 Cardinals | Marcus Gilbert | T | Out for season | Torn ACL | Gilbert is out for season with knee | Sep 2 |
| Cardinals | Robert Alford | CB | Out | Leg | Alford is out with leg | Sep 1 |
| Cardinals | D.J. Foster | RB | Out | Hamstring | Foster is out with hamstring | Oct 1 |
| Cardinals | Jonathan Bullard | DE | Out for season | Hamstring | Bullard is out for season with hamstring | Dec 4 |
| Cardinals | Zach Allen | DE | Out for season | Neck | Allen is out for season with neck | Nov 3 |
| Cardinals | Hakeem Butler | WR | Out for season | Finger | Butler is out for season with finger | Sep 1 |
 Falcons | James Carpenter | G | Out for season | Concussion | Carpenter is out for season with concussion | Dec 5 |
| Falcons | Steven Means | DE | Out for season | Achilles | Means is out for season with achilles | Sep 1 |
| Falcons | Keanu Neal | FS | Out for season | Achilles | Neal is out for season with achilles | Sep 1 |
| Falcons | Jamon Brown | G | Out | Illness | Brown is out with illness | Dec 5 |
| Falcons | Takkarist McKinley | DE | Out for season | Shoulder | McKinley is out for season with shoulder | Dec 3 |
| Falcons | Ito Smith | RB | Out | Neck | Smith is out with neck | Nov 5 |
| Falcons | Calvin Ridley | WR | Out for season | Abdomen | Ridley is out for season with abdomen | Dec 1 |
| Falcons | Kurt Benkert | QB | Out for season | Toe | Benkert is out for season with toe | Aug 2 |
| Falcons | Chris Lindstrom | G | Out | Foot | Lindstrom is out with foot | Sep 3 |
 Ravens | Derek Wolfe | DE | Out for season | Elbow | Wolfe is out for season with elbow | Dec 4 |
| Ravens | Justin Ellis | DT | Out for season | Knee | Ellis is out for season with knee | Sep 1 |
| Ravens | Pernell McPhee | OLB | Out | Triceps | McPhee is out with triceps | Oct 2 |
| Ravens | Tavon Young | CB | Out for season | Neck | Young is out for season with neck | Sep 1 |
 Bills | Josh Norman | CB | Out | Illness | Norman is out with illness | Dec 6 |
| Bills | Jason Croom | TE | Out | Hamstring | Croom is out with hamstring | Sep 1 |
| Bills | Harrison Phillips | DT | Out for season | Torn ACL | Phillips is out for season with knee | Nov 4 |
| Bills | Levi Wallace | CB | Out | Ankle | Wallace is out with ankle | Jan 6 |
| Bills | Robert Foster | WR | Out | None | Foster is out | Jan 6 |
| Bills | Mike Love | DE | Out | Pec | Love is out with pectoral | Sep 1 |
| Bills | Vosean Joseph | OLB | Out for season | Shoulder | Joseph is out for season with shoulder | Sep 1 |
| Bills | Tyrel Dodson | OLB | Suspended | Suspended | Dodson is suspended with suspension | Sep 3 |
 Panthers | Kawann Short | DE | Out for season | Shoulder | Short is out for season with shoulder | Oct 2 |
| Panthers | Shaq Thompson | OLB | Out | Ankle | Thompson is out with ankle | Dec 5 |
| Panthers | Graham Gano | K | Out for season | Knee | Gano is out for season with knee | Sep 1 |
| Panthers | Russell Okung | T | Out | Groin | Okung is out with groin | Dec 5 |
| Panthers | Eli Apple | CB | Out | Ankle | Apple is out with ankle | Jan 5 |
| Panthers | D.J. Moore | WR | Out | Concussion | Moore is out with concussion | Dec 5 |
| Panthers | Marquis Haynes | OLB | Out | Knee | Haynes is out with knee | Dec 0 |
