 Diamondbacks | Domingo Leyba | IF | Suspended | Suspension | Leyba is suspended with suspension | Jul 2 |
| Diamondbacks | Merrill Kelly | P | Out indefinitely | Right shoulder nerve impingement | Merrill Kelly placed on 10-day IL. | Aug 25 |
| Diamondbacks | Josh Rojas | OF | Out indefinitely | Low back inflammation | Josh Rojas placed on 10-day IL. | Sep 22 |
 Braves | Mike Soroka | P | Out for season | Torn right Achilles tendon | Mike Soroka diagnosed with torn Achilles; to miss rest of season. | Aug 4 |
 Orioles | Chris Davis | IF | Out indefinitely | Left knee patellar tendinitis | Chris Davis placed on 10-day IL. | Sep 14 |
| Orioles | Trey Mancini | OF | Out for season | Colon cancer | Mancini is out for season with abdomen | Jul 2 |
| Orioles | Richie Martin | IF | Out indefinitely | Fractured right wrist | Martin is injured with wrist | Jul 13 |
| Orioles | Anthony Santander | OF | Out for season | Strained right oblique | Santander is out for season with oblique | Sep 12 |
| Orioles | Stevie Wilkerson | OF | Out indefinitely | Fractured left ring finger | Wilkerson is injured with finger | Jul 21 |
 Red Sox | Dustin Pedroia | IF | Out indefinitely | Left knee | Pedroia is injured with knee | Jul 2 |
| Red Sox | Eduardo Rodríguez | P | Out for season | Myocarditis | Eduardo Rodriguez to miss rest of season. | Aug 1 |
| Red Sox | Chris Sale | P | Out for season | Tommy John surgery | Sale is out for season with elbow | Jul 2 |
| Red Sox | Andrew Benintendi | OF | Out for season | Strained right rib cage | Andrew Benintendi to miss rest of season. | Sep 8 |
| Red Sox | Yairo Muñoz | IF | Out indefinitely | Strained lower back | Yairo Munoz placed on 10-day IL. | Sep 19 |
| Red Sox | Colten Brewer | P | Out indefinitely | Strained right finger | Colten Brewer placed on 10-day IL. | Sep 3 |
 White Sox | Adam Eaton | OF | Out indefinitely | Fractured left index finger | Adam Eaton diagnosed with fractured finger. | Sep 17 |
| White Sox | Michael Kopech | P | Out for season | Personal | Kopech is out for season with personal | Jul 13 |
 Indians | Andrés Giménez | IF | Out indefinitely | Tight right oblique | Andres Gimenez placed on 10-day IL. | Sep 26 |
 Rockies | Ian Desmond | OF | Out for season | Personal | Desmond is out for season with personal | Jul 2 |
| Rockies | Nolan Arenado | IF | Out indefinitely | Left AC joint inflammation, left shoulder bone bruise | Nolan Arenado placed on 10-day IL. | Sep 21 |
| Rockies | Jon Gray | P | Out for season | Right shoulder inflammation | Jon Gray to miss rest of season. | Sep 16 |
| Rockies | Peter Lambert | P | Out indefinitely | Tommy John surgery | Lambert is injured with elbow | Jul 23 |
| Rockies | Brendan Rodgers | IF | Out indefinitely | Strained right shoulder capsular | Brendan Rodgers placed on 10-day IL. | Sep 1 |
 Tigers | Jeimer Candelario | IF | Out indefinitely | Strained lower back | Jeimer Candelario placed on 10-day IL. | Sep 25 |
| Tigers | José Ureña | P | Out for season | Fractured right forearm | Jose Urena to miss playoffs with fractured forearm. | Sep 27 |
| Tigers | JaCoby Jones | OF | Out indefinitely | Fractured left hand | JaCoby Jones diagnosed with fractured hand. | Sep 2 |
| Tigers | Willi Castro | IF | Out indefinitely | Sore right shoulder | Willi Castro placed on IL. | Sep 27 |
 Astros | Justin Verlander | P | Out for season | Tommy John surgery | Justin Verlander to undergo Tommy John surgery. | Sep 19 |
| Astros | Yordan Alvarez | OF | Out for season | Right knee surgery | Yordan Alvarez to undergo knee surgery; to miss rest of season. | Aug 19 |
 Royals | Bubba Starling | OF | Out indefinitely | Right lower back spasms | Bubba Starling placed on 10-day IL. | Sep 23 |
| Royals | Jorge Soler | OF | Out indefinitely | Strained right oblique | Jorge Soler placed on 10-day IL. | Sep 25 |
