| Akron | Kato Nelson | QB | Questionable | Undisclosed | Nelson is questionable with undisclosed | Oct 13 |
| Alabama | Christopher Allen | LB | Out for season | Foot | Allen is out for season with foot | Sep 9 |
| Alabama | Drew Sanders | LB | Out | Hand | Sanders is out with hand | Oct 14 |
| Alabama | Jase McClellan | RB | Out for season | Undisclosed | McClellan is out for season with undisclosed | Oct 4 |
| App State | Camerun Peoples | RB | Questionable | Undisclosed | Peoples is questionable with undisclosed | Oct 13 |
| Arizona St | Johnny Wilson | WR | Out | Hamstring | Wilson is out with hamstring | Oct 17 |
| Arizona | Rhett Rodriguez | QB | Out | Chest | Rodriguez is out with chest | Sep 28 |
| Arizona | Grant Gunnell | QB | Out | Leg | Gunnell is out with leg | Oct 15 |
| Army | Christian Anderson | QB | Out | Shoulder | Anderson is out with shoulder | Oct 16 |
| Baylor | Charlie Brewer | QB | Out for season | Left Team | Brewer is out for season with left team | Sep 21 |
| Baylor | John Lovett | RB | Questionable | Undisclosed | Lovett is questionable with undisclosed | Oct 14 |
| Boise State | CT Thomas | WR | Out | Undisclosed | Thomas is out with undisclosed | Oct 9 |
| Boise State | Roman Kafentzis | DB | Out for season | Achilles | Kafentzis is out for season with achilles | Sep 17 |
| Boise State | George Holani | RB | Out | Lower Body | Holani is out with lower body | Oct 9 |
| Boston Col | Aaron Boumerhi | K | Out for season | Hip | Boumerhi is out for season with hip | Sep 14 |
| Boston Col | Phil Jurkovec | QB | Out | Hand | Jurkovec is out with hand | Sep 14 |
| Buffalo | Kevin Marks | RB | Out | Undisclosed | Marks is out with undisclosed | Oct 16 |
| Buffalo | Jovany Ruiz | WR | Out | Knee | Ruiz is out with knee | Oct 16 |
| California | DeCarlos Brooks | RB | Out | Lower Body | Brooks is out with lower body | Sep 30 |
| California | Kuony Deng | LB | Out | Lower Body | Deng is out with lower body | Oct 6 |
| California | Stanley McKenzie | NT | Out for season | Leg | McKenzie is out for season with leg | Oct 6 |
| C. Michigan | Drayton Law | WR | Out for season | Undisclosed | Law is out for season with undisclosed | Sep 8 |
| C. Michigan | JaCorey Sullivan | WR | Out | Undisclosed | Sullivan is out with undisclosed | Oct 9 |
| C. Michigan | Troy Brown | LB | Out | Undisclosed | Brown is out with undisclosed | Oct 13 |
| Clemson | Braden Galloway | TE | Out | Concussion | Galloway is out with concussion | Oct 15 |
| Clemson | Lyn-J Dixon | RB | Out | Left Team | Dixon is out with left team | Sep 21 |
| Clemson | Tayquon Johnson | DT | Out for season | Pectoral | Johnson is out for season with pectoral | Sep 18 |
| Clemson | Tyler Davis | DT | Out | Biceps | Davis is out with biceps | Sep 21 |
| Clemson | Lannden Zanders | SAF | Out for season | Undisclosed | Zanders is out for season with undisclosed | Sep 8 |
| Clemson | John Williams | OL | Out for season | Undisclosed | Williams is out for season with undisclosed | Sep 8 |
| Coastal Car | Massimo Biscardi | K | Probable | Lower Body | Biscardi is probable with lower body | Oct 4 |
| Colorado | Tyler Lytle | QB | Out | Undisclosed | Lytle is out with undisclosed | Sep 11 |
| Colorado St | James Mitchell | DL | Out for season | Knee | Mitchell is out for season with knee | Sep 13 |
