 Cardinals | Chandler Jones | OLB | Out for season | Biceps | Chandler Jones (Biceps) is out for the season. | Oct 14 |
| Cardinals | Chris Banjo | FS | Out | Placed on Reserve/COVID-19 List. | Chris Banjo (Illness) is out this week. | Dec 31 |
| Cardinals | Larry Fitzgerald | WR | Out | Groin | Larry Fitzgerald (Groin) is out this week. | Jan 3 |
| Cardinals | Corey Peters | NT | Out for season | Knee | Corey Peters (Knee) is out for the season. | Nov 18 |
| Cardinals | Budda Baker | SS | Questionable | Neck | Budda Baker (Neck) is questionable this week. | Jan 2 |
| Cardinals | Christian Kirk | WR | Out | Placed on Reserve/COVID-19 List. | Christian Kirk (Illness) is out this week. | Jan 2 |
 Falcons | Alex Mack | C | Out | Placed on Reserve/COVID-19 List. | Alex Mack (Illness) is out this week. | Dec 31 |
| Falcons | Julio Jones | WR | Out | Hamstring | Julio Jones (Hamstring) is out this week. | Jan 1 |
| Falcons | Darqueze Dennard | CB | Out | Quad | Darqueze Dennard (Quad) is out this week. | Dec 18 |
| Falcons | Charles Harris | OLB | Questionable | Personal | Charles Harris (Personal) is questionable this week. | Jan 1 |
| Falcons | Damontae Kazee | SS | Out | Placed on IR. | Damontae Kazee (Achilles) is out this week. | Oct 7 |
| Falcons | Brandon Powell | WR | Out | Foot | Brandon Powell (Foot) is out this week. | Jan 1 |
| Falcons | Olamide Zaccheaus | WR | Out | Placed on IR. | Olamide Zaccheaus (Toe) is out this week. | Dec 5 |
 Ravens | D.J. Fluker | G | Questionable | Knee | D.J. Fluker (Knee) is questionable this week. | Jan 1 |
| Ravens | Marcus Peters | CB | Questionable | Back | Marcus Peters (Back) is questionable this week. | Jan 15 |
| Ravens | Robert Griffin III | QB | Out | Placed on IR. | Robert Griffin III (Hamstring) is out this week. | Dec 4 |
| Ravens | DeAndrew White | WR | Out for season | Placed on IR. | White is out for season with undisclosed | Sep 3 |
| Ravens | Tavon Young | CB | Out for season | Knee | Tavon Young (Knee) is out for the season. | Sep 21 |
| Ravens | Nick Boyle | TE | Out for season | Knee | Nick Boyle (Knee) is out for the season. | Nov 16 |
| Ravens | Ronnie Stanley | T | Out for season | Ankle | Ronnie Stanley (Ankle) is out for the season. | Nov 2 |
| Ravens | Mark Ingram II | RB | Out | Undisclosed | Mark Ingram (Undisclosed) is out this week. | Jan 16 |
| Ravens | Ben Bredeson | G | Out | Placed on IR. | Ben Bredeson (Knee) is out this week. | Jan 9 |
 Bills | Darryl Johnson | DE | Questionable | Knee | Darryl Johnson (Knee) is questionable this week. | Jan 15 |
| Bills | Zack Moss | RB | Out | Ankle | Zack Moss (Ankle) is out this week. | Jan 11 |
 Panthers | Mike Davis | RB | Out | Ankle | Mike Davis (Ankle) is out this week. | Jan 3 |
| Panthers | Russell Okung | T | Doubtful | Calf | Russell Okung (Calf) is doubtful this week. | Dec 25 |
| Panthers | Christian McCaffrey | RB | Out | Quad | Christian McCaffrey (Quad) is out this week. | Jan 3 |
| Panthers | Reggie Bonnafon | RB | Out | Placed on IR. | Reggie Bonnafon (Ankle) is out this week. | Dec 8 |
| Panthers | Keith Kirkwood | WR | Out | Placed on IR. | Keith Kirkwood (Collarbone) is out this week. | Oct 20 |
| Panthers | Greg Little | T | Out | Placed on IR. | Greg Little (Ankle) is out this week. | Dec 17 |
| Panthers | Ventell Bryant | WR | Out | Placed on IR. | Ventell Bryant (Knee) is out this week. | Sep 22 |
| Panthers | Brian Burns | DE | Doubtful | Shoulder | Brian Burns (Shoulder) is doubtful this week. | Jan 1 |
| Panthers | Troy Pride Jr. | CB | Doubtful | Hip | Troy Pride (Hip) is doubtful this week. | Dec 25 |
| Panthers | Omar Bayless | WR | Out for season | Placed on IR. | Bayless is out for season with knee | Sep 3 |
 Bears | Buster Skrine | CB | Out | Concussion | Buster Skrine (Concussion) is out this week. | Dec 11 |
| Bears | Dwayne Harris | WR | Out | Placed on IR. | Dwayne Harris (Triceps) is out this week. | Dec 1 |
| Bears | Bobby Massie | T | Out | Placed on IR. | Bobby Massie (Knee) is out this week. | Nov 4 |
| Bears | Tarik Cohen | RB | Out for season | Knee | Tarik Cohen (Knee) is out for the season. | Jan 6 |
| Bears | Roquan Smith | ILB | Out | Elbow | Roquan Smith (Elbow) is out this week. | Jan 9 |
