | Out | Placed on IR. | Melvin Ingram (Knee) is out this week. | Sep 6 |
| Chargers | Bryan Bulaga | T | Questionable | Knee | Bryan Bulaga (Knee) is questionable this week. | Sep 5 |
| Chargers | Trai Turner | G | Questionable | Groin | Trai Turner (Groin) is questionable this week. | Sep 5 |
| Chargers | Nick Vigil | OLB | Doubtful | Groin | Nick Vigil (Groin) is doubtful this week. | Sep 5 |
| Chargers | Rayshawn Jenkins | SS | Questionable | Groin | Rayshawn Jenkins (Groin) is questionable this week. | Sep 5 |
| Chargers | Justin Jones | DT | Out | Shoulder | Justin Jones (Shoulder) is out this week. | Sep 5 |
| Chargers | Asmar Bilal | LB | Out | Calf | Asmar Bilal (Calf) is out this week. | Sep 5 |
 Rams | Jamil Demby | G | Questionable | Hand | Jamil Demby (Hand) is Questionable this week. | Sep 5 |
| Rams | Darious Williams | CB | Questionable | Ankle | Darious Williams (Ankle) is questionable this week. | Sep 5 |
 Dolphins | Byron Jones | CB | Out | Achilles | Byron Jones (Achilles) is out this week. | Sep 3 |
| Dolphins | Clayton Fejedelem | SS | Doubtful | Pectoral | Clayton Fejedelem (Pectoral) is Doubtful this week. | Sep 5 |
 Vikings | Anthony Barr | OLB | Out | Placed on IR. | Anthony Barr (Pectoral) is out this week. | Sep 1 |
| Vikings | Danielle Hunter | DE | Out | Placed on IR. | Danielle Hunter (Neck) is Out this week. | Sep 3 |
| Vikings | Pat Elflein | G | Out | Placed on IR. | Pat Elflein (Undisclosed) is Out this week. | Sep 4 |
| Vikings | Mike Hughes | CB | Out | Neck | Mike Hughes (Neck) is out this week. | Sep 5 |
| Vikings | Kris Boyd | CB | Questionable | Hamstring | Kris Boyd (Hamstring) is questionable this week. | Sep 5 |
| Vikings | Cameron Dantzler | CB | Out | Ribs | Cameron Dantzler (Ribs) is Out this week. | Sep 5 |
| Vikings | Troy Dye | ILB | Out | Placed on IR. | Troy Dye (Foot) is out this week. | Sep 4 |
 Patriots | David Andrews | C | Out | Hand | David Andrews (Hand) is out this week. | Sep 5 |
| Patriots | Quincy Adeboyejo | WR | Out | Undisclosed | Quincy Adeboyejo (Undisclosed) is Out this week. | Sep 2 |
| Patriots | Adam Butler | DT | Questionable | Shoulder | Adam Butler (Shoulder) is Questionable this week. | Sep 5 |
| Patriots | Isaiah Wynn | T | Questionable | Calf | Isaiah Wynn (Calf) is questionable this week. | Sep 5 |
| Patriots | Gunner Olszewski | WR | Out | Foot | Gunner Olszewski (Foot) is Out this week. | Sep 5 |
| Patriots | Yodny Cajuste | T | Out | Placed on IR. | Yodny Cajuste (Knee) is Out this week. | Sep 4 |
| Patriots | Damien Harris | RB | Out | Placed on IR with hand injury. | Damien Harris (Hand) is Out this week. | Sep 1 |
| Patriots | Kyle Dugger | FS | Questionable | Ankle | Kyle Dugger (Ankle) is questionable this week. | Sep 5 |
| Patriots | Josh Uche | OLB | Doubtful | Foot | Josh Uche (Foot) is doubtful this week. | Sep 5 |
 Saints | Ty Montgomery | RB | Out | Placed on IR. | Ty Montgomery (Hamstring) is out this week. | Sep 2 |
| Saints | David Onyemata | DT | Questionable | Calf | David Onyemata (Calf) is questionable this week. | Sep 5 |
| Saints | Trey Hendrickson | DE | Questionable | Groin | Trey Hendrickson (Groin) is questionable this week. | Sep 5 |
| Saints | Marcus Davenport | DE | Questionable | Elbow | Marcus Davenport (Elbow) is questionable this week. | Sep 5 |
| Saints | Chase Hansen | OLB | Out | Hip | Chase Hansen (Hip) is Out this week. | Sep 0 |
 Giants | Cody Core | WR | Out | Placed on IR. | Cody Core (Achilles) is out this week. | Sep 2 |
| Giants | Sterling Shepard | WR | Out | Placed on IR. | Sterling Shepard (Toe) is out this week. | Sep 3 |
| Giants | Saquon Barkley | RB | Out | Knee | Saquon Barkley (Knee) is out this week. | Sep 2 |
| Giants | David Sills V | WR | Out | Placed on IR. | David Sills (Foot) is out this week. | Sep 2 |
| Giants | Tae Crowder | ILB | Questionable | Hamstring | Tae Crowder (Hamstring) is Questionable this week. | Sep 0 |
| Giants | Carter Coughlin | OLB | Questionable | Hamstring | Carter Coughlin (Hamstring) is Questionable this week. | Sep 5 |
 Jets | Le'Veon Bell | RB | Out | Placed on IR. | Le'Veon Bell (Hamstring) is Out this week. | Sep 2 |