| Panthers | Keith Kirkwood | WR | Out | Hamstring | Kirkwood is out with hamstring | Sep 2 |
| Panthers | Greg Little | T | Out for season | Ankle | Little is out for season with ankle | Dec 6 |
 Bears | Akiem Hicks | DT | Out | Elbow | Hicks is out with elbow | Dec 5 |
| Bears | Tashaun Gipson | FS | Out for season | Undisclosed | Gipson is out for season with undisclosed | Dec 2 |
| Bears | Danny Trevathan | ILB | Out for season | Elbow | Trevathan is out for season with elbow | Dec 3 |
| Bears | Bobby Massie | T | Out | Ankle | Massie is out with ankle | Dec 0 |
| Bears | Eddie Goldman | NT | Out | Concussion | Goldman is out with concussion | Dec 5 |
| Bears | Ben Braunecker | TE | Out for season | Concussion | Braunecker is out for season with concussion | Dec 6 |
| Bears | Jason Spriggs | T | Out for season | Abdomen | Spriggs is out for season with abdomen | Sep 1 |
| Bears | Rashaad Coward | T | Out | Knee | Coward is out with knee | Dec 0 |
| Bears | Adam Shaheen | TE | Out for season | Foot | Shaheen is out for season with foot | Dec 1 |
| Bears | Roquan Smith | ILB | Out for season | Pec | Smith is out for season with pectoral | Dec 2 |
 Bengals | A.J. Green | WR | Out for season | Ankle | Green is out for season with ankle | Dec 1 |
| Bengals | Xavier Su'a-Filo | G | Out for season | Leg | Su'a-Filo is out for season with leg | Dec 2 |
| Bengals | Alex Redmond | G | Out for season | Elbow | Redmond is out for season with elbow | Nov 5 |
| Bengals | Mackensie Alexander | CB | Out | Knee | Alexander is out with knee | Jan 4 |
| Bengals | William Jackson III | CB | Questionable | Shoulder | Jackson is questionable with shoulder | Dec 3 |
| Bengals | Brandon Wilson | FS | Out for season | Hand | Wilson is out for season with hand | Dec 5 |
| Bengals | Auden Tate | WR | Out for season | Leg | Tate is out for season with leg | Dec 4 |
| Bengals | Rodney Anderson | RB | Out for season | Torn ACL | Anderson is out for season with knee | Sep 1 |
| Bengals | Jonah Williams | T | Out | Shoulder | Williams is out with shoulder | Sep 3 |
 Browns | Kendall Lamm | T | Out | Knee | Lamm is out with knee | Dec 0 |
| Browns | Adrian Clayborn | DE | Out | Knee | Clayborn is out with knee | Dec 5 |
| Browns | Myles Garrett | DE | Suspended | Suspension | Garrett is suspended with suspension | Nov 5 |
| Browns | Daniel Ekuale | DT | Out | Calf | Ekuale is out with calf | Nov 5 |
| Browns | Drew Forbes | T | Out | Knee | Forbes is out with knee | Sep 1 |
 Cowboys | Dontari Poe | NT | Out for season | Quad | Poe is out for season with quad | Nov 3 |
| Cowboys | Tyron Smith | T | Out | Back | Smith is out with back | Dec 0 |
| Cowboys | Joe Thomas | ILB | Out | Knee | Thomas is out with knee | Dec 5 |
| Cowboys | Antwaun Woods | DT | Out | Hip/Knee | Woods is out with hip | Dec 0 |
| Cowboys | Noah Brown | WR | Out | Knee | Brown is out with knee | Sep 1 |
| Cowboys | Leighton Vander Esch | OLB | Out for season | Neck | Vander Esch is out for season with neck | Dec 3 |
 Broncos | Ja'Wuan James | T | Out | Knee | James is out with knee | Dec 5 |
| Broncos | A.J. Bouye | CB | Out | Wrist | Bouye is out with wrist | Dec 6 |