| Bears | Josh Woods | ILB | Questionable | Toe | Josh Woods (Toe) is questionable this week. | Jan 8 |
| Bears | Darion Clark | TE | Out | Placed on IR. | Darion Clark (Undisclosed) is out this week. | Sep 29 |
| Bears | Jaylon Johnson | CB | Questionable | Shoulder | Jaylon Johnson (Shoulder) is questionable this week. | Jan 8 |
| Bears | Darnell Mooney | WR | Out | Ankle | Darnell Mooney (Ankle) is out this week. | Jan 9 |
 Bengals | C.J. Uzomah | TE | Out for season | Achilles | CJ Uzomah (Achilles) is Out for Season this week. | Sep 18 |
| Bengals | Geno Atkins | DT | Out | Placed on IR. | Geno Atkins (Shoulder) is out this week. | Dec 16 |
| Bengals | A.J. Green | WR | Out for season | Ankle | Green is out for season with ankle | Dec 23 |
| Bengals | B.J. Finney | C | Out | Abdomen | B.J. Finney (Abdomen) is out this week. | Jan 1 |
| Bengals | Mackensie Alexander | CB | Out | Illness | Mackensie Alexander (Illness) is out this week. | Jan 3 |
| Bengals | William Jackson III | CB | Out | Concussion | William Jackson (Concussion) is out this week. | Jan 1 |
| Bengals | John Ross | WR | Out | Placed on IR. | John Ross (Foot) is out this week. | Nov 15 |
| Bengals | Joe Mixon | RB | Out | Placed on IR. | Joe Mixon (Foot) is out this week. | Nov 21 |
| Bengals | Auden Tate | WR | Out | Placed on IR. | Auden Tate (Shoulder) is out this week. | Dec 2 |
| Bengals | Jonah Williams | T | Out | Placed on IR. | Jonah Williams (Knee) is out this week. | Dec 9 |
| Bengals | Amani Bledsoe | DE | Out | Placed on Reserve/COVID-19 List. | Amani Bledsoe (Illness) is out this week. | Dec 6 |
| Bengals | Joe Burrow | QB | Out for season | Knee | Joe Burrow (Knee) is out for the season. | Nov 23 |
| Bengals | Logan Wilson | ILB | Out | Ankle | Logan Wilson (Ankle) is out this week. | Dec 20 |
 Browns | Odell Beckham Jr. | WR | Out for season | Knee | Odell Beckham (Knee) is out for the season. | Oct 26 |
| Browns | Jack Conklin | T | Questionable | Knee | Jack Conklin (Knee) is questionable this week. | Jan 8 |
| Browns | B.J. Goodson | ILB | Questionable | Shoulder | B.J. Goodson (Shoulder) is questionable this week. | Jan 15 |
| Browns | JoJo Natson | WR | Out | Placed on IR. | Jojo Natson (Knee) is out this week. | Sep 28 |
| Browns | Taywan Taylor | WR | Out | Placed on IR. | Taywan Taylor (Neck) is out this week. | Dec 8 |
| Browns | Javon Patterson | C | Out | Placed on Reserve/COVID-19 List. | Javon Patterson (Illness) is out this week. | Jan 5 |
| Browns | Greedy Williams | CB | Out | Placed on IR. | Greedy Williams (Shoulder) is out this week. | Oct 12 |
| Browns | Nick Harris | C | Out | Knee | Nick Harris (Knee) is out this week. | Jan 1 |
| Browns | Elijah Benton | SS | Out | Placed on Reserve/COVID-19 List. | Elijah Benton (Illness) is out this week. | Jan 5 |
| Browns | Jovante Moffatt | SS | Out | Placed on Reserve/COVID-19 List. | Jovante Moffatt (Illness) is out this week. | Jan 8 |
 Cowboys | La'el Collins | T | Out | Placed on IR. | La'el Collins (Hip) is out this week. | Oct 4 |
| Cowboys | Zack Martin | G | Out | Placed on IR. | Zack Martin (Calf) is out this week. | Dec 7 |
| Cowboys | Tyron Smith | T | Out for season | Neck | Tyron Smith (Neck) is out for the season. | Oct 9 |
| Cowboys | Antwaun Woods | DT | Out | Placed on IR. | Antwaun Woods (Ankle) is out this week. | Dec 26 |
| Cowboys | Dak Prescott | QB | Out for season | Ankle | Dak Prescott (Ankle) is out for the season. | Oct 27 |
| Cowboys | Darian Thompson | FS | Questionable | Concussion | Darian Thompson (Concussion) is questionable this week. | Jan 1 |
| Cowboys | Rashard Robinson | CB | Out | Knee | Rashard Robinson (Knee) is out this week. | Dec 25 |
| Cowboys | Blake Jarwin | TE | Out | Placed on IR. | Blake Jarwin (Knee) is Out this week. | Sep 15 |
| Cowboys | Xavier Woods | FS | Questionable | Ribs | Xavier Woods (Ribs) is questionable this week. | Jan 1 |
| Cowboys | Leighton Vander Esch | OLB | Out | Ankle | Leighton Vander Esch (Ankle) is out this week. | Dec 25 |
 Broncos | DeShawn Williams | DT | Questionable | Knee | DeShawn Williams (Knee) is questionable this week. | Dec 25 |
| Broncos | Anthony Chickillo | OLB | Questionable | Ribs | Anthony Chickillo (Ribs) is questionable this week. | Jan 1 |
| Broncos | Jurrell Casey | DT | Out | Placed on IR. | Jurrell Casey (Biceps) is out this week. | Sep 28 |