 Angels | Franklin Barreto | IF | Out indefinitely | Left shoulder subluxation | Franklin Barreto to be placed on 10-day IL. | Sep 8 |
| Angels | Dillon Peters | P | Out indefinitely | Oblique | Peters is injured with oblique | Jul 2 |
| Angels | Luis Rengifo | IF | Out indefinitely | Strained right hamstring | Luis Rengifo to be placed on 10-day IL. | Sep 26 |
 Dodgers | David Price | P | Out for season | Personal | Price is out for season with personal | Jul 5 |
 Marlins | Harold Ramirez | OF | Out indefinitely | Strained left hamstring | Harold Ramirez placed on 10-day IL. | Sep 6 |
| Marlins | Isan Díaz | IF | Out for season | Tight left groin | Isan Diaz placed on 60-day IL. | Sep 15 |
| Marlins | Elieser Hernandez | P | Out indefinitely | Strained right lat | Elieser Hernandez placed on 10-day IL. | Sep 2 |
 Brewers | Luke Maile | C | Out indefinitely | Fractured right index finger | Maile is injured with finger | Jul 18 |
| Brewers | Lorenzo Cain | OF | Out for season | Personal | Cain is out for season with personal | Aug 20 |
| Brewers | Manny Piña | C | Out for season | Right knee surgery | Manny Pina to undergo season-ending knee surgery. | Aug 28 |
| Brewers | Corbin Burnes | P | Out indefinitely | Strained left oblique | Corbin Burnes placed on 10-day IL. | Sep 25 |
 Twins | Brent Rooker | OF | Out for season | Fractured right forearm | Brent Rooker to miss rest of season with fractured forearm. | Sep 13 |
 Mets | Marcus Stroman | P | Out for season | Personal | Marcus Stroman opts out of season. | Aug 10 |
| Mets | Michael Conforto | OF | Out indefinitely | Tight hamstring | Michael Conforto placed on IL. | Sep 24 |
| Mets | Robert Gsellman | P | Out indefinitely | Fractured rib | Robert Gsellman placed on 10-day IL. | Sep 9 |
| Mets | Noah Syndergaard | P | Out for season | Tommy John surgery | Syndergaard is out for season with elbow | Jul 2 |
| Mets | Wilfredo Tovar | IF | Out indefinitely | Coronavirus | Tovar is injured with illness | Jul 17 |
 Yankees | Luis Severino | P | Out for season | Tommy John surgery | Severino is out for season with elbow | Jul 2 |
| Yankees | Corey Kluber | P | Out for season | Torn right shoulder muscle | Corey Kluber to miss rest of season. | Sep 5 |
| Yankees | Nestor Cortes Jr. | P | Out indefinitely | Left elbow impingement | Nestor Cortes placed on 10-day IL. | Aug 15 |
 Athletics | A.J. Puk | P | Out indefinitely | Shoulder surgery | AJ Puk to undergo shoulder surgery. | Sep 11 |
| Athletics | Matt Chapman | IF | Out for season | Right hip surgery | Matt Chapman to undergo season-ending hip surgery. | Sep 12 |
 Phillies | Rhys Hoskins | IF | Out indefinitely | Strained left elbow | Rhys Hoskins to be placed on 10-day IL. | Sep 15 |
| Phillies | Kyle Garlick | OF | Out indefinitely | Strained right oblique | Kyle Garlick placed on 10-day IL. | Sep 16 |
 Pirates | Jameson Taillon | P | Out for season | Tommy John surgery | Taillon is out for season with elbow | Jul 2 |
| Pirates | Jacob Stallings | C | Out indefinitely | Concussion | Jacob Stallings placed on 7-day concussion IL. | Sep 27 |
| Pirates | Anthony Alford | OF | Out indefinitely | Fractured right elbow | Anthony Alford diagnosed with fractured elbow. | Sep 6 |
| Pirates | Kevin Newman | IF | Out indefinitely | Left knee contusion | Kevin Newman placed on 10-day IL. | Sep 20 |
| Pirates | Phillip Evans | IF | Out indefinitely | Broken jaw, concussion | Phillip Evans diagnosed with broken jaw, concussion. | Aug 9 |
| Pirates | Cole Tucker | OF | Out indefinitely | Concussion | Cole Tucker placed on 7-day concussion IL. | Sep 17 |
| Pirates | Kevin Kramer | OF | Out for season | Right hip surgery | Kramer is out for season with hip | Jul 2 |
 Padres | Luis Campusano | C | Out indefinitely | Sprained left wrist | Luis Campusano placed on 10-day IL. | Sep 6 |