| Broncos | Kareem Jackson | CB | Suspended | Two games | Jackson is suspended with suspension | Dec 2 |
| Broncos | Bryce Callahan | CB | Out for season | Foot | Callahan is out for season with foot | Nov 5 |
| Broncos | Jeff Driskel | QB | Out for season | Hamstring | Driskel is out for season with hamstring | Dec 1 |
| Broncos | Jake Butt | TE | Out | Knee | Butt is out with knee | Sep 4 |
| Broncos | Elijah Wilkinson | T | Out | Ankle | Wilkinson is out with ankle | Dec 5 |
| Broncos | Bradley Chubb | OLB | Out for season | Torn ACL | Chubb is out for season with knee | Sep 1 |
| Broncos | Austin Fort | TE | Out for season | Knee | Fort is out for season with knee | Aug 5 |
 Lions | Marvin Jones Jr. | WR | Out for season | Ankle | Jones is out for season with ankle | Dec 2 |
| Lions | Kenny Wiggins | G | Out for season | Arm | Wiggins is out for season with arm | Dec 2 |
| Lions | Christian Jones | OLB | Out | Shoulder | Jones is out with shoulder | Dec 5 |
| Lions | Matthew Stafford | QB | Out for season | Back | Stafford is out for season with back | Dec 2 |
| Lions | Desmond Trufant | CB | Out for season | Arm | Trufant is out for season with arm | Dec 1 |
| Lions | Joe Dahl | G | Out for season | Back/Knee | Dahl is out for season with back | Dec 6 |
| Lions | Jayron Kearse | FS | Out | Toe/Knee | Kearse is out with toe | Jan 6 |
| Lions | Marvin Hall | WR | Out for season | Foot | Hall is out for season with foot | Nov 3 |
| Lions | Da'Shawn Hand | DE | Out for season | Ankle | Hand is out for season with ankle | Dec 4 |
| Lions | Jarrad Davis | MLB | Out for season | Ankle/Knee | Davis is out for season with ankle | Dec 6 |
| Lions | Chris Lacy | WR | Out | Leg | Lacy is out with leg | Sep 1 |
| Lions | Jahlani Tavai | MLB | Out for season | Shoulder | Tavai is out for season with shoulder | Dec 2 |
| Lions | T.J. Hockenson | TE | Out for season | Ankle | Hockenson is out for season with ankle | Dec 1 |
 Packers | Christian Kirksey | OLB | Out | Chest | Kirksey is out with chest | Sep 6 |
| Packers | Rick Wagner | T | Out | Knee | Wagner is out with knee | Dec 0 |
| Packers | Lane Taylor | G | Out | Biceps | Taylor is out with biceps | Sep 5 |
| Packers | Devin Funchess | WR | Out | Collarbone | Funchess is out with collarbone | Nov 5 |
| Packers | Equanimeous St. Brown | WR | Out for season | Ankle | St. Brown is out for season with ankle | Sep 1 |
| Packers | Raven Greene | FS | Out | Ankle | Greene is out with ankle | Sep 1 |
| Packers | Jace Sternberger | TE | Out | Ankle | Sternberger is out with ankle | Sep 4 |
 Texans | Senio Kelemete | G | Out | Wrist | Kelemete is out with wrist | Sep 3 |
| Texans | Jordan Akins | TE | Out | Hamstring | Akins is out with hamstring | Jan 6 |
| Texans | Tytus Howard | T | Out for season | Knee | Howard is out for season with knee | Dec 0 |
 Colts | Denico Autry | DT | Out | Concussion | Autry is out with concussion | Dec 0 |
| Colts | Trey Burton | TE | Out | Groin | Burton is out with groin | Nov 5 |
| Colts | Xavier Grimble | TE | Out | Calf | Grimble is out with calf | Sep 3 |
| Colts | Kenny Moore II | CB | Out | Ankle | Moore is out with ankle | Dec 0 |
| Colts | Kemoko Turay | DE | Out for season | Ankle | Turay is out for season with ankle | Oct 2 |
