Louisville vs. Pittsburgh Odds & Betting Predictions - September 27, 2025

Louisville at Pittsburgh

4:00 pm

Stream Live on SiriusXM - Free 3 Month Offer

Louisville Cardinals

@

Pittsburgh Panthers

MatchupOpenSpreadTotalMoneyline
Louisville 2-0	N/A	N/A	N/A
Pittsburgh 2-0	N/A	N/A	N/A

location pin

Saturday 4:00 p.m.

September 27, 2025

Acrisure StadiumPittsburgh

No props found

NCAAF Public Betting

Pittsburgh are 2-0 in their last 5 games.
Pittsburgh are 2-0 in their last 5 games against the spread
The totals have gone OVER in 2 of Pittsburgh' last 2 games
The totals have gone OVER in 2 of Pittsburgh' 2 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Pittsburgh	2-0	2-0	N/A	1-0	N/A
Louisville	0-2	0-2	N/A	0-2	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Pittsburgh	2-0	2-0	N/A	1-0	N/A
Louisville	1-1	1-1	N/A	1-1	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Pittsburgh	2-0	N/A	N/A	1-0	N/A
Louisville	2-0	N/A	N/A	2-0	N/A

date	opponent	score	spread	over/under	moneyline
Sep 6th	CMU	W 45-17	-21.5 W	O 48	PITT -2000
Aug 30th	DUQ	W 61-9	-40.5 W	O 58.5	-
Dec 26th	@TOL	L 46-48	-6.5 L	O 48.5	TOL -238
Nov 30th	@BC	L 23-34	+3.5 L	O 50.5	BC +140
Nov 23rd	@LOU	L 9-37	+7.5 L	U 57.5	LOU +217

Total

Passing

464

YDS

642

38/60

Comps/Atts

47/70

7.73

YPA

9.17

3/3

TDs/INTs

9/2

3/18

Sacks/Yards

2/10

Rushing

342

Rush Yards

282

60

Attempts

53

5.7

YPC

5.32

5

TDs

4

Turnovers

Fumbles Lost

3

Interceptions

2

Efficiency

5/6 83.3%

Redzone

11/12 91.7%

11/23 0%

3rd Down

11/23 0%

1/2 0%

4th Down

2/4 0%

First Downs

39

Total

43

19

Pass

24

16

Rush

13

4

Penalty

6

Misc

/

Penalties/Yards

/

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Louisville 2-0	N/A	N/A
Pittsburgh 2-0	N/A	N/A