 Diamondbacks | Mike Leake | P | Out for season | Personal | Leake is out for season with personal | Jul 4 |
| Diamondbacks | Domingo Leyba | IF | Suspended | Suspension | Leyba is suspended with suspension | Jul 4 |
 Braves | Félix Hernández | P | Out for season | Personal | Hernandez is out for season with personal | Jul 0 |
| Braves | Peter O'Brien | OF | Out indefinitely | Left ribcage contusion | Peter O'Brien placed on 10-day IL. | May 6 |
| Braves | Freddie Freeman | IF | Out indefinitely | Coronavirus | Freeman is injured with illness | Jul 0 |
| Braves | Nick Markakis | OF | Out for season | Personal | Markakis is out for season with personal | Jul 1 |
 Orioles | Trey Mancini | OF | Out for season | Colon cancer | Mancini is out for season with abdomen | Jul 4 |
 Red Sox | Dustin Pedroia | IF | Out indefinitely | Left knee | Pedroia is injured with knee | Jul 4 |
| Red Sox | Chris Sale | P | Out for season | Tommy John surgery | Sale is out for season with elbow | Jul 4 |
 Cubs | José Quintana | P | Out indefinitely | Left thumb surgery | Quintana is injured with thumb | Jul 0 |
 White Sox | Carlos Rodón | P | Out indefinitely | Left elbow | Rodon is injured with elbow | Jul 4 |
| White Sox | Nicky Delmonico | OF | Out for season | Left shoulder surgery | Nicky Delmonico underwent season-ending shoulder surgery. | Jun 2 |
 Rockies | Ian Desmond | OF | Out for season | Personal | Desmond is out for season with personal | Jul 4 |
 Tigers | Michael Fulmer | P | Out indefinitely | Tommy John surgery | Fulmer is injured with arm | Jul 4 |
 Royals | Salvador Pérez | C | Out indefinitely | Coronavirus | Perez is injured with illness | Jul 0 |
 Angels | Dillon Peters | P | Out indefinitely | Oblique | Peters is injured with oblique | Jul 4 |
| Angels | Griffin Canning | P | Out indefinitely | Right elbow | Canning is injured with elbow | Jul 4 |
 Dodgers | David Price | P | Out for season | Personal | Price is out for season with personal | Jul 0 |
 Brewers | Keon Broxton | OF | Out | One-game suspension | Broxton is out with suspension | Sep 1 |
 Twins | Michael Pineda | P | Suspended | 60-game suspension | Pineda is suspended with suspension | Jul 4 |
| Twins | Miguel Sanó | IF | Out indefinitely | Coronavirus | Sano is injured with illness | Jul 0 |
| Twins | Rich Hill | P | Out indefinitely | Elbow | Hill is injured with elbow | Jul 4 |
| Twins | Willians Astudillo | C | Out indefinitely | Coronavirus | Astudillo is injured with illness | Jul 0 |
 Mets | Jed Lowrie | IF | Out indefinitely | Knee | Lowrie is injured with knee | Jul 4 |
| Mets | Yoenis Céspedes | OF | Out indefinitely | Right ankle | Cespedes is injured with ankle | Jul 4 |
| Mets | Noah Syndergaard | P | Out for season | Tommy John surgery | Syndergaard is out for season with elbow | Jul 4 |
 Yankees | Luis Severino | P | Out for season | Tommy John surgery | Severino is out for season with elbow | Jul 4 |
| Yankees | Masahiro Tanaka | P | Out indefinitely | Concussion | Tanaka is injured with concussion | Jul 0 |
| Yankees | Domingo Germán | P | Suspended | Suspension | German is suspended with suspension | Jul 4 |
| Yankees | Aaron Judge | OF | Out indefinitely | Ribs | Judge is injured with ribs | Jul 4 |
 Athletics | Daniel Mengden | P | Out indefinitely | Right elbow | Mengden is injured with elbow | Jul 4 |
 Phillies | Aaron Nola | P | Out indefinitely | Undisclosed | Nola is injured with undisclosed | Jul 0 |
| Phillies | Scott Kingery | IF | Out indefinitely | Undisclosed | Kingery is injured with undisclosed | Jul 4 |
 Pirates | Chris Archer | P | Out for season | Neck, shoulder surgery | Archer is out for season with shoulder | Jul 4 |
| Pirates | Jameson Taillon | P | Out for season | Tommy John surgery | Taillon is out for season with elbow | Jul 4 |
| Pirates | Kevin Kramer | OF | Out for season | Right hip surgery | Kramer is out for season with hip | Jul 4 |
 Giants | Tyler Beede | P | Out for season | Tommy John surgery | Beede is out for season with elbow | Jul 4 |
| Giants | Aramis Garcia | C | Out indefinitely | Hip | Garcia is injured with hip | Jul 4 |
 Mariners | Mitch Haniger | OF | Out indefinitely | Back | Haniger is injured with back | Jul 4 |
 Rangers | Brock Burke | P | Out for season | Out for season | Burke is out for season with shoulder | Jul 4 |
 Blue Jays | Brandon Drury | OF | Out indefinitely | Undisclosed | Drury is injured with undisclosed | Jul 4 |
| Blue Jays | Hector Perez | P | Out indefinitely | Undisclosed | Perez is injured with undisclosed | Jul 4 |
| Blue Jays | Jonathan Davis | OF | Out indefinitely | Undisclosed | Davis is injured with undisclosed | Jul 4 |
 Nationals | Welington Castillo | C | Out for season | Personal | Castillo is out for season with personal | Jul 0 |
| Nationals | Ryan Zimmerman | IF | Out for season | Personal | Zimmerman is out for season with personal | Jul 4 |
| Nationals | Joe Ross | P | Out for season | Personal | Ross is out for season with personal | Jul 0 |