| Colts | Jordan Wilkins | RB | Out | Ankle | Wilkins is out with ankle | Dec 5 |
| Colts | Parris Campbell | WR | Out for season | Foot | Campbell is out for season with foot | Dec 2 |
| Colts | Khari Willis | SS | Out | Shoulder | Willis is out with shoulder | Dec 0 |
 Jaguars | Al Woods | DT | Suspended | Four games | Woods is suspended with suspension | Dec 5 |
| Jaguars | Lerentee McCray | DE | Out | Hamstring | McCray is out with hamstring | Nov 0 |
| Jaguars | Myles Jack | MLB | Out for season | Knee | Jack is out for season with knee | Dec 4 |
| Jaguars | James O'Shaughnessy | TE | Out for season | Torn ACL | O'Shaughnessy is out for season with knee | Oct 1 |
| Jaguars | Leonard Fournette | RB | Out | Illness | Fournette is out with illness | Dec 0 |
| Jaguars | Quincy Williams | OLB | Out for season | Hand | Williams is out for season with hand | Dec 4 |
| Jaguars | Josh Oliver | TE | Out for season | Back | Oliver is out for season with back | Nov 3 |
 Chiefs | Chad Henne | QB | Out for season | Ankle | Henne is out for season with ankle | Sep 1 |
| Chiefs | Mike Remmers | T | Out | Concussion | Remmers is out with concussion | Dec 5 |
| Chiefs | Taco Charlton | DE | Out | Ankle | Charlton is out with ankle | Dec 0 |
| Chiefs | Darrel Williams | RB | Out for season | Hamstring | Williams is out for season with hamstring | Dec 4 |
| Chiefs | Breeland Speaks | DE | Out for season | Knee | Speaks is out for season with knee | Sep 1 |
| Chiefs | Juan Thornhill | FS | Out for season | Knee | Thornhill is out for season with knee | Jan 2 |
 Raiders | Arden Key | DE | Out | Foot | Key is out with foot | Nov 3 |
| Raiders | Johnathan Abram | FS | Out for season | Shoulder | Abram is out for season with shoulder | Sep 3 |
| Raiders | Josh Jacobs | RB | Out | Shoulder | Jacobs is out with shoulder | Dec 6 |
 Chargers | Mike Pouncey | C | Out | Neck | Pouncey is out with neck | Oct 3 |
| Chargers | Michael Davis | CB | Suspended | Two games | Davis is suspended with suspension | Nov 5 |
 Rams | Troy Hill | CB | Out | Thumb | Hill is out with thumb | Dec 0 |
| Rams | Jalen Ramsey | CB | Out | Knee | Ramsey is out with knee | Dec 2 |
| Rams | A'Shawn Robinson | DT | Out | Shoulder | Robinson is out with shoulder | Dec 5 |
| Rams | Joseph Noteboom | G | Out for season | Torn ACL | Noteboom is out for season with knee | Oct 2 |
| Rams | Micah Kiser | ILB | Out | Pec | Kiser is out with pectoral | Sep 1 |
| Rams | Darrell Henderson | RB | Out | Ankle | Henderson is out with ankle | Dec 5 |
 Dolphins | Bobby McCain | FS | Out for season | Shoulder | McCain is out for season with shoulder | Nov 0 |
| Dolphins | Allen Hurns | WR | Out | Ankle/Neck | Hurns is out with ankle | Dec 0 |
| Dolphins | Byron Jones | CB | Out | Ankle | Jones is out with ankle | Dec 0 |
| Dolphins | Jakeem Grant | WR | Out for season | Ankle | Grant is out for season with ankle | Nov 3 |
| Dolphins | Xavien Howard | CB | Out for season | Knee | Howard is out for season with knee | Oct 2 |
| Dolphins | Kamu Grugier-Hill | OLB | Out for season | Back | Grugier-Hill is out for season with back | Dec 3 |
| Dolphins | Emmanuel Ogbah | DE | Out for season | Pec | Ogbah is out for season with pectoral | Nov 4 |