| Jets | Connor McGovern | C | Questionable | Hamstring | Connor McGovern (Hamstring) is questionable this week. | Sep 5 |
| Jets | George Fant | T | Out | Concussion | George Fant (Concussion) is out this week. | Sep 5 |
| Jets | Nate Hairston | CB | Questionable | Hip | Nate Hairston (Hip) is questionable this week. | Sep 5 |
| Jets | Vyncint Smith | WR | Out | Placed on IR. | Vyncint Smith (Abdominal) is Out this week. | Sep 1 |
| Jets | Denzel Mims | WR | Out | Placed on IR. | Denzel Mims (Hamstring) is out this week. | Sep 2 |
| Jets | Ashtyn Davis | SS | Out | Groin | Ashtyn Davis (Groin) is out this week. | Sep 5 |
 Eagles | Joshua Perkins | TE | Out | Placed on IR. | Josh Perkins (Undisclosed) is out this week. | Sep 2 |
| Eagles | Dallas Goedert | TE | Out | Placed on IR. | Dallas Goedert (Ankle) is out this week. | Sep 2 |
| Eagles | Craig James | CB | Out | Thigh | Craig James (Thigh) is Out this week. | Sep 2 |
| Eagles | Jalen Reagor | WR | Out | Thumb | Jalen Reagor (Thumb) is out this week. | Sep 5 |
 Steelers | Benny Snell Jr. | RB | Doubtful | Knee | Snell is doubtful with knee | Oct 4 |
 49ers | Dee Ford | DE | Out | Neck | Dee Ford (Neck) is Out this week. | Sep 6 |
| 49ers | Jordan Reed | TE | Out | Placed on IR. | Jordan Reed (Knee) is out this week. | Sep 1 |
| 49ers | Tevin Coleman | RB | Out | Knee | Tevin Coleman (Knee) is out this week. | Sep 5 |
| 49ers | Tavon Austin | WR | Out | Placed on IR. | Tavon Austin (Knee) is Out this week. | Sep 1 |
| 49ers | Richard Sherman | CB | Out | Placed on IR. | Richard Sherman (Leg) is Out this week. | Sep 3 |
| 49ers | Ahkello Witherspoon | CB | Questionable | Hamstring | Ahkello Witherspoon (Hamstring) is questionable this week. | Sep 5 |
| 49ers | Richie James Jr. | WR | Out | Placed on IR. | Richard James (Hamstring) is out this week. | Sep 2 |
| 49ers | Dre Greenlaw | OLB | Out | Quad | Dre Greenlaw (Quad) is out this week. | Sep 5 |
| 49ers | Deebo Samuel | WR | Out | Foot | Deebo Samuel (Foot) is Out this week. | Sep 5 |
 Seahawks | Cedric Ogbuehi | T | Questionable | Pectoral | Cedric Ogbuehi (Pectoral) is questionable this week. | Sep 5 |
| Seahawks | Phillip Dorsett II | WR | Out | Placed on IR. | Phillip Dorsett (Foot) is out this week. | Sep 2 |
| Seahawks | Benson Mayowa | DE | Questionable | Groin | Benson Mayowa (Groin) is questionable this week. | Sep 5 |
| Seahawks | Neiko Thorpe | CB | Questionable | Hip | Neiko Thorpe (Hip) is questionable this week. | Sep 5 |
| Seahawks | Quinton Dunbar | CB | Questionable | Knee | Quinton Dunbar (Knee) is questionable this week. | Sep 5 |
| Seahawks | Rashaad Penny | RB | Out | Knee | Rashaad Penny (Knee) is out this week. | Sep 2 |
| Seahawks | Rasheem Green | DE | Out | Neck | Rasheem Green (Neck) is out this week. | Sep 5 |
 Buccaneers | Antony Auclair | TE | Out | Calf | Antony Auclair (Calf) is Out this week. | Sep 5 |
| Buccaneers | John Hurst | WR | Out | Placed on IR. | John Hurst (Ankle) is out this week. | Sep 2 |
 Titans | DaQuan Jones | NT | Out | Placed on Reserve/COVID-19 List. | DaQuan Jones (Illness) is out this week. | Sep 2 |
| Titans | Beau Brinkley | LS | Out | Placed on Reserve/COVID-19 List. | Beau Brinkley (Illness) is out this week. | Sep 2 |
| Titans | Senorise Perry | RB | Out | Placed on IR. | Senorise Perry (Undisclosed) is out this week. | Sep 2 |
| Titans | Adoree' Jackson | CB | Out | Knee | Adoree` Jackson (Knee) is Out this week. | Sep 0 |
| Titans | Derick Roberson | OLB | Out | Knee | Derick Roberson (Knee) is out this week. | Sep 5 |
| Titans | Chris Jackson | CB | Out | Hamstring | Chris Jackson (Hamstring) is out this week. | Sep 5 |
| Titans | Tommy Hudson | TE | Out | Placed on Reserve/COVID-19 List. | Tommy Hudson (Illness) is out this week. | Sep 2 |
 Football Team | Morgan Moses | T | Questionable | Hip | Morgan Moses (Hip) is questionable this week. | Sep 5 |
| Football Team | Cole Holcomb | ILB | Out | Knee | Cole Holcomb (Knee) is Out this week. | Sep 5 |
| Football Team | Saahdiq Charles | T | Out | Thigh | Saahdiq Charles (Thigh) is out this week. | Sep 5 |