 Diamondbacks | Christian Walker | IF | Out indefinitely | Strained right oblique | Christian Walker placed on 10-day IL. | Apr 13 |
| Diamondbacks | Ketel Marte | OF | Out indefinitely | Strained right hamstring | Ketel Marte placed on 10-day IL. | Apr 8 |
 Braves | Mike Soroka | P | Out indefinitely | Torn right Achilles tendon | Soroka is injured with leg | Mar 24 |
| Braves | Touki Toussaint | P | Out indefinitely | Strained right shoulder | Toussaint is injured with shoulder | Mar 30 |
 Orioles | Chris Davis | IF | Out indefinitely | Strained lower back | Davis is injured with back | Mar 24 |
| Orioles | Wade LeBlanc | P | Out indefinitely | Left elbow stress reaction | Wade LeBlanc placed on 60-day IL. | Aug 25 |
| Orioles | Austin Hays | OF | Out indefinitely | strained right hamstring | Austin Hays placed on 10-day IL. | Apr 5 |
| Orioles | Stevie Wilkerson | OF | Out indefinitely | Fractured left ring finger | Wilkerson is injured with finger | Jul 21 |
 Cubs | Austin Romine | C | Out indefinitely | Sprained right knee | Romine is injured with knee | Apr 1 |
 White Sox | Billy Hamilton | OF | Out indefinitely | Strained left hamstring | Billy Hamilton placed on 10-day IL. | Apr 8 |
| White Sox | Tim Anderson | IF | Out indefinitely | strained left hamstring | Tim Anderson placed on 10-day IL. | Apr 7 |
| White Sox | Adam Engel | OF | Out indefinitely | Strained right hamstring | Engel is injured with hamstring | Mar 30 |
| White Sox | Eloy Jiménez | OF | Out indefinitely | Ruptured left pectoral tendon | Jimenez is injured with chest | Mar 30 |
 Reds | Sonny Gray | P | Out indefinitely | Strained back muscle | Gray is injured with back | Mar 30 |
| Reds | Michael Lorenzen | P | Out indefinitely | Strained shoulder | Lorenzen is injured with shoulder | Mar 30 |
| Reds | Shogo Akiyama | OF | Out indefinitely | Strained left hamstring | Akiyama is injured with hamstring | Mar 30 |
 Rockies | Ian Desmond | OF | Out for season | Personal | Desmond is out for season with personal | Mar 30 |
| Rockies | Chris Owings | IF | Out indefinitely | Sprained left thumb | Chris Owings placed on 10-day IL. | Apr 10 |
| Rockies | Kyle Freeland | P | Out indefinitely | Hamstring | Freeland is injured with hamstring | Mar 30 |
| Rockies | Peter Lambert | P | Out indefinitely | Tommy John surgery | Lambert is injured with elbow | Mar 30 |
| Rockies | Brendan Rodgers | IF | Out indefinitely | Strained right hamstring | Rodgers is injured with hamstring | Mar 30 |
 Tigers | Miguel Cabrera | IF | Out indefinitely | Strained left biceps | Miguel Cabrera placed on 10-day IL. | Apr 11 |
| Tigers | Julio Teheran | P | Out indefinitely | Strained right shoulder | Julio Teheran placed on 10-day IL. | Apr 10 |
| Tigers | Spencer Turnbull | P | Out | COVID-19 | Turnbull is out with covid protocols | Mar 30 |
 Astros | Justin Verlander | P | Out indefinitely | Tommy John surgery | Verlander is injured with arm | Mar 30 |
| Astros | Framber Valdez | P | Out indefinitely | Fractured left ring finger | Valdez is injured with finger | Mar 30 |
 Royals | Adalberto Mondesi | IF | Out indefinitely | Strained right oblique | Mondesi is injured with oblique | Mar 31 |
 Angels | Max Stassi | C | Questionable | Left thumb irritation | Stassi is questionable with thumb | Apr 13 |
| Angels | Dexter Fowler | OF | Out indefinitely | Torn ACL | Dexter Fowler diagnosed with torn ACL. | Apr 11 |
| Angels | Juan Lagares | OF | Questionable | Tight left calf | Lagares is questionable with calf | Apr 13 |
| Angels | Anthony Rendon | IF | Out indefinitely | Strained left groin | Anthony Rendon placed on 10-day IL. | Apr 13 |
| Angels | Franklin Barreto | IF | Out indefinitely | Elbow inflammation | Barreto is injured with elbow | Mar 30 |
 Dodgers | Mookie Betts | OF | Questionable | Stiff lower back | Betts is questionable with back | Apr 11 |
| Dodgers | Cody Bellinger | OF | Out indefinitely | Left calf contusion | Bellinger is injured with calf | Apr 10 |
 Marlins | Jorge Alfaro | C | Questionable | Tight left hamstring | Alfaro is questionable with hamstring | Apr 13 |
| Marlins | Elieser Hernandez | P | Out indefinitely | Right biceps inflammation | Elieser Hernandez placed on 10-day IL. | Apr 5 |
 Brewers | Kolten Wong | IF | Out indefinitely | Strained left oblique | Kolten Wong to be placed on 10-day IL. | Apr 10 |
| Brewers | Christian Yelich | OF | Questionable | Tight low back | Yelich is questionable with back | Apr 13 |
| Brewers | Tim Lopes | OF | Out indefinitely | Oblique | Lopes is injured with oblique | Mar 30 |
| Brewers | Derek Fisher | OF | Out indefinitely | Strained left hamstring | Fisher is injured with hamstring | Apr 1 |