| Dolphins | Ricardo Louis | WR | Out for season | Knee | Louis is out for season with knee | Sep 1 |
| Dolphins | Cordrea Tankersley | CB | Out | Knee | Tankersley is out with knee | Sep 1 |
| Dolphins | Jomal Perry | CB | Out | Shoulder | Wiltz is out with shoulder | Dec 5 |
| Dolphins | Vince Biegel | OLB | Out | Elbow | Biegel is out with elbow | Dec 0 |
| Dolphins | Raekwon McMillan | ILB | Out for season | Hamstring | McMillan is out for season with hamstring | Dec 2 |
| Dolphins | Kalen Ballage | RB | Out for season | Leg | Ballage is out for season with leg | Dec 2 |
| Dolphins | Ken Webster | CB | Out for season | Ankle | Webster is out for season with ankle | Dec 4 |
| Dolphins | Myles Gaskin | RB | Out for season | Ankle | Gaskin is out for season with ankle | Dec 2 |
| Dolphins | Preston Williams | WR | Out for season | Knee | Williams is out for season with knee | Nov 1 |
 Vikings | Chad Beebe | WR | Out | Ankle | Beebe is out with ankle | Sep 3 |
| Vikings | Ben Gedeon | OLB | Out for season | Concussion | Gedeon is out for season with concussion | Dec 2 |
| Vikings | Mike Hughes | CB | Out for season | Neck | Hughes is out for season with neck | Jan 5 |
 Patriots | David Andrews | C | Out for season | Blood Clot | Andrews is out for season with blood clot | Sep 1 |
| Patriots | Marqise Lee | WR | Out | Shoulder | Lee is out with shoulder | Oct 2 |
| Patriots | Adrian Phillips | SS | Out | Arm | Phillips is out with arm | Sep 1 |
| Patriots | Beau Allen | NT | Out | Ankle | Allen is out with ankle | Dec 5 |
| Patriots | Jason McCourty | CB | Out | Groin | McCourty is out with groin | Jan 6 |
| Patriots | Tashawn Bower | DE | Out for season | Achilles | Bower is out for season with achilles | Sep 1 |
| Patriots | Gunner Olszewski | WR | Out for season | Ankle | Olszewski is out for season with ankle | Nov 3 |
| Patriots | Yodny Cajuste | T | Out | Quad | Cajuste is out with quad | Sep 1 |
| Patriots | Hjalte Froholdt | G | Out for season | Shoulder | Froholdt is out for season with shoulder | Sep 1 |
 Saints | Sheldon Rankins | DT | Out for season | Achilles | Rankins is out for season with achilles | Dec 4 |
| Saints | Austin Carr | WR | Out | Ankle | Carr is out with ankle | Nov 5 |
| Saints | Alex Anzalone | MLB | Out | Shoulder | Anzalone is out with shoulder | Sep 1 |
| Saints | Marcus Davenport | DE | Out for season | Foot | Davenport is out for season with foot | Dec 4 |
 Giants | Corey Coleman | WR | Out for season | Knee | Coleman is out for season with knee | Aug 6 |
| Giants | Evan Engram | TE | Out for season | Foot | Engram is out for season with foot | Dec 2 |
| Giants | Jabrill Peppers | SS | Out for season | Back | Peppers is out for season with back | Dec 6 |
| Giants | Sam Beal | CB | Out | Shoulder | Beal is out with shoulder | Dec 0 |
| Giants | Ryan Connelly | OLB | Out for season | Torn ACL | Connelly is out for season with knee | Sep 1 |
 Jets | C.J. Mosley | ILB | Out for season | Groin | Mosley is out for season with groin | Dec 2 |
| Jets | Ryan Griffin | TE | Out for season | Ankle | Griffin is out for season with ankle | Dec 4 |
| Jets | Joe Flacco | QB | Out | Neck | Flacco is out with neck | Oct 1 |