| Broncos | Von Miller | OLB | Out | Ankle | Von Miller (Ankle) is out this week. | Oct 30 |
| Broncos | Mike Purcell | NT | Out for season | Foot | Mike Purcell (Foot) is out for the season. | Oct 26 |
| Broncos | Graham Glasgow | G | Questionable | Foot | Graham Glasgow (Foot) is questionable this week. | Dec 17 |
| Broncos | Phillip Lindsay | RB | Out | Placed on IR. | Phillip Lindsay (Knee) is out this week. | Dec 26 |
| Broncos | Courtland Sutton | WR | Out for season | Knee | Courtland Sutton (Knee) is out for the season. | Oct 30 |
| Broncos | Bradley Chubb | DE | Questionable | Ankle | Bradley Chubb (Ankle) is questionable this week. | Jan 1 |
| Broncos | Trey Marshall | SS | Questionable | Quad | Trey Marshall (Quad) is questionable this week. | Jan 1 |
| Broncos | KJ Hamler | WR | Out | Concussion | KJ Hamler (Concussion) is out this week. | Jan 1 |
| Broncos | Albert Okwuegbunam | TE | Out for season | Knee | Albert Okwuegbunam (Knee) is out for the season. | Nov 9 |
 Lions | Jamie Collins Sr. | OLB | Questionable | Neck | Jamie Collins (Neck) is questionable this week. | Dec 24 |
| Lions | Justin Coleman | CB | Out | Placed on IR. | Justin Coleman (Undisclosed) is Out this week. | Sep 15 |
| Lions | Danny Shelton | DT | Out | Placed on IR. | Danny Shelton (Undisclosed) is out this week. | Dec 2 |
| Lions | Desmond Trufant | CB | Out | Placed on IR. | Desmond Trufant (Undisclosed) is out this week. | Dec 2 |
| Lions | Trey Flowers | DE | Out | Placed on IR. | Trey Flowers (Undisclosed) is out this week. | Nov 2 |
| Lions | Darryl Roberts | CB | Out | Placed on IR. | Darryl Roberts (Groin) is out this week. | Nov 7 |
| Lions | Halapoulivaati Vaitai | T | Questionable | Concussion | Halapoulivaati Vaitai (Concussion) is questionable this week. | Dec 24 |
| Lions | Taylor Decker | T | Questionable | Groin | Taylor Decker (Groin) is questionable this week. | Dec 24 |
| Lions | Joe Dahl | G | Out | Back | Joe Dahl (Back) is out this week. | Jan 1 |
| Lions | Kenny Golladay | WR | Out | Hip | Kenny Golladay (Hip) is out this week. | Dec 31 |
| Lions | Frank Ragnow | C | Questionable | Throat | Frank Ragnow (Throat) is questionable this week. | Dec 24 |
| Lions | Tyrell Crosby | T | Out | Ankle | Tyrell Crosby (Ankle) is out this week. | Jan 1 |
| Lions | Jeff Okudah | CB | Out for season | Groin | Jeffrey Okudah (Groin) is out for the season. | Dec 12 |
| Lions | Julian Okwara | DE | Out | Placed on IR. | Julian Okwara (Leg) is out this week. | Oct 21 |
 Packers | Corey Linsley | C | Out | Placed on IR. | Corey Linsley (Knee) is out this week. | Dec 5 |
| Packers | David Bakhtiari | T | Out for season | Knee | David Bakhtiari (Knee) is out for the season. | Jan 1 |
| Packers | James Burgess Jr. | OLB | Out | Placed on IR. | James Burgess (Hamstring) is out this week. | Nov 25 |
| Packers | Tyler Ervin | RB | Out | Placed on IR. | Tyler Ervin (Ribs) is out this week. | Dec 9 |
| Packers | Billy Winn | DE | Out | Placed on IR. | Billy Winn (Triceps) is out this week. | Dec 8 |
| Packers | Will Redmond | SS | Out | Concussion | Will Redmond (Concussion) is out this week. | Dec 25 |
| Packers | Montravius Adams | DE | Out | Placed on IR. | Montravius Adams (Toe) is out this week. | Nov 25 |
| Packers | Raven Greene | FS | Out | Placed on IR. | Raven Greene (Undisclosed) is out this week. | Dec 9 |
| Packers | John Lovett | QB | Out for season | Knee | John Lovett (Knee) is out for the season. | Nov 13 |
| Packers | Josiah Deguara | TE | Out for season | Knee | Josiah Deguara (Knee) is out for the season. | Oct 6 |
| Packers | Simon Stepaniak | G | Questionable | Knee | Simon Stepaniak (Knee) is questionable this week. | Jan 1 |
| Packers | Patrick Taylor Jr. | RB | Out | Placed on IR. | Patrick Taylor (Undisclosed) is out this week. | Sep 22 |
 Texans | Michael Thomas | SS | Out | Placed on IR. | Michael Thomas (Shoulder) is out this week. | Nov 21 |
| Texans | Brent Qvale | T | Doubtful | Concussion | Brent Qvale (Concussion) is doubtful this week. | Jan 1 |
| Texans | Duke Johnson Jr. | RB | Out | Neck | Duke Johnson (Neck) is out this week. | Jan 3 |
| Texans | Bradley Roby | CB | Out | Suspended six games. | Bradley Roby (Undisclosed) is out this week. | Dec 1 |
| Texans | Whitney Mercilus | OLB | Out | Placed on Reserve/COVID-19 List. | Whitney Mercilus (Illness) is out this week. | Dec 25 |
| Texans | Randall Cobb | WR | Out | Placed on IR. | Randall Cobb (Toe) is out this week. | Nov 25 |
| Texans | Laremy Tunsil | T | Out | Ankle | Laremy Tunsil (Ankle) is out this week. | Jan 1 |
| Texans | Eric Murray | FS | Out | Placed on Reserve/COVID-19 List. | Eric Murray (Illness) is out this week. | Dec 27 |
| Texans | Phillip Gaines | CB | Questionable | Knee | Phillip Gaines (Knee) is questionable this week. | Dec 25 |
| Texans | Will Fuller V | WR | Out | Suspended six games. | Will Fuller (Suspension) is out this week. | Nov 30 |
| Texans | Justin Reid | SS | Out for season | Hand | Justin Reid (Hand) is out for the season. | Dec 16 |
| Texans | Cullen Gillaspia | RB | Out | Placed on IR. | Cullen Gillaspia (Back) is out this week. | Dec 5 |
| Texans | Hjalte Froholdt | G | Out | Placed on Reserve/COVID-19 List. | Hjalte Froholdt (Illness) is out this week. | Dec 17 |
| Texans | Tytus Howard | T | Out | Placed on IR. | Tytus Howard (Undisclosed) is out this week. | Dec 23 |
 Colts | Anthony Castonzo | T | Out for season | Ankle | Anthony Castonzo (Ankle) is out for the season. | Dec 30 |
| Colts | DeForest Buckner | DT | Questionable | Ankle | DeForest Buckner (Ankle) is questionable this week. | Jan 7 |
| Colts | Will Holden | T | Out | Ankle | Will Holden (Ankle) is out this week. | Jan 1 |
| Colts | Marlon Mack | RB | Out | Placed on IR. | Marlon Mack (Achilles) is Out this week. | Sep 16 |
| Colts | Malik Hooker | FS | Out for season | Achilles | Malik Hooker (Achilles) is Out for Season this week. | Sep 21 |
| Colts | Jordan Wilkins | RB | Out | Placed on Reserve/COVID-19 List. | Jordan Wilkins (Illness) is out this week. | Jan 3 |
| Colts | Parris Campbell | WR | Out | Knee | Parris Campbell (Knee) is out this week. | Sep 29 |
| Colts | Khari Willis | SS | Out | Concussion | Khari Willis (Concussion) is out this week. | Jan 1 |
| Colts | Rock Ya-Sin | CB | Out | Concussion | Rock Ya-Sin (Concussion) is out this week. | Jan 1 |
 Jaguars | D.J. Hayden | CB | Out | Placed on IR. | D.J. Hayden (Hamstring) is out this week. | Oct 7 |
| Jaguars | Chris Thompson | RB | Out | Placed on IR. | Chris Thompson (Back) is out this week. | Nov 17 |
| Jaguars | Abry Jones | DT | Out | Placed on IR. | Abry Jones (Ankle) is out this week. | Oct 22 |
| Jaguars | Dede Westbrook | WR | Out for season | Knee | Dede Westbrook (Knee) is out for the season. | Nov 3 |
| Jaguars | D.J. Chark Jr. | WR | Out | Shin | DJ Chark (Shin) is out this week. | Jan 1 |
| Jaguars | Josh Allen | DE | Out | Placed on IR. | Josh Allen (Knee) is out this week. | Nov 25 |
| Jaguars | Ryquell Armstead | RB | Out | Placed on Reserve/COVID-19 list | Ryquell Armstead (Illness) is Out this week. | Sep 7 |
| Jaguars | Andrew Wingard | FS | Out | Placed on IR. | Andrew Wingard (Core) is out this week. | Nov 13 |
| Jaguars | Josh Oliver | TE | Out | Placed on IR. | Josh Oliver (Undisclosed) is out this week. | Dec 5 |
| Jaguars | C.J. Henderson | CB | Out | Placed on IR. | C.J. Henderson (Undisclosed) is out this week. | Nov 19 |
| Jaguars | Daniel Thomas | SS | Out | Placed on IR. | Daniel Thomas (Arm) is out this week. | Nov 25 |
| Jaguars | Collin Johnson | WR | Out | Hamstring | Collin Johnson (Hamstring) is out this week. | Jan 1 |
| Jaguars | Chris Claybrooks | CB | Out | Placed on IR. | Chris Claybrooks (Core) is out this week. | Nov 27 |
| Jaguars | James Robinson | RB | Out | Ankle | James Robinson (Ankle) is out this week. | Jan 1 |
 Chiefs | Sammy Watkins | WR | Out | Calf | Sammy Watkins (Calf) is out this week. | Jan 15 |
| Chiefs | Mitchell Schwartz | T | Out | Placed on IR. | Mitchell Schwartz (Back) is out this week. | Nov 21 |
| Chiefs | Anthony Hitchens | ILB | Out | Placed on Reserve/COVID-19 List. | Anthony Hitchens (Illness) is out this week. | Dec 22 |
| Chiefs | Taco Charlton | DE | Out | Placed on IR. | Taco Charlton (Knee) is out this week. | Nov 21 |
| Chiefs | Rashad Fenton | CB | Questionable | Ankle | Rashad Fenton (Ankle) is questionable this week. | Jan 15 |
| Chiefs | Clyde Edwards-Helaire | RB | Out | Ankle | Clyde Edwards-Helaire (Ankle) is out this week. | Jan 17 |