| UConn | Cameron Ross | WR | Questionable | Undisclosed | Ross is questionable with undisclosed | Sep 16 |
| Duke | Matt Smith | TE | Out for season | Knee | Smith is out for season with knee | Sep 8 |
| E. Carolina | Davondre Robinson | DB | Questionable | Biceps | Robinson is questionable with biceps | Sep 18 |
| Florida | Ventrell Miller | LB | Out for season | Biceps | Miller is out for season with biceps | Sep 16 |
| Florida St | Dennis Briggs Jr. | DE | Out for season | Undisclosed | Briggs is out for season with undisclosed | Oct 7 |
| Florida St | D.J. Matthews | WR | Out for season | Knee | Matthews is out for season with knee | Sep 28 |
| Georgia | Julian Rochester | DL | Out | Knee | Rochester is out with knee | Sep 24 |
| Georgia | JT Daniels | QB | Questionable | Back | Daniels is questionable with back | Oct 16 |
| Georgia | Tommy Bush | WR | Out for season | Leg | Bush is out for season with leg | Oct 15 |
| Georgia | George Pickens | WR | Out | Knee | Pickens is out with knee | Sep 8 |
| Georgia | Major Burns | DB | Out | Undisclosed | Burns is out with undisclosed | Oct 6 |
| Georgia | Tate Ratledge | OL | Out for season | Foot | Ratledge is out for season with foot | Sep 8 |
| GA Southern | Shai Werts | QB | Questionable | Lower Body | Werts is questionable with lower body | Sep 28 |
| GA Southern | Derrick Canteen | CB | Out for season | Undisclosed | Canteen is out for season with undisclosed | Sep 17 |
| GA Southern | Khaleb Hood | WR | Questionable | Arm | Hood is questionable with arm | Oct 15 |
| Illinois | Ra'Von Bonner | RB | Out | Undisclosed | Bonner is out with undisclosed | Sep 25 |
| Illinois | Jordyn Slaughter | OL | Out for season | Ankle | Slaughter is out for season with ankle | Sep 8 |
| Illinois | Chase Brown | RB | Questionable | Undisclosed | Brown is questionable with undisclosed | Sep 28 |
| Indiana | Michael Penix Jr. | QB | Out | Shoulder | Penix is out with shoulder | Oct 4 |
| Indiana | David Ellis | WR | Out for season | Ankle | Ellis is out for season with ankle | Oct 11 |
| Indiana | Christopher Keys | DB | Out for season | Knee | Keys is out for season with knee | Sep 20 |
| Iowa | Riley Moss | DB | Out | Knee | Moss is out with knee | Oct 13 |
| Kansas | Daniel Hishaw Jr. | RB | Out for season | Undisclosed | Hishaw is out for season with undisclosed | Sep 8 |
| K State | Khalid Duke | DE | Out for season | Lower Body | Duke is out for season with lower body | Sep 21 |
| K State | Will Jones II | DB | Out for season | Knee | Jones is out for season with knee | Sep 8 |
| Kentucky | Terry Wilson | QB | Out | Elbow | Wilson is out with elbow | Oct 16 |
| Kentucky | Josh Ali | WR | Out | Undisclosed | Ali is out with undisclosed | Oct 6 |
| Kentucky | Marquan McCall | NT | Out | Leg | McCall is out with leg | Oct 6 |
| LSU | Glen Logan | DE | Out | Undisclosed | Logan is out with undisclosed | Sep 11 |
| LSU | Chasen Hines | OG | Out | Undisclosed | Hines is out with undisclosed | Sep 11 |
| LSU | Derek Stingley Jr. | CB | Out | Foot | Stingley is out with foot | Oct 6 |
| LSU | John Emery Jr. | RB | Out for season | Academics | Emery is out for season with academics | Sep 14 |
| LSU | Eli Ricks | CB | Out for season | Undisclosed | Ricks is out for season with undisclosed | Oct 13 |