| Jets | Kenneth Dixon | RB | Out for season | Undisclosed | Dixon is out for season with undisclosed | Sep 1 |
| Jets | Alex Lewis | G | Out | Ankle | Lewis is out with ankle | Dec 5 |
| Jets | Greg Van Roten | G | Out for season | Toe | Van Roten is out for season with toe | Nov 3 |
| Jets | Quincy Wilson | CB | Out | Shoulder | Wilson is out with shoulder | Dec 5 |
| Jets | Nathan Shepherd | DE | Suspended | Suspension | Shepherd is suspended with suspension | Sep 2 |
| Jets | Chris Herndon IV | TE | Out for season | Ribs | Herndon is out for season with ribs | Nov 2 |
| Jets | Blake Cashman | ILB | Out | Shoulder | Cashman is out with shoulder | Nov 5 |
| Jets | Chuma Edoga | T | Out for season | Knee | Edoga is out for season with knee | Dec 2 |
 Eagles | Malik Jackson | DT | Out for season | Foot | Jackson is out for season with foot | Sep 2 |
| Eagles | Brandon Brooks | G | Out for season | Shoulder | Brooks is out for season with shoulder | Dec 1 |
| Eagles | Lane Johnson | T | Out | Ankle | Johnson is out with ankle | Jan 6 |
| Eagles | DeSean Jackson | WR | Out for season | Abdomen | Jackson is out for season with abdomen | Nov 3 |
| Eagles | Marquise Goodwin | WR | Out for season | Knee/Toe | Goodwin is out for season with knee | Dec 3 |
| Eagles | Alshon Jeffery | WR | Out for season | Foot | Jeffery is out for season with foot | Dec 2 |
| Eagles | Corey Clement | RB | Out | Shoulder | Clement is out with shoulder | Oct 5 |
| Eagles | Joe Ostman | DE | Out for season | Knee | Ostman is out for season with knee | Aug 2 |
| Eagles | Marcus Green | WR | Questionable | Hamstring | Green is questionable with hamstring | Aug 6 |
 Steelers | Ben Roethlisberger | QB | Out for season | Elbow | Roethlisberger is out for season with elbow | Sep 1 |
| Steelers | Eric Ebron | TE | Out for season | Ankle | Ebron is out for season with ankle | Nov 1 |
| Steelers | Maurkice Pouncey | C | Out | Knee | Pouncey is out with knee | Dec 2 |
| Steelers | James Conner | RB | Out | Thigh | Conner is out with thigh | Dec 5 |
| Steelers | Mason Rudolph | QB | Out for season | Shoulder | Rudolph is out for season with shoulder | Dec 2 |
| Steelers | Benny Snell Jr. | RB | Doubtful | Knee | Snell is doubtful with knee | Oct 4 |
 49ers | Travis Benjamin | WR | Out | Quad | Benjamin is out with quad | Oct 4 |
| 49ers | Jason Verrett | CB | Out | Knee | Verrett is out with knee | Oct 4 |
| 49ers | Weston Richburg | C | Out for season | Knee | Richburg is out for season with knee | Dec 4 |
| 49ers | Tom Compton | G | Out | Calf | Compton is out with calf | Dec 5 |
| 49ers | Trent Williams | T | Out for season | Personal | Williams is out for season with personal | Nov 4 |
| 49ers | Jerick McKinnon | RB | Out for season | Knee | McKinnon is out for season with knee | Sep 1 |
| 49ers | Ronald Blair III | DE | Out for season | Torn ACL | Blair is out for season with knee | Nov 3 |
| 49ers | Trent Taylor | WR | Out | Foot | Taylor is out with foot | Sep 5 |
| 49ers | D.J. Jones | DT | Out for season | Ankle | Jones is out for season with ankle | Dec 5 |
| 49ers | Dante Pettis | WR | Out | Healthy Scratch | Pettis is out | Feb 0 |