| Chiefs | Willie Gay Jr. | OLB | Out | Ankle | Willie Gay (Ankle) is out this week. | Jan 15 |
| Chiefs | Michael Danna | DE | Out | Placed on Reserve/COVID-19 List. | Mike Danna (Illness) is out this week. | Jan 6 |
 Raiders | Richie Incognito | G | Out | Placed on IR. | Richie Incognito (Achilles) is out this week. | Sep 23 |
| Raiders | Denzelle Good | G | Questionable | Ankle | Denzelle Good (Ankle) is questionable this week. | Jan 1 |
| Raiders | Tyrell Williams | WR | Out for season | Torn Labrum | Williams is out for season with shoulder | Sep 3 |
| Raiders | Trent Brown | T | Out | Knee | Trenton Brown (Knee) is out this week. | Jan 1 |
| Raiders | Lamarcus Joyner | CB | Questionable | Thigh | Lamarcus Joyner (Thigh) is questionable this week. | Jan 1 |
| Raiders | Nick Kwiatkoski | ILB | Out | Placed on Reserve/COVID-19 List. | Nick Kwiatkoski (Illness) is out this week. | Dec 23 |
| Raiders | Maliek Collins | DT | Out | Placed on IR. | Maliek Collins (Undisclosed) is out this week. | Dec 2 |
| Raiders | Maurice Hurst | DT | Questionable | Calf | Maurice Hurst (Calf) is questionable this week. | Dec 24 |
| Raiders | Tanner Muse | LB | Out for season | Toe | Tanner Muse (Toe) is out for the season. | Nov 3 |
 Chargers | Ryan Groy | G | Out for season | Shoulder | Ryan Groy (Shoulder) is out for the season. | Dec 11 |
| Chargers | Mike Pouncey | C | Out for season | Placed on IR. | Mike Pouncey (Hip) is Out for Season this week. | Sep 17 |
| Chargers | Virgil Green | TE | Out | Placed on IR. | Virgil Green (Ankle) is out this week. | Oct 29 |
| Chargers | Melvin Ingram | DE | Out | Placed on IR. | Melvin Ingram (Knee) is out this week. | Nov 27 |
| Chargers | Jahleel Addae | FS | Questionable | Calf | Jahleel Addae (Calf) is questionable this week. | Jan 1 |
| Chargers | Bryan Bulaga | T | Out | Foot | Bryan Bulaga (Foot) is out this week. | Jan 1 |
| Chargers | Casey Hayward | CB | Out | Hamstring | Casey Hayward (Hamstring) is out this week. | Jan 1 |
| Chargers | Keenan Allen | WR | Out | Placed on Reserve/COVID-19 List. | Keenan Allen (Illness) is out this week. | Dec 31 |
| Chargers | Joey Bosa | DE | Out | Shin | Joey Bosa (Shin) is out this week. | Dec 25 |
| Chargers | Rayshawn Jenkins | SS | Out | Ankle | Rayshawn Jenkins (Ankle) is out this week. | Jan 1 |
| Chargers | Sam Tevi | T | Questionable | Knee | Samiuela Tevi (Knee) is questionable this week. | Jan 1 |
 Rams | Cooper Kupp | WR | Out | Knee | Cooper Kupp (Knee) is out this week. | Jan 16 |
| Rams | John Wolford | QB | Out | Neck | John Wolford (Neck) is out this week. | Jan 15 |
| Rams | David Edwards | G | Questionable | Ankle | David Edwards (Ankle) is questionable this week. | Jan 8 |
| Rams | Terrell Lewis | LB | Out | Ankle | Terrell Lewis (Ankle) is out this week. | Jan 15 |
| Rams | Jonah Williams | DE | Questionable | Stinger | Jonah Williams (Stinger) is questionable this week. | Nov 13 |
 Dolphins | Ryan Fitzpatrick | QB | Out | Placed on Reserve/COVID-19 List. | Ryan Fitzpatrick (Illness) is out this week. | Dec 31 |
| Dolphins | Jakeem Grant | WR | Out | Ankle | Jakeem Grant (Ankle) is out this week. | Jan 3 |
| Dolphins | Shaq Lawson | OLB | Questionable | Shoulder | Shaq Lawson (Shoulder) is questionable this week. | Dec 24 |
| Dolphins | Davon Godchaux | NT | Out | Placed on IR. | Davon Godchaux (Biceps) is out this week. | Oct 16 |
| Dolphins | Preston Williams | WR | Out | Placed on IR. | Preston Williams (Foot) is out this week. | Nov 11 |
| Dolphins | Solomon Kindley | G | Questionable | Foot | Solomon Kindley (Foot) is questionable this week. | Jan 1 |
 Vikings | Anthony Barr | OLB | Out | Placed on IR. | Anthony Barr (Pectoral) is out this week. | Sep 21 |
| Vikings | Kyle Rudolph | TE | Out | Placed on IR. | Kyle Rudolph (Foot) is out this week. | Dec 29 |
| Vikings | Eric Kendricks | ILB | Out | Calf | Eric Kendricks (Calf) is out this week. | Dec 11 |
| Vikings | Danielle Hunter | DE | Out | Placed on IR. | Danielle Hunter (Neck) is Out this week. | Sep 9 |
| Vikings | Dalvin Cook | RB | Out | Personal | Dalvin Cook (Personal) is out this week. | Dec 30 |
| Vikings | Ifeadi Odenigbo | DE | Out | Ankle | Ifeadi Odenigbo (Ankle) is out this week. | Jan 1 |