| LSU | Ali Gaye | DL | Out for season | Undisclosed | Gaye is out for season with undisclosed | Oct 15 |
| LSU | Arik Gilbert | TE | Out | Personal | Gilbert is out with personal | Sep 14 |
| LSU | Kayshon Boutte | WR | Out for season | Ankle | Boutte is out for season with ankle | Oct 12 |
| Lamar | Jaylon Jackson | RB | Out | Undisclosed | Jackson is out with undisclosed | Sep 29 |
| Liberty | Demario Douglas | WR | Questionable | Undisclosed | Douglas is questionable with undisclosed | Oct 16 |
| LA Tech | Luke Anthony | QB | Out | Ankle | Anthony is out with ankle | Oct 16 |
| LA-Lafayette | Andre Landry | DL | Out for season | Undisclosed | Landry is out for season with undisclosed | Sep 8 |
| LA-Lafayette | Kenneth Almendares | K | Out for season | Undisclosed | Almendares is out for season with undisclosed | Sep 30 |
| Marshall | Talik Keaton | WR | Out | Hand | Keaton is out with hand | Oct 15 |
| Maryland | Dontay Demus Jr. | WR | Out for season | Leg | Demus is out for season with leg | Oct 5 |
| Maryland | Fa'Najae Gotay | LB | Out | Upper Body | Gotay is out with upper body | Sep 8 |
| UMASS | Josiah Johnson | ATH | Out | Undisclosed | Johnson is out with undisclosed | Oct 3 |
| UMASS | Zack Magdis | LB | Out for season | Undisclosed | Magdis is out for season with undisclosed | Sep 22 |
| Memphis | Gabriel Rogers | DB | Out | Undisclosed | Rogers is out with undisclosed | Oct 14 |
| Memphis | Rodrigues Clark | RB | Out | Undisclosed | Clark is out with undisclosed | Oct 14 |
| Miami (FL) | D'Eriq King | QB | Out for season | Shoulder | King is out for season with shoulder | Oct 11 |
| Miami (FL) | Mike Harley | WR | Questionable | Upper Body | Harley is questionable with upper body | Sep 7 |
| Miami (FL) | Cam'Ron Harris | RB | Out | Knee | Harris is out with knee | Oct 16 |
| Miami (FL) | Jalen Rivers | OL | Out for season | Knee | Rivers is out for season with knee | Sep 22 |
| Miami (FL) | Donald Chaney Jr. | RB | Out for season | Knee | Chaney is out for season with knee | Sep 14 |
| Miami (OH) | Jaylon Bester | RB | Questionable | Undisclosed | Bester is questionable with undisclosed | Oct 12 |
| Miami (OH) | Brett Gabbert | QB | Out | Undisclosed | Gabbert is out with undisclosed | Oct 16 |
| Michigan St | Drew Beesley | DE | Out | Lower Body | Beesley is out with lower body | Oct 16 |
| Michigan St | Elijah Collins | RB | Out | Leg | Collins is out with leg | Oct 16 |
| Michigan | Ronnie Bell | WR | Out for season | Knee | Bell is out for season with knee | Sep 8 |
| Michigan | Roman Wilson | WR | Out | Wrist | Wilson is out with wrist | Oct 9 |
| Middle Tenn | Chaton Mobley | RB | Out | Undisclosed | Mobley is out with undisclosed | Sep 25 |
| Minnesota | Mohamed Ibrahim | RB | Out for season | Leg | Ibrahim is out for season with leg | Sep 8 |
| Minnesota | Mike Brown-Stephens | WR | Questionable | Head | Brown-Stephens is questionable with head | Sep 8 |
| Minnesota | Treyson Potts | RB | Out for season | Undisclosed | Potts is out for season with undisclosed | Oct 11 |
| Missouri | Barrett Banister | WR | Out | Undisclosed | Banister is out with undisclosed | Oct 16 |
| Missouri | Dominic Gicinto | WR | Out for season | Arm | Gicinto is out for season with arm | Sep 8 |