| 49ers | Jullian Taylor | DT | Out for season | Knee | Taylor is out for season with knee | Dec 1 |
| 49ers | Jalen Hurd | WR | Out | Back | Hurd is out with back | Oct 4 |
 Seahawks | Quinton Dunbar | CB | Out for season | Hamstring | Dunbar is out for season with hamstring | Dec 2 |
| Seahawks | Mike Iupati | G | Out | Neck | Iupati is out with neck | Jan 0 |
| Seahawks | Ethan Pocic | C | Out for season | Core | Pocic is out for season with core | Jan 4 |
| Seahawks | Chris Carson | RB | Out for season | Hip | Carson is out for season with hip | Dec 1 |
| Seahawks | Rashaad Penny | RB | Out for season | Knee | Penny is out for season with knee | Dec 1 |
| Seahawks | Will Dissly | TE | Out for season | Achilles | Dissly is out for season with achilles | Oct 3 |
| Seahawks | Marquise Blair | FS | Out | Ankle | Blair is out with ankle | Jan 0 |
 Buccaneers | Mike Evans | WR | Out for season | Hamstring | Evans is out for season with hamstring | Dec 3 |
| Buccaneers | Ryan Smith | CB | Suspended | Suspended | Smith is suspended with suspension | Sep 1 |
| Buccaneers | Justin Evans | SS | Out | Achilles | Evans is out with achilles | Sep 2 |
| Buccaneers | Chris Godwin | WR | Out | Hamstring | Godwin is out with hamstring | Dec 5 |
| Buccaneers | Jordan Whitehead | SS | Out for season | Hamstring | Whitehead is out for season with hamstring | Dec 4 |
| Buccaneers | Scotty Miller | WR | Out for season | Hamstring | Miller is out for season with hamstring | Dec 2 |
 Titans | Malcolm Butler | CB | Out for season | Wrist | Butler is out for season with wrist | Nov 3 |
| Titans | Cam Batson | WR | Out for season | Undisclosed | Batson is out for season with undisclosed | Sep 1 |
 Redskins | Ronald Darby | CB | Out for season | Hip | Darby is out for season with hip | Dec 2 |
| Redskins | Alex Smith | QB | Out | Leg | Smith is out with leg | Sep 1 |
| Redskins | Landon Collins | SS | Out | Shoulder | Collins is out with shoulder | Dec 5 |
| Redskins | Brandon Scherff | G | Out for season | Elbow/Shoulder | Scherff is out for season with elbow | Dec 2 |
| Redskins | Ryan Kerrigan | OLB | Out for season | Calf | Kerrigan is out for season with calf | Dec 1 |
| Redskins | Sean Davis | FS | Out | Shoulder | Davis is out with shoulder | Sep 2 |
| Redskins | Michael Liedtke | G | Out for season | Shoulder | Liedtke is out for season with shoulder | Aug 3 |
| Redskins | Fabian Moreau | CB | Out for season | Hamstring | Moreau is out for season with hamstring | Dec 5 |
| Redskins | Reuben Foster | ILB | Out for season | Knee | Foster is out for season with knee | Aug 6 |
| Redskins | Derrius Guice | RB | Out for season | Knee | Guice is out for season with knee | Dec 2 |
| Redskins | Trey Quinn | WR | Out for season | Concussion | Quinn is out for season with concussion | Dec 2 |
| Redskins | Troy Apke | FS | Out | Knee | Apke is out with knee | Dec 0 |
| Redskins | Terry McLaurin | WR | Out | Concussion | McLaurin is out with concussion | Dec 5 |
| Redskins | Bryce Love | RB | Out | Knee | Love is out with knee | Sep 4 |
| Redskins | Jimmy Moreland | CB | Out for season | Foot | Moreland is out for season with foot | Dec 3 |
| Redskins | Dwayne Haskins | QB | Out | Ankle | Haskins is out with ankle | Dec 1 |