| Vikings | Mike Hughes | CB | Out | Placed on IR. | Mike Hughes (Neck) is out this week. | Oct 30 |
| Vikings | Jalyn Holmes | DE | Out | Groin | Jalyn Holmes (Groin) is out this week. | Dec 24 |
| Vikings | Chris Jones | CB | Out | Groin | Chris Jones (Groin) is out this week. | Jan 1 |
| Vikings | Cameron Dantzler | CB | Out | Foot | Cameron Dantzler (Foot) is out this week. | Jan 1 |
| Vikings | Troy Dye | ILB | Out | Placed on IR. | Troy Dye (Foot) is out this week. | Sep 24 |
 Patriots | Rex Burkhead | RB | Out | Placed on IR. | Rex Burkhead (Knee) is out this week. | Nov 29 |
| Patriots | Devin McCourty | FS | Questionable | Shoulder | Devin McCourty (Shoulder) is questionable this week. | Jan 1 |
| Patriots | Joe Cardona | LS | Questionable | Ankle | Joe Cardona (Ankle) is questionable this week. | Dec 28 |
| Patriots | David Andrews | C | Out | Calf | David Andrews (Calf) is out this week. | Jan 1 |
| Patriots | Shaq Mason | G | Out | Calf | Shaquille Mason (Calf) is out this week. | Jan 1 |
| Patriots | Lawrence Guy | DT | Questionable | Shoulder | Lawrence Guy (Shoulder) is questionable this week. | Dec 9 |
| Patriots | Brandon Copeland | OLB | Out for season | Pectoral | Brandon Copeland (Pectoral) is out for the season. | Oct 26 |
| Patriots | Justin Bethel | CB | Questionable | Neck | Justin Bethel (Neck) is questionable this week. | Jan 1 |
| Patriots | Stephon Gilmore | CB | Out | Placed on IR. | Stephon Gilmore (Quad) is out this week. | Dec 23 |
| Patriots | Shilique Calhoun | OLB | Questionable | Knee | Shilique Calhoun (Knee) is questionable this week. | Dec 28 |
| Patriots | Quincy Adeboyejo | WR | Out | Undisclosed | Quincy Adeboyejo (Undisclosed) is Out this week. | Sep 15 |
| Patriots | Jermaine Eluemunor | T | Questionable | Ankle | Jermaine Eluemunor (Ankle) is questionable this week. | Dec 18 |
| Patriots | Tashawn Bower | DE | Out | Placed on IR. | Tashawn Bower (Ankle) is out this week. | Dec 31 |
| Patriots | Adam Butler | DT | Questionable | Shoulder | Adam Butler (Shoulder) is Questionable this week. | Sep 18 |
| Patriots | Isaiah Wynn | T | Out | Placed on IR. | Isaiah Wynn (Ankle) is out this week. | Nov 29 |
| Patriots | J.C. Jackson | CB | Questionable | Hip | Jerald Jackson (Hip) is questionable this week. | Dec 4 |
| Patriots | Ja'Whaun Bentley | ILB | Questionable | Shoulder | Ja'Whaun Bentley (Shoulder) is questionable this week. | Dec 28 |
| Patriots | Ryan Izzo | TE | Out | Placed on IR. | Ryan Izzo (Hamstring) is out this week. | Dec 10 |
| Patriots | Terez Hall | OLB | Questionable | Ankle | Terez Hall (Ankle) is questionable this week. | Jan 1 |
| Patriots | Yodny Cajuste | T | Out | Placed on IR. | Yodny Cajuste (Knee) is Out this week. | Sep 10 |
| Patriots | Byron Cowart | DT | Questionable | Back | Byron Cowart (Back) is questionable this week. | Dec 4 |
| Patriots | Josh Uche | OLB | Out | Placed on IR. | Josh Uche (Undisclosed) is out this week. | Dec 31 |
| Patriots | Anfernee Jennings | OLB | Questionable | Shoulder | Anfernee Jennings (Shoulder) is questionable this week. | Dec 28 |
| Patriots | Justin Herron | T | Questionable | Ankle | Justin Herron (Ankle) is questionable this week. | Dec 18 |
 Saints | Bennie Fowler III | WR | Out | Placed on IR. | Bennie Fowler (Shoulder) is out this week. | Oct 23 |
| Saints | Patrick Robinson | CB | Out | Hamstring | Patrick Robinson (Hamstring) is out this week. | Jan 15 |
| Saints | Latavius Murray | RB | Out | Quad | Latavius Murray (Quad) is out this week. | Jan 17 |
| Saints | Kwon Alexander | OLB | Out for season | Achilles | Kwon Alexander (Achilles) is out for the season. | Dec 26 |
| Saints | Sheldon Rankins | DT | Out | Placed on IR. | Sheldon Rankins (Thumb) is out this week. | Nov 6 |
| Saints | Justin Hardee | CB | Out | Placed on IR. | Justin Hardee (Groin) is out this week. | Nov 6 |
| Saints | Taysom Hill | QB | Out | Knee | Taysom Hill (Knee) is out this week. | Jan 17 |
 Giants | Golden Tate | WR | Out | Calf | Golden Tate (Calf) is out this week. | Jan 3 |
| Giants | Cody Core | WR | Out | Placed on IR. | Cody Core (Achilles) is out this week. | Sep 29 |
| Giants | Elijhaa Penny | FB | Out | Illness | Elijhaa Penny (Illness) is out this week. | Jan 1 |