| Nebraska | Rahmir Johnson | RB | Questionable | Undisclosed | Johnson is questionable with undisclosed | Oct 16 |
| Nevada | Elijah Cooks | WR | Out for season | Foot | Cooks is out for season with foot | Sep 28 |
| NC State | Calvin 'C.J.' Hart Jr. | LB | Out for season | Knee | Hart is out for season with knee | Sep 8 |
| NC State | Payton Wilson | LB | Out for season | Shoulder | Wilson is out for season with shoulder | Sep 14 |
| UNC | Beau Corrales | WR | Out | Lower Body | Corrales is out with lower body | Sep 8 |
| UNC | Ladaeson DeAndre Hollins | DB | Out for season | Lower Body | Hollins is out for season with lower body | Sep 15 |
| UNC | Jalen Brooks | LB | Out | Undisclosed | Brooks is out with undisclosed | Oct 16 |
| North Texas | Deonte Simpson | WR | Out for season | Dismissed | Simpson is out for season with dismissed | Oct 13 |
| N. Illinois | Harrison Waylee | RB | Out | Arm | Waylee is out with arm | Oct 16 |
| N. Illinois | Devin Lafayette | SAF | Out | Leg | Lafayette is out with leg | Sep 8 |
| Northwestern | Bryce Kirtz | WR | Out | Undisclosed | Kirtz is out with undisclosed | Oct 16 |
| Notre Dame | Joe Wilkins | WR | Out for season | Knee | Wilkins is out for season with knee | Oct 7 |
| Ohio State | Josh Proctor | SAF | Out for season | Leg | Proctor is out for season with leg | Sep 14 |
| Ohio State | Jake Seibert | K | Out | Undisclosed | Seibert is out with undisclosed | Oct 9 |
| Ohio State | Mookie Cooper | WR | Questionable | Foot | Cooper is questionable with foot | Oct 14 |
| Oklahoma | Theo Wease | WR | Out | Leg | Wease is out with leg | Sep 12 |
| OK State | Josh Sills | OL | Questionable | Undisclosed | Sills is questionable with undisclosed | Sep 8 |
| OK State | LD Brown | RB | Out | Undisclosed | Brown is out with undisclosed | Sep 25 |
| OK State | Braydon Johnson | WR | Out for season | Undisclosed | Johnson is out for season with undisclosed | Sep 30 |
| OK State | Trace Ford | DE | Out for season | Knee | Ford is out for season with knee | Sep 10 |
| Ole Miss | Braylon Sanders | WR | Questionable | Lower Body | Sanders is questionable with lower body | Oct 17 |
| Oregon | Cam McCormick | TE | Out for season | Leg | McCormick is out for season with leg | Sep 14 |
| Oregon | Cyrus Habibi-Likio | RB | Out | Undisclosed | Habibi-Likio is out with undisclosed | Oct 17 |
| Oregon | CJ Verdell | RB | Questionable | Undisclosed | Verdell is questionable with undisclosed | Oct 3 |
| Oregon | Tyler Shough | QB | Out | Upper Body | Shough is out with upper body | Sep 25 |
| Oregon | Dru Mathis | LB | Out | Knee | Mathis is out with knee | Sep 8 |
| Penn State | Sean Clifford | QB | Questionable | Undisclosed | Clifford is questionable with undisclosed | Oct 14 |
| Penn State | PJ Mustipher | DT | Out for season | Knee | Mustipher is out for season with knee | Oct 14 |
| Penn State | Adisa Isaac | DE | Out for season | Undisclosed | Isaac is out for season with undisclosed | Sep 11 |
| Purdue | Zander Horvath | RB | Out | Leg | Horvath is out with leg | Sep 14 |
| Purdue | Cory Trice | SAF | Out for season | Knee | Trice is out for season with knee | Oct 15 |
| Purdue | Jack Cravaack | TE | Out for season | Knee | Cravaack is out for season with knee | Sep 20 |
| Purdue | Mershawn Rice | WR | Out for season | Foot | Rice is out for season with foot | Oct 14 |