 Twins | Josh Donaldson | IF | Out | Tight right hamstring | Donaldson is out with hamstring | Apr 13 |
| Twins | Nelson Cruz | DH | Out | non-COVID related illness | Nelson Cruz scratched Tuesday. | Apr 13 |
| Twins | Keon Broxton | OF | Out | One-game suspension | Broxton is out with suspension | Sep 2 |
| Twins | Brent Rooker | OF | Out indefinitely | Strained cervical | Brent Rooker placed on 10-day IL. | Apr 7 |
 Mets | Carlos Carrasco | P | Out indefinitely | Strained hamstring | Carrasco is injured with hamstring | Mar 30 |
| Mets | Noah Syndergaard | P | Out indefinitely | Tommy John surgery | Syndergaard is injured with elbow | Mar 30 |
| Mets | J.D. Davis | IF | Out indefinitely | Left hand contusion | J.D. Davis placed on 10-day IL. | Apr 10 |
 Yankees | Luis Severino | P | Out indefinitely | Tommy John surgery | Severino is injured with elbow | Mar 30 |
| Yankees | Luke Voit | IF | Out indefinitely | Torn left meniscus | Voit is injured with knee | Mar 30 |
| Yankees | Miguel Andújar | IF | Out indefinitely | Right wrist carpal tunnel syndrome | Andujar is injured with wrist | Mar 31 |
 Athletics | Mike Fiers | P | Out indefinitely | Hip inflammation | Fiers is injured with hip | Mar 30 |
| Athletics | Mitch Moreland | IF | Out | Tight hamstring | Moreland is out with hamstring | Apr 13 |
| Athletics | Chad Pinder | IF | Out indefinitely | sprained left knee | Chad Pinder placed on 10-day IL. | Apr 5 |
| Athletics | Matt Olson | IF | Out | Left thumb contusion | Olson is out with thumb | Apr 13 |
 Pirates | Steven Brault | P | Out indefinitely | Strained lat | Brault is injured with back | Mar 30 |
| Pirates | Ke'Bryan Hayes | IF | Out indefinitely | Left wrist discomfort | Ke'Bryan Hayes placed on IL. | Apr 4 |
 Padres | Mike Clevinger | P | Out indefinitely | Tommy John surgery | Clevinger is injured with arm | Mar 30 |
| Padres | Fernando Tatis Jr. | IF | Out indefinitely | Left shoulder subluxation | Fernando Tatis Jr. to be placed on IL. | Apr 7 |
| Padres | Austin Nola | C | Out indefinitely | Fractured middle finger | Nola is injured with finger | Mar 30 |
| Padres | Adrian Morejon | P | Out indefinitely | Strained left forearm | Adrian Morejon placed on 10-day IL. | Apr 13 |
 Giants | Tyler Beede | P | Out indefinitely | Tommy John surgery | Beede is injured with elbow | Mar 30 |
 Mariners | James Paxton | P | Out indefinitely | Tommy John surgery | James Paxton to undergo Tommy John surgery. | Apr 13 |
| Mariners | Kyle Lewis | OF | Out indefinitely | Right knee bone bruise | Lewis is injured with knee | Mar 31 |
| Mariners | Jake Fraley | OF | Out indefinitely | left hamstring strain | Jake Fraley placed on 10-day IL. | Apr 7 |
| Mariners | Shed Long Jr. | IF | Out indefinitely | Lower leg | Long is injured with leg | Mar 30 |
 Cardinals | Dakota Hudson | P | Out indefinitely | Tommy John surgery | Hudson is injured with elbow | Mar 30 |
| Cardinals | Tyler O'Neill | OF | Out indefinitely | Strained right groin | Tyler O'Neill placed on 10-day IL. | Apr 11 |
| Cardinals | Harrison Bader | OF | Out indefinitely | Strained right forearm | Bader is injured with arm | Mar 30 |
| Cardinals | Miles Mikolas | P | Out indefinitely | Sore shoulder | Mikolas is injured with shoulder | Mar 30 |
| Cardinals | Kwang Hyun Kim | P | Out indefinitely | Back | Kim is injured with back | Mar 30 |
 Rays | Kevin Kiermaier | OF | Out indefinitely | left quad strain | Kevin Kiermaier placed on 10-day IL. | Apr 6 |
| Rays | Chris Archer | P | Out indefinitely | Tight right forearm | Chris Archer placed on 10-day IL. | Apr 10 |
| Rays | Ji-Man Choi | IF | Out indefinitely | Right knee surgery | Choi is injured with knee | Mar 31 |
| Rays | Yonny Chirinos | P | Out indefinitely | Strained right elbow | Chirinos is injured with elbow | Mar 30 |
 Rangers | Brock Holt | IF | Out indefinitely | Strained right hamstring | Brock Holt placed on 10-day IL. | Apr 9 |
| Rangers | Khris Davis | OF | Out indefinitely | Strained left quad | Davis is injured with quad | Mar 30 |
| Rangers | Tyson Ross | P | Out for season | Personal | Ross is out for season with personal | Jul 5 |
| Rangers | Willie Calhoun | OF | Out indefinitely | Strained groin | Calhoun is injured with groin | Mar 30 |
| Rangers | Ronald Guzmán | IF | Doubtful | Hamstring injury | Guzman is doubtful with knee | Apr 13 |
 Blue Jays | George Springer | OF | Out indefinitely | Strained left oblique | Springer is injured with oblique | Mar 31 |
| Blue Jays | Teoscar Hernández | OF | Out | Covid-19 list close contact | Teoscar Hernandez placed on COVID-19 list. | Apr 9 |
 Nationals | Jon Lester | P | Out | Undisclosed | Jon Lester placed on IL. | Apr 6 |