| Giants | Ryan Lewis | CB | Out | Placed on IR. | Ryan Lewis (Hamstring) is out this week. | Nov 6 |
| Giants | Saquon Barkley | RB | Out | Knee | Saquon Barkley (Knee) is out this week. | Sep 22 |
| Giants | David Sills V | WR | Out | Placed on IR. | David Sills (Foot) is out this week. | Sep 22 |
| Giants | Cam Brown | OLB | Questionable | Illness | Cam Brown (Illness) is questionable this week. | Jan 1 |
 Jets | Frank Gore | RB | Out | Lungs | Frank Gore (Lungs) is out this week. | Jan 2 |
| Jets | Sam Ficken | K | Out | Placed on IR. | Sam Ficken (Groin) is out this week. | Nov 25 |
| Jets | Bless Austin | CB | Questionable | Illness | Blessuan Austin (Illness) is questionable this week. | Jan 1 |
| Jets | La'Mical Perine | RB | Out | Placed on Reserve/COVID-19 List. | Lamical Perine (Illness) is out this week. | Dec 30 |
| Jets | Javelin Guidry | DB | Questionable | Hamstring | Javelin Guidry (Hamstring) is questionable this week. | Dec 25 |
 Eagles | Nickell Robey-Coleman | CB | Out | Placed on Reserve/COVID-19 List. | Nickell Robey (Illness) is out this week. | Jan 3 |
| Eagles | Lane Johnson | T | Out | Placed on IR. | Lane Johnson (Ankle) is out this week. | Dec 2 |
| Eagles | Jason Peters | T | Out for season | Toe | Jason Peters (Toe) is out for the season. | Dec 11 |
| Eagles | Fletcher Cox | DT | Out | Neck | Fletcher Cox (Neck) is out this week. | Jan 1 |
| Eagles | DeSean Jackson | WR | Out | Ankle | DeSean Jackson (Ankle) is out this week. | Jan 1 |
| Eagles | Richard Rodgers | TE | Out | Ankle | Richard Rodgers (Ankle) is out this week. | Dec 25 |
| Eagles | Hassan Ridgeway | DT | Out | Placed on IR. | Hassan Ridgeway (Biceps) is out this week. | Oct 26 |
| Eagles | Alshon Jeffery | WR | Out | Undisclosed | Alshon Jeffery (Undisclosed) is out this week. | Jan 3 |
| Eagles | Josh Perkins | TE | Out | Placed on IR. | Josh Perkins (Undisclosed) is out this week. | Sep 22 |
| Eagles | Derek Barnett | DE | Out | Calf | Derek Barnett (Calf) is out this week. | Jan 1 |
| Eagles | Duke Riley | OLB | Out | Biceps | Duke Riley (Biceps) is out this week. | Jan 1 |
| Eagles | Dallas Goedert | TE | Out | Calf | Dallas Goedert (Calf) is out this week. | Jan 1 |
| Eagles | Jordan Mailata | T | Out | Concussion | Lafoga Mailata (Concussion) is out this week. | Jan 1 |
| Eagles | Miles Sanders | RB | Out | Knee | Miles Sanders (Knee) is out this week. | Jan 1 |
| Eagles | Davion Taylor | OLB | Out | Placed on IR. | Davion Taylor (Undisclosed) is out this week. | Dec 9 |
| Eagles | Shaun Bradley | ILB | Out | Neck | Shaun Bradley (Neck) is out this week. | Jan 1 |
| Eagles | Michael Jacquet | DB | Questionable | Calf | Michael Jacquet (Calf) is questionable this week. | Jan 1 |
 Steelers | Bud Dupree | OLB | Out for season | Knee | Bud Dupree (Knee) is out for the season. | Dec 3 |
| Steelers | Joe Haden | CB | Out | Placed on Reserve/COVID-19 List. | Joe Haden (Illness) is out this week. | Jan 2 |
| Steelers | Trevor Williams | CB | Out | Ribs | Trevor Williams (Ribs) is out this week. | Oct 2 |
| Steelers | Trey Edmunds | RB | Out | Placed on IR. | Trey Edmunds (Undisclosed) is out this week. | Dec 7 |
| Steelers | Devin Bush Jr. | ILB | Out for season | Leg | Devin Bush (Leg) is out for the season. | Oct 19 |
| Steelers | Benny Snell Jr. | RB | Doubtful | Knee | Snell is doubtful with knee | Oct 31 |
| Steelers | Zach Gentry | TE | Out | Placed on IR. | Zach Gentry (Knee) is out this week. | Nov 24 |
 49ers | Jimmy Garoppolo | QB | Out | Ankle | Jimmy Garoppolo (Ankle) is out this week. | Dec 30 |
| 49ers | K'Waun Williams | CB | Out | Shin | K'Waun Williams (Shin) is out this week. | Jan 1 |
| 49ers | Raheem Mostert | RB | Out | Ankle | Raheem Mostert (Ankle) is out this week. | Dec 24 |
| 49ers | Mark Nzeocha | OLB | Questionable | Illness | Mark Nzeocha (Illness) is questionable this week. | Jan 1 |
| 49ers | Robbie Gould | K | Out | Placed on Reserve/COVID-19 List. | Robbie Gould (Illness) is out this week. | Dec 30 |
| 49ers | Jaquiski Tartt | SS | Out | Placed on IR. | Jaquiski Tartt (Groin) is out this week. | Nov 11 |
| 49ers | Richard Sherman | CB | Out | Calf | Richard Sherman (Calf) is out this week. | Dec 24 |
| 49ers | Nick Mullens | QB | Out | Elbow | Nick Mullens (Elbow) is out this week. | Dec 24 |
