Orioles vs. Guardians Odds & Betting Predictions - July 22, 2025

Orioles at Guardians

10:40 pm • CLEG

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Baltimore Orioles

@

Cleveland Guardians

pitcher		team	era	w-l
J.Cantillo			4.17	1-0
B.Young			7.52	0-4

MatchupOpenSpreadTotalMoneyline
Orioles 44-54	+1.5	+1.5-182	o8.5-109	+118
Guardians 48-50	u8	-1.5+149	u8.5-111	-140

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Tuesday 10:40 p.m.

July 22, 2025

Progressive FieldCleveland

CLE -135

1.35u

No props found

MLB Public Betting

Guardians are 4-1 in their last 5 games.
Guardians are 3-2 in their last 5 games against the spread
Guardians are 29-23 in their road games against the spread
The totals have gone OVER in 4 of Guardians' last 5 games
The totals have gone OVER in 22 of Guardians' 46 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Guardians	50-48	21-25	29-23	18-19	32-28
Orioles	42-56	18-29	24-27	16-32	24-24

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Guardians	42-52-4	22-23-1	20-29-3	19-18	23-33-4
Orioles	41-54-3	24-21-2	17-33-1	23-23-2	17-30-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Guardians	48-50	22-24	26-26	23-14	25-35
Orioles	44-54	22-25	22-29	21-27	21-27

date	opponent	score	spread	over/under	moneyline
Jul 21st	BAL	W 10-5	-1.5 W	O 8.5	CLE -143
Jul 20th	ATH	W 8-2	+1.5 W	O 7.5	CLE -106
Jul 19th	ATH	L 2-8	-1.5 L	O 9	ATH -134
Jul 18th	ATH	W 8-6	-1.5 W	O 8	CLE -134
Jul 13th	@CWS	W 6-5	-1.5 L	O 8.5	CLE -142

Gabriel Arias
SS
Arias is out with leg
Out
Ben Lively
SP
Lively is out with elbow
Out
Shane Bieber
SP
Bieber is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Albert Suarez
RP
Suarez is out with shoulder
Out
Jorge Mateo
SS
Mateo is out with hamstring
Out
Zach Eflin
SP
Eflin is out with back
Out
Kyle Bradish
SP
Bradish is out with elbow
Out
Grayson Rodriguez
SP
Rodriguez is out with elbow
Out
Tyler Wells
SP
Wells is out with elbow
Out
Adley Rutschman
C
Rutschman is out with oblique
Out
Cade Povich
SP
Povich is out with hip
Out

See more MLB Injuries

PITCHER		W-L	ERA	WHIP	K/9
RB.Young, P		0-4	7.52	1.785	8.54

HITTERS	AVG	OBP	SLG	HR
1J.Holliday, 2B	.258	.307	.416	13
2J.Westburg, DH	.263	.313	.475	10
3G.Henderson, SS	.280	.345	.461	11
4R.Laureano, LF	.276	.340	.498	11
5T.O'Neill, RF	.182	.270	.327	3
6R.Urias, 3B	.244	.294	.368	6
7C.Cowser, CF	.231	.289	.442	8
8C.Mayo, 1B	.195	.250	.293	1
9J.Stallings, C	.115	.148	.154	0

PITCHER		W-L	ERA	WHIP	K/9
LJ.Cantillo, P		1-0	4.17	1.439	11.85

HITTERS	AVG	OBP	SLG	HR
1S.Kwan, LF	.285	.345	.396	6
2A.Martinez, CF	.246	.268	.409	9
3J.Ramirez, 3B	.295	.365	.517	19
4K.Manzardo, DH	.214	.289	.435	15
5C.Santana, 1B	.228	.325	.353	11
6N.Jones, RF	.228	.320	.325	3
7D.Schneemann, 2B	.215	.292	.384	9
8B.Rocchio, SS	.199	.253	.294	1
9B.Naylor, C	.166	.268	.341	9

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MatchupOverUnder
Orioles 44-54	N/A	N/A
Guardians 48-50	N/A	N/A