 Giants | Buster Posey | C | Out for season | Personal | Posey is out for season with personal | Jul 10 |
| Giants | Luis Alexander Basabe | OF | Out indefinitely | Strained right hamstring | Luis Basabe placed on 10-day IL. | Sep 23 |
| Giants | Tyler Beede | P | Out for season | Tommy John surgery | Beede is out for season with elbow | Jul 2 |
| Giants | Chadwick Tromp | C | Out indefinitely | Strained right shoulder | Chadwick Tromp placed on 10-day IL. | Sep 23 |
 Mariners | Tom Murphy | C | Out indefinitely | Fractured left foot | Murphy is injured with foot | Aug 5 |
| Mariners | Mitch Haniger | OF | Out indefinitely | Back | Haniger is injured with back | Jul 2 |
| Mariners | Dylan Moore | OF | Out indefinitely | Concussion | Dylan Moore placed on 7-day concussion list. | Sep 22 |
| Mariners | Luis Torrens | C | Out indefinitely | Back spasms | Luis Torrens placed on 10-day IL. | Sep 27 |
| Mariners | Jake Fraley | OF | Out indefinitely | Strained right quad | Jake Fraley to be placed on 10-day IL. | Sep 23 |
| Mariners | Shed Long Jr. | IF | Out indefinitely | Right shin stress fracture | Shed Long placed on 10-day IL. | Sep 12 |
| Mariners | Sam Haggerty | OF | Out indefinitely | Strained left forearm | Sam Haggerty placed on 10-day IL. | Sep 7 |
 Cardinals | Carlos Martínez | P | Out for season | Personal, oblique | Carlos Martinez to miss rest of playoffs. | Sep 30 |
| Cardinals | Dakota Hudson | P | Out indefinitely | Tommy John surgery | Dakota Hudson to undergo Tommy John surgery. | Sep 27 |
| Cardinals | Miles Mikolas | P | Out for season | Right flexor tendon | Miles Mikolas to undergo season-ending forearm surgery. | Jul 28 |
 Rays | Andrew Kittredge | P | Out indefinitely | Sprained right UCL | Andrew Kittredge placed on 45-day IL. | Aug 12 |
| Rays | Brendan McKay | P | Out indefinitely | Left shoulder surgery | Brendan McKay to undergo season-ending shoulder surgery. | Aug 18 |
| Rays | Yonny Chirinos | P | Out for season | Strained right elbow | Yonny Chirinos to miss rest of season. | Aug 21 |
 Rangers | Elvis Andrus | IF | Out indefinitely | Strained back | Elvis Andrus to be placed on 10-day IL. | Sep 12 |
| Rangers | David Dahl | OF | Out indefinitely | Strained right shoulder | David Dahl placed on 45-day IL. | Sep 23 |
| Rangers | Jason Martin | OF | Out indefinitely | Undisclosed | Martin is injured with undisclosed | Sep 21 |
| Rangers | Jose Trevino | C | Out indefinitely | Left wrist impingement | Jose Trevino placed on 10-day IL. | Sep 13 |
| Rangers | Aramis Garcia | C | Out indefinitely | Hip | Garcia is injured with hip | Jul 2 |
| Rangers | Sherten Apostel | IF | Out indefinitely | Tight low back | Sherten Apostel (back) placed on 10-day IL. | Sep 27 |
| Rangers | Brock Burke | P | Out for season | Out for season | Burke is out for season with shoulder | Jul 2 |
 Blue Jays | Breyvic Valera | IF | Out indefinitely | Restricted list | Valera is injured with undisclosed | Sep 28 |
| Blue Jays | Derek Fisher | OF | Out indefinitely | Right knee contusion | Derek Fisher to be placed on 10-day IL. | Sep 16 |
| Blue Jays | Trent Thornton | P | Out indefinitely | Right elbow inflammation | Trent Thornton placed on 10-day IL. | Aug 24 |
 Nationals | Starlin Castro | IF | Out indefinitely | Right wrist surgery | Starlin Castro to undergo wrist surgery. | Aug 18 |
| Nationals | Welington Castillo | C | Out for season | Personal | Castillo is out for season with personal | Jul 5 |
| Nationals | Joe Ross | P | Out for season | Personal | Ross is out for season with personal | Jul 5 |
| Nationals | Stephen Strasburg | P | Out for season | Right hand carpal tunnel neuritis | Stephen Strasburg to undergo season-ending hand surgery. | Aug 22 |
| Nationals | Carter Kieboom | IF | Out indefinitely | Left wrist contusion | Carter Kieboom placed on 10-day IL. | Sep 23 |