| 49ers | Tarvarius Moore | FS | Questionable | Knee | Tarvarius Moore (Knee) is questionable this week. | Dec 24 |
| 49ers | Emmanuel Moseley | CB | Questionable | Hamstring | Emmanuel Moseley (Hamstring) is questionable this week. | Jan 1 |
| 49ers | Jalen Hurd | WR | Out | Placed on IR. | Jalen Hurd (Knee) is out this week. | Dec 3 |
| 49ers | Dre Greenlaw | OLB | Out | Undisclosed | Dre Greenlaw (Undisclosed) is out this week. | Jan 1 |
| 49ers | Deebo Samuel | WR | Out | Hamstring | Deebo Samuel (Hamstring) is out this week. | Jan 1 |
| 49ers | Kevin Givens | DT | Out | Undisclosed | Kevin Givens (Undisclosed) is out this week. | Jan 1 |
| 49ers | Javon Kinlaw | DT | Out | Knee | Javon Kinlaw (Knee) is out this week. | Jan 1 |
| 49ers | Brandon Aiyuk | WR | Out | Ankle | Brandon Aiyuk (Ankle) is out this week. | Jan 1 |
| 49ers | JaMycal Hasty | RB | Out | Placed on IR. | JaMycal Hasty (Collarbone) is out this week. | Dec 3 |
 Seahawks | Damontre Moore | DE | Out | Suspension | Damontre Moore (Suspension) is out this week. | Nov 2 |
| Seahawks | Phillip Dorsett II | WR | Out | Placed on IR. | Phillip Dorsett (Foot) is out this week. | Sep 29 |
| Seahawks | Jarran Reed | DT | Questionable | Oblique | Jarran Reed (Oblique) is questionable this week. | Jan 8 |
| Seahawks | Jonathan Bullard | DE | Out | Placed on Reserve/COVID-19 List. | Jonathan Bullard (Illness) is out this week. | Jan 9 |
| Seahawks | Shaquill Griffin | CB | Questionable | Hamstring | Shaquill Griffin (Hamstring) is questionable this week. | Jan 8 |
| Seahawks | Bo Scarbrough | RB | Out | Placed on IR. | Bo Scarbrough (Undisclosed) is out this week. | Nov 23 |
| Seahawks | Rashaad Penny | RB | Out | Knee | Rashaad Penny (Knee) is out this week. | Jan 9 |
| Seahawks | Stephen Sullivan | TE | Out | Placed on IR | Stephen Sullivan (Undisclosed) is out this week. | Nov 23 |
 Buccaneers | Andrew Adams | SS | Questionable | Undisclosed | Andrew Adams (Undisclosed) is questionable this week. | Jan 15 |
| Buccaneers | O.J. Howard | TE | Out for season | Achilles | OJ Howard (Achilles) is out for the season. | Oct 6 |
| Buccaneers | Jeremiah Ledbetter | DT | Out | Calf | Jeremiah Ledbetter (Calf) is out this week. | Jan 1 |
| Buccaneers | Vita Vea | NT | Out | Placed on Reserve/COVID-19 List. | Vita Vea (Illness) is out this week. | Nov 28 |
| Buccaneers | Alex Cappa | G | Out | Placed on IR. | Alexander Cappa (Ankle) is out this week. | Jan 15 |
| Buccaneers | Jordan Whitehead | SS | Questionable | Knee | Jordan Whitehead (Knee) is questionable this week. | Jan 15 |
| Buccaneers | Devin White | ILB | Out | Placed on Reserve/COVID-19 List. | Devin White (Illness) is out this week. | Jan 1 |
 Titans | Taylor Lewan | T | Out for season | Knee | Taylor Lewan (Knee) is out for the season. | Oct 19 |
| Titans | Adam Humphries | WR | Out | Placed on IR. | Adam Humphries (Concussion) is out this week. | Dec 8 |
| Titans | Chris Milton | CB | Out | Placed on IR. | Chris Milton (Knee) is out this week. | Dec 25 |
| Titans | Aaron Brewer | C | Out | Placed on Reserve/COVID-19 List. | Aaron Brewer (Illness) is out this week. | Jan 7 |
 Football Team | Alex Smith | QB | Out | Calf | Alex Smith (Calf) is out this week. | Jan 9 |
| Football Team | Deshazor Everett | SS | Out | Placed on IR. | Deshazor Everett (Chest) is out this week. | Dec 17 |
| Football Team | Thomas Davis Sr. | OLB | Out | Knee | Thomas Davis (Knee) is out this week. | Jan 7 |
| Football Team | Kevin Pierre-Louis | OLB | Questionable | Ankle | Kevin Pierre-Louis (Ankle) is questionable this week. | Dec 25 |
| Football Team | Matt Ioannidis | DT | Out | Placed on IR. | Matt Ioannidis (Biceps) is out this week. | Dec 25 |
| Football Team | Temarrick Hemingway | TE | Out for season | Wrist | Temarrick Hemingway (Wrist) is out for the season. | Dec 9 |
| Football Team | Kyle Allen | QB | Out for season | Ankle | Kyle Allen (Ankle) is out for the season. | Nov 10 |
| Football Team | Geron Christian | T | Out | Placed on IR. | Geron Christian (Knee) is out this week. | Nov 19 |
| Football Team | Bryce Love | RB | Out | Placed on IR. | Bryce Love (Knee) is out this week. | Oct 2 |
| Football Team | Saahdiq Charles | T | Out for season | Knee | Saahdiq Charles (Knee) is out for the season. | Nov 16 |