 Celtics | Romeo Langford | G-F | Out for season | Right wrist surgery | Romeo Langford underwent wrist surgery; to miss rest of season. | Sep 2 |
 Nets | Kevin Durant | F | Out for season | Right Achilles surgery | Durant: "My season is over. I don't plan on playing at all." | Jun 6 |
| Nets | Michael Beasley | F | Suspended | Five-game suspension | Beasley is suspended with suspension | Jul 4 |
| Nets | Nicolas Claxton | F-C | Out for season | Left shoulder surgery | Nic Claxton underwent season-ending shoulder surgery. | Jun 3 |
 Bulls | Kris Dunn | G | Out for season | Sprained right MCL | Kris Dunn to miss rest of season. | Mar 2 |
| Bulls | Luke Kornet | F-C | Out indefinitely | Sprained left ankle, fractured left foot | Luke Kornet to miss 6-8 weeks. | Feb 4 |
| Bulls | Chandler Hutchison | F-G | Out for season | Right shoulder surgery | Chandler Hutchison to undergo season-ending shoulder surgery. | Mar 3 |
| Bulls | Max Strus | G-F | Out for season | Torn left ACL, bone bruise | Strus is out for season with knee | Dec 2 |
 Cavaliers | Dylan Windler | G-F | Out for season | Left tibial stress reaction | Dylan Windler to miss rest of season. | Jan 1 |
 Mavericks | Courtney Lee | G | Out indefinitely | Calf surgery | Courtney Lee underwent calf surgery. | Jun 1 |
| Mavericks | Kristaps Porzingis | F-C | Out indefinitely | Torn right meniscus | Kristaps Porzingis diagnosed with torn meniscus. | Aug 5 |
| Mavericks | Dwight Powell | F-C | Out for season | Ruptured right Achilles tendon | Dwight Powell underwent season-ending Achilles surgery. | Jan 2 |
| Mavericks | Willie Cauley-Stein Jr. | C | Out for season | Personal | Willie Cauley-Stein to sit out the Orlando restart. | Jun 4 |
| Mavericks | Jalen Brunson | G | Out for season | Right shoulder surgery | Jalen Brunson undergoes shoulder surgery. | Mar 5 |
 Nuggets | Will Barton | F | Out indefinitely | Sore right knee | Will Barton to leave Orlando bubble. | Aug 3 |
| Nuggets | Vlatko Cancar | F | Out indefinitely | Fractured left foot | Cancar is injured with foot | Jul 5 |
 Pistons | Blake Griffin | F | Out indefinitely | Left knee surgery | Blake Griffin underwent knee surgery. | Jan 2 |
| Pistons | Luke Kennard | G | Out indefinitely | Bilateral knee tendinitis | Kennard is injured with knee | Mar 0 |
| Pistons | Justin Patton | C | Out indefinitely | Fractured right pinky | Patton is injured with finger | Sep 3 |
 Warriors | Klay Thompson | G | Out for season | Torn left ACL | Thompson is out for season with knee | Feb 5 |
 Rockets | Thabo Sefolosha | F-G | Out for season | Personal | Thabo Sefolosha to sit out the Orlando restart. | Jul 3 |
 Pacers | Jeremy Lamb | G-F | Out for season | Torn left ACL, torn meniscus, fractured lateral femoral condylar | Lamb is out for season with knee | Mar 0 |
| Pacers | Domantas Sabonis | F-C | Out indefinitely | Left foot plantar fasciitis | Domantas Sabonis to leave Orlando bubble with significant foot injury. | Jul 5 |
 Lakers | Avery Bradley Jr. | G | Out for season | Personal | Avery Bradley to sit out the Orlando restart. | Jun 3 |
 Grizzlies | Justise Winslow | F-G | Out for season | Hip | Justise Winslow to miss rest of season. | Jul 2 |
| Grizzlies | Jaren Jackson Jr. | F-C | Out for season | Torn left meniscus | Jaren Jackson Jr. to miss rest of season with torn meniscus. | Aug 2 |
 Heat | Gabe Vincent | G | Questionable | Sore right knee | Vincent is questionable with knee | Sep 2 |
| Heat | Chris Silva | F | Questionable | Left pubic bone stress fracture | Silva is questionable with pelvis | Sep 2 |
 Timberwolves | Karl-Anthony Towns Jr. | C-F | Out indefinitely | Fractured left wrist | Karl-Anthony Towns out at least 2 more weeks. | Mar 5 |
 Pelicans | Darius Miller | F | Out indefinitely | Ruptured right Achilles | Miller is injured with achilles | Mar 0 |
 Magic | Al-Farouq Aminu | F | Out indefinitely | Right knee surgery | Aminu is injured with knee | Mar 0 |
| Magic | Jonathan Isaac | F | Out for season | Torn left ACL | Jonathan Isaac to miss 2020-2021 season. | Aug 1 |
| Magic | Mo Bamba | C | Out for season | Illness | Mo Bamba leaves Orlando bubble; to miss rest of season. | Aug 5 |
 76ers | Ben Simmons | G-F | Out indefinitely | Left knee surgery | Ben Simmons to undergo knee surgery. | Aug 6 |
 Trail Blazers | Rodney Hood | G-F | Out indefinitely | Torn left Achilles | Rodney Hood diagnosed with torn Achilles. | Dec 6 |
| Trail Blazers | Damian Lillard Sr. | G | Out indefinitely | Sprained right knee | Damian Lillard to leave Orlando bubble. | Aug 4 |
| Trail Blazers | Zach Collins | F-C | Out for season | Left ankle surgery | Zach Collins to undergo season-ending ankle surgery. | Aug 5 |
 Kings | Marvin Bagley III | F | Out for season | Sprained right foot | Marvin Bagley to be held out of Orlando restart. | Jul 3 |
 Spurs | Trey Lyles | F | Out for season | Appendicitis | Trey Lyles to miss the Orlando restart. | Jul 3 |
| Spurs | LaMarcus Aldridge | C-F | Out for season | Right shoulder surgery | LaMarcus Aldridge underwent season-ending shoulder surgery. | Jun 1 |
 Raptors | Patrick McCaw | G-F | Out indefinitely | Sore left knee | Patrick McCaw to leave Orlando bubble. | Aug 5 |
| Raptors | Oshae Brissett | F-G | Out indefinitely | Right knee procedure | Brissett is injured with knee | Aug 2 |
 Jazz | Bojan Bogdanovic | F | Out for season | Right wrist surgery | Bojan Bogdanovic to undergo season-ending wrist surgery. | May 1 |
 Wizards | John Wall Jr. | G | Out indefinitely | Ruptured left Achilles | Wall is injured with achilles | Oct 2 |
| Wizards | Bradley Beal | G | Out for season | Right rotator cuff | Bradley Beal to sit out the Orlando restart. | Jul 2 |
| Wizards | Davis Bertans | F | Out for season | Personal | Davis Bertans to sit out the Orlando restart. | Jun 1 |