| Purdue | Geovonte' Howard | CB | Questionable | Ankle | Howard is questionable with ankle | Sep 12 |
| Purdue | Abdur-Rahmaan Yaseen | WR | Out for season | Undisclosed | Yaseen is out for season with undisclosed | Oct 14 |
| Rice | Wiley Green | QB | Out | Undisclosed | Green is out with undisclosed | Sep 21 |
| Rutgers | Aron Cruickshank | WR | Questionable | Undisclosed | Cruickshank is questionable with undisclosed | Oct 12 |
| Rutgers | Kay'Ron Adams | RB | Out for season | Ankle | Adams is out for season with ankle | Oct 5 |
| San Diego St | Kobe Smith | WR | Out | Undisclosed | Smith is out with undisclosed | Oct 14 |
| San Jose St | Nick Starkel | QB | Out | Arm | Starkel is out with arm | Oct 3 |
| S. Alabama | Shawn Jennings | LB | Out | Undisclosed | Jennings is out with undisclosed | Oct 15 |
| S. Alabama | Patrick Rosette | SAF | Out for season | Knee | Rosette is out for season with knee | Sep 8 |
| S. Alabama | Caullin Lacy | WR | Questionable | Undisclosed | Lacy is questionable with undisclosed | Oct 15 |
| S. Carolina | Randrecous Davis | WR | Out for season | Personal | Davis is out for season with personal | Sep 24 |
| S. Carolina | Juju McDowell | | Out | Undisclosed | McDowell is out with undisclosed | Oct 16 |
| S. Florida | Latrell Williams | WR | Out for season | Knee | Williams is out for season with knee | Sep 21 |
| S. Florida | Jordan McCloud | QB | Out for season | Leg | McCloud is out for season with leg | Oct 16 |
| S. Florida | Christian Helms | WR | Out | Foot | Helms is out with foot | Sep 8 |
| SMU | TJ McDaniel | RB | Out | Leg | McDaniel is out with leg | Sep 18 |
| Southern Miss | Darius Maberry | RB | Out for season | Undisclosed | Maberry is out for season with undisclosed | Sep 16 |
| Stanford | Michael Wilson | WR | Out | Foot | Wilson is out with foot | Sep 8 |
| Stanford | Brycen Tremayne | WR | Out | Knee | Tremayne is out with knee | Oct 6 |
| Stanford | E.J. Smith | RB | Out | Undisclosed | Smith is out with undisclosed | Oct 5 |
| Stanford | John Humphreys | WR | Out | Undisclosed | Humphreys is out with undisclosed | Oct 13 |
| Syracuse | Taj Harris | WR | Out for season | Left Team | Harris is out for season with left team | Oct 15 |
| TCU | Atanza Vongor | SAF | Out for season | Undisclosed | Vongor is out for season with undisclosed | Oct 6 |
| TCU | Max Duggan | QB | Questionable | Undisclosed | Duggan is questionable with undisclosed | Oct 12 |
| TCU | Quentin Johnston | WR | Out | Knee | Johnston is out with knee | Oct 9 |
| TCU | Zach Evans | RB | Out | Undisclosed | Evans is out with undisclosed | Oct 16 |
| Temple | DaeSean Winston | SAF | Out | Undisclosed | Winston is out with undisclosed | Sep 11 |
| Temple | David Martin-Robinson | TE | Out | Shoulder | Martin-Robinson is out with shoulder | Sep 8 |
| Temple | Re'Mahn Davis | RB | Out for season | Foot | Davis is out for season with foot | Sep 21 |
| Tennessee | J.T. Shrout | QB | Out for season | Knee | Shrout is out for season with knee | Sep 8 |
| Texas A&M | Myles Jones | DB | Out for season | Foot | Jones is out for season with foot | Oct 7 |
| Texas A&M | Caleb Chapman | WR | Out | Undisclosed | Chapman is out with undisclosed | Oct 16 |
| Texas A&M | Haynes King | QB | Out | Ankle | King is out with ankle | Sep 14 |
| Texas | Denzel Okafor | OL | Out for season | Undisclosed | Okafor is out for season with undisclosed | Oct 7 |
| Texas | Samuel Cosmi | OL | Out | Ankle | Samuel Cosmi (ankle) is out this week. | Oct 17 |
| Texas | Brayden Liebrock | TE | Out for season | Shoulder | Liebrock is out for season with shoulder | Sep 8 |
| Texas | Jordan Whittington | WR | Out | Collarbone | Whittington is out with collarbone | Oct 14 |
| Texas | Troy Omeire | WR | Out for season | Knee | Omeire is out for season with knee | Sep 30 |
| Texas Tech | Ja'Lynn Polk | WR | Out | Chest | Polk is out with chest | Sep 8 |
| Texas Tech | Tahj Brooks | RB | Out | Leg | Brooks is out with leg | Oct 16 |
| Troy | B.J. Smith | RB | Questionable | Undisclosed | Smith is questionable with undisclosed | Oct 14 |
| Tulsa | Josh Stewart | WR | Out for season | Undisclosed | Stewart is out for season with undisclosed | Sep 8 |
| UCF | Jaylon Robinson | WR | Out | Undisclosed | Robinson is out with undisclosed | Oct 9 |
| UCF | Dillon Gabriel | QB | Out | Shoulder | Gabriel is out with shoulder | Sep 18 |
| UCLA | Dorian Thompson-Robinson | QB | Probable | Arm | Thompson-Robinson is probable with arm | Sep 28 |
| UNLV | Giovanni Fauolo Sr. | TE | Out for season | Knee | Fauolo is out for season with knee | Oct 12 |
| UNLV | Tyleek Collins | WR | Out | Undisclosed | Collins is out with undisclosed | Oct 2 |
| UNLV | Doug Brumfield | QB | Questionable | Knee | Brumfield is questionable with knee | Oct 13 |
| USC | Kyle Ford | WR | Probable | Knee | Ford is probable with knee | Oct 2 |
| USC | Drake Jackson | OLB | Questionable | Leg | Jackson is questionable with leg | Oct 13 |
| UTEP | Walter Dawn Jr. | WR | Out for season | Achilles | Dawn is out for season with achilles | Sep 23 |
| UTSA | Kevin Davis | OL | Out | Undisclosed | Davis is out with undisclosed | Oct 7 |
| UTSA | Brenden Brady | RB | Questionable | Undisclosed | Brady is questionable with undisclosed | Oct 7 |
| Utah | JaTravis Broughton | DB | Out for season | Undisclosed | Broughton is out for season with undisclosed | Sep 22 |
| Vanderbilt | Ken Seals | QB | Out | Finger | Seals is out with finger | Oct 16 |
| Virginia | Nathaniel Beal III | WR | Out for season | Knee | Beal is out for season with knee | Sep 8 |
| Virginia | Mike Hollins | RB | Out | Undisclosed | Hollins is out with undisclosed | Oct 16 |
| VA Tech | Hendon Hooker | QB | Questionable | Leg | Hooker is questionable with leg | Oct 17 |
| VA Tech | Keshawn King | RB | Probable | Illness | King is probable with illness | Sep 25 |
| Wake Forest | Miles Fox | DL | Out | Undisclosed | Fox is out with undisclosed | Sep 25 |
| Washington | Terrell Bynum | WR | Questionable | Undisclosed | Bynum is questionable with undisclosed | Sep 10 |
| Washington | Zion Tupuola-Fetui | OLB | Out | Achilles | Tupuola-Fetui is out with achilles | Oct 6 |
| West Virginia | Tykee Smith | SAF | Out for season | Knee | Smith is out for season with knee | Oct 15 |
| W. Kentucky | Joshua Simon | TE | Out for season | Knee | Simon is out for season with knee | Sep 11 |
| Wisconsin | Isaac Guerendo | RB | Out | Ankle | Guerendo is out with ankle | Oct 16 |
| Wisconsin | Jalen Berger | RB | Out for season | Dismissed | Berger is out for season with dismissed | Oct 12 |