 Diamondbacks | Josh Reddick | OF | Out | Illness | Reddick is out with illness | Jul 31 |
| Diamondbacks | Luke Weaver | P | Out indefinitely | Right shoulder discomfort | Luke Weaver to be placed on 10-day IL. | May 18 |
| Diamondbacks | Seth Frankoff | P | Out indefinitely | Sore right forearm | Seth Frankoff placed on 10-day IL. | Jun 4 |
| Diamondbacks | Pavin Smith | OF | Out | Health and safety protocols | Pavin Smith placed on injured list. | Jul 30 |
| Diamondbacks | Josh Rojas | IF | Out indefinitely | Dislocated left finger | Josh Rojas placed on 10-day IL. | Jul 24 |
 Braves | Eddie Rosario | OF | Out indefinitely | Strained abdominal | Eddie Rosario placed on 10-day IL. | Jul 7 |
| Braves | Travis d'Arnaud | C | Out indefinitely | Left thumb surgery | Travis d'Arnaud to undergo thumb surgery. | May 2 |
| Braves | Marcell Ozuna | OF | Out indefinitely | Dislocated left ring, middle finger | Ozuna is injured with finger | May 30 |
| Braves | Ian Anderson | P | Out indefinitely | Right shoulder inflammation | Ian Anderson placed on 10-day IL. | Jul 16 |
| Braves | Mike Soroka | P | Out indefinitely | Torn right Achilles tendon | Soroka is injured with achilles | May 28 |
| Braves | Ronald Acuña Jr. | OF | Out for season | Torn right ACL | Ronald Acuna Jr. to undergo season-ending ACL surgery. | Jul 11 |
| Braves | Tucker Davidson | P | Out indefinitely | Strained left forearm | Tucker Davidson to be placed on 10-day IL. | Jun 16 |
| Braves | Huascar Ynoa | P | Out indefinitely | Broken hand | Huascar Ynoa out a couple months with broken hand from punching dugout bench. | May 17 |
 Orioles | Chris Davis | IF | Out for season | Left hip surgery | Chris Davis underwent season-ending hip surgery. | May 19 |
| Orioles | Keegan Akin | P | Probable | COVID-19 list | Akin is probable with illness | Jul 31 |
| Orioles | Bruce Zimmermann | P | Out indefinitely | Left bicep tendonitis | Bruce Zimmermann placed on 10-day IL. | Jun 18 |
 Red Sox | Danny Santana | OF | Out indefinitely | Strained left groin | Danny Santana to be placed on IL. | Jul 22 |
| Red Sox | Marwin Gonzalez | IF | Out indefinitely | Strained right hamstring | Marwin Gonzalez placed on 10-day IL. | Jul 16 |
| Red Sox | Kyle Schwarber | OF | Out indefinitely | Strained right hamstring | Kyle Schwarber to miss time with significant hamstring strain. | Jul 3 |
| Red Sox | Christian Arroyo | IF | Out indefinitely | Strained left hamstring | Christian Arroyo placed on 10-day IL. | Jul 19 |
 Cubs | Austin Romine | C | Out indefinitely | Sprained left wrist | Austin Romine placed on 10-day IL. | Apr 26 |
| Cubs | Jose Lobaton | C | Out indefinitely | Sprained right shoulder | Jose Lobaton placed on 60-day IL. | Jun 30 |
| Cubs | P.J. Higgins | C | Out indefinitely | Strained right forearm | P.J. Higgins (forearm) placed on 10-day IL. | Jun 11 |
| Cubs | Johneshwy Fargas | OF | Out indefinitely | Sprained AC joint | Fargas is injured with shoulder | May 26 |
| Cubs | Nick Madrigal | IF | Out for season | Right hamstring surgery | Nick Madrigal underwent season-ending hamstring surgery. | Jun 15 |
| Cubs | Nico Hoerner | IF | Out indefinitely | Strained right oblique | Nico Hoerner placed on 10-day IL. | Jul 29 |
 White Sox | Yasmani Grandal | C | Out indefinitely | Torn left knee tendon | Yasmani Grandal diagnosed with torn knee tendon. | Jul 6 |
| White Sox | Jake Lamb | OF | Out indefinitely | Strained right quad | Jake Lamb placed on 10-day IL. | Jun 29 |
| White Sox | Eloy Jiménez | OF | Out | Tight right groin | Jimenez is out with groin | Jul 31 |
| White Sox | Luis Robert | OF | Out indefinitely | Strained hip flexor | Luis Robert (hip) to miss 12-16 weeks. | May 3 |
 Reds | Mike Moustakas | IF | Out indefinitely | Right heel contusion | Moustakas is injured with heel | Jul 15 |
| Reds | Nick Castellanos | OF | Out indefinitely | Right wrist microfracture | Nick Castellanos could be out a couple weeks. | Jul 22 |
| Reds | Nick Senzel | OF | Out indefinitely | Left knee surgery | Nick Senzel to undergo knee surgery; expected to miss 4-6 weeks. | May 26 |
| Reds | Alex Blandino | IF | Out indefinitely | Broken right hand | Alex Blandino placed on 10-day IL. | Jun 5 |
 Indians | Josh Naylor | OF | Out indefinitely | Fractured, dislocated right ankle | Josh Naylor diagnosed with fractured ankle. | Jun 28 |
| Indians | Bobby Bradley | IF | Out | Bereavement list | Bobby Bradley placed on bereavement list. | Jul 30 |
| Indians | Aaron Civale | P | Out indefinitely | Sprained right middle finger | Aaron Civale to miss 4-5 weeks with sprained finger. | Jun 23 |
| Indians | Shane Bieber | P | Out indefinitely | Strained right shoulder | Shane Bieber to be placed on IL. | Jun 14 |
 Rockies | Ian Desmond | OF | Out for season | Personal | Desmond is out for season with personal | Mar 30 |
| Rockies | Chi Chi González | P | Out indefinitely | Covid-19 protocols | Chi Chi Gonzalez placed in COVID-19 protocols. | Jul 28 |
| Rockies | Chris Owings | IF | Out indefinitely | Left thumb mallet finger | Chris Owings placed on 10-day IL. | Jul 20 |
| Rockies | Antonio Senzatela | P | Out | COVID-19 protocols | Antonio Senzatela scratched from start Friday. | Jul 16 |
| Rockies | Peter Lambert | P | Out indefinitely | Tommy John surgery | Lambert is injured with elbow | Mar 30 |
| Rockies | Yonathan Daza | OF | Out | COVID-19 list | Yonathan Daza placed on COVID-19 IL. | Jul 16 |
 Tigers | Matthew Boyd | P | Out indefinitely | Left arm discomfort | Matthew Boyd placed on 10-day IL. | Jun 15 |
| Tigers | José Ureña | P | Out indefinitely | Strained right groin | Jose Urena placed on 10-day IL. | Jul 17 |
| Tigers | Julio Teheran | P | Out indefinitely | Strained right shoulder | Julio Teheran placed on 10-day IL. | Apr 10 |
| Tigers | Spencer Turnbull | P | Out for season | Tommy John surgery | Spencer Turnbull to undergo Tommy John surgery. | Jul 20 |
| Tigers | Daz Cameron | OF | Out indefinitely | Right toe | Daz Cameron placed on 10-day IL. | Jul 7 |
| Tigers | Niko Goodrum | OF | Out indefinitely | Left calf contusion | Niko Goodrum placed on 10-day IL. | Jul 17 |
| Tigers | Isaac Paredes | IF | Out indefinitely | Strained right hip | Isaac Paredes placed on 10-day IL. | Jul 22 |
 Astros | Justin Verlander | P | Out indefinitely | Tommy John surgery | Verlander is injured with arm | Mar 30 |
| Astros | Alex Bregman | IF | Out indefinitely | Strained left quad | Alex Bregman placed on 10-day IL. | Jun 17 |
| Astros | José Urquidy | P | Out indefinitely | Right shoulder discomfort | Jose Urquidy placed on 10-day IL. | Jun 30 |
 Royals | Adalberto Mondesi | IF | Out indefinitely | Strained left oblique | Adalberto Mondesi placed on 10-day IL. | Jun 21 |
| Royals | Brady Singer | P | Out indefinitely | Right shoulder fatigue | Brady Singer placed on 10-day IL. | Jul 20 |
| Royals | Emmanuel Rivera | IF | Out indefinitely | Fractured left hamate | Emmanuel Rivera diagnosed with fractured wrist. | Jun 30 |
 Angels | Alex Cobb | P | Out indefinitely | Right wrist inflammation | Alex Cobb placed on 10-day IL. | Jul 31 |
| Angels | Mike Trout | OF | Out indefinitely | Strained right calf | Mike Trout placed on 10-day IL. | May 18 |
| Angels | Dexter Fowler | OF | Out indefinitely | Torn ACL | Dexter Fowler diagnosed with torn ACL. | Apr 11 |
| Angels | Anthony Rendon | IF | Out indefinitely | Strained left hamstring | Anthony Rendon placed on 10-day IL. | Jul 6 |
| Angels | Franklin Barreto | IF | Out for season | Tommy John surgery | Franklin Barreto to undergo Tommy John surgery. | May 11 |
| Angels | Jared Walsh | IF | Out indefinitely | Strained right intercostal | Jared Walsh placed on 10-day IL. | Jul 28 |
 Dodgers | Mookie Betts | OF | Out indefinitely | Right hip inflammation | Mookie Betts placed on 10-day IL. | Jul 25 |
| Dodgers | Danny Duffy | P | Out indefinitely | Strained left flexor | Danny Duffy placed on 10-day IL. | Jul 20 |
| Dodgers | Trevor Bauer | P | Out | Legal | Trevor Bauer placed on administrative leave. | Jul 2 |
| Dodgers | Corey Seager | IF | Out | Rest | Seager is out with rest | Jul 31 |
| Dodgers | Clayton Kershaw | P | Out indefinitely | Left forearm inflammation | Clayton Kershaw placed on 10-day IL. | Jul 7 |
| Dodgers | Trea Turner | IF | Out | COVID-19 | Turner is out with illness | Jul 28 |
| Dodgers | Gavin Lux | IF | Out indefinitely | Strained left hamstring | Gavin Lux placed on 10-day IL. | Jul 19 |
| Dodgers | Edwin Ríos | IF | Out for season | Torn labrum | Edwin Rios to undergo season ending surgery. | May 12 |
| Dodgers | Dustin May | P | Out for season | Tommy John surgery | Dustin May to undergo Tommy John surgery. | May 3 |
| Dodgers | Tony Gonsolin | P | Out indefinitely | Right shoulder inflammation | Tony Gonsolin placed on 10-day IL. | Jul 31 |
| Dodgers | Yoshi Tsutsugo | OF | Out indefinitely | Strained right calf | Yoshitomo Tsutsugo placed on 10-day IL. | Jun 9 |
 Marlins | Cody Poteet | P | Out indefinitely | Sprained right knee | Cody Poteet placed on 10-day IL. | Jun 29 |
| Marlins | Sixto Sánchez | P | Out for season | Right shoulder surgery | Sixto Sanchez to undergo season-ending shoulder surgery. | Jul 5 |
| Marlins | Jon Berti | IF | Out indefinitely | Concussion | Jon Berti diagnosed with concussion. | Jul 23 |
| Marlins | Garrett Cooper | OF | Out for season | Elbow surgery | Garrett Cooper to undergo season-ending surgery. | Jul 28 |
| Marlins | Pablo López | P | Out indefinitely | Strained right rotator cuff | Pablo Lopez placed on 10-day IL. | Jul 17 |
| Marlins | José Devers | IF | Out indefinitely | Right shoulder discomfort | Jose Devers placed on IL. | Jun 14 |
| Marlins | Elieser Hernandez | P | Out indefinitely | Strained quad | Elieser Hernandez (quad) to be placed on 10-day IL. | Jun 4 |
| Marlins | Jesús Sánchez | OF | Out indefinitely | Undisclosed | Jesus Sanchez placed on IL. | Jul 16 |
 Brewers | Travis Shaw | IF | Out indefinitely | Dislocated left shoulder | Shaw is injured with shoulder | Jun 13 |
| Brewers | Daniel Vogelbach | IF | Out indefinitely | Strained left hamstring | Dan Vogelbach to be placed on IL. | Jun 23 |
| Brewers | Christian Yelich | OF | Out indefinitely | COVID-19 | Christian Yelich tests positive for COVID-19; placed on IL. | Jul 27 |
| Brewers | Jace Peterson | IF | Out indefinitely | COVID-19 IL | Jace Peterson placed on COVID-19 IL. | Jul 27 |
 Twins | Josh Donaldson | IF | Out | Tight right hamstring | Donaldson is out with hamstring | Jul 31 |
| Twins | Rob Refsnyder | OF | Out indefinitely | Strained left hamstring | Rob Refsnyder placed on 10-day IL. | Jun 14 |
| Twins | Byron Buxton | OF | Out indefinitely | Fractured left hand | Byron Buxton diagnosed with fractured hand. | Jun 22 |
| Twins | Keon Broxton | OF | Out | One-game suspension | Broxton is out with suspension | Sep 2 |
| Twins | Alex Kirilloff | OF | Out indefinitely | Right wrist surgery | Alex Kirilloff to undergo wrist surgery. | Jul 21 |
| Twins | Kyle Garlick | OF | Out indefinitely | Sports hernia | Kyle Garlick to be placed on IL. | Jun 9 |
| Twins | Randy Dobnak | P | Out indefinitely | Strained right middle finger | Randy Dobnak placed on 10-day IL. | Jun 24 |
 Mets | Francisco Lindor | IF | Out indefinitely | Strained right oblique | Francisco Lindor placed on 10-day IL. | Jul 17 |
| Mets | José Peraza | IF | Out indefinitely | Fractured right middle finger | Jose Peraza placed on 10-day IL. | Jul 20 |
| Mets | Brandon Nimmo | OF | Out | Tight hamstring | Nimmo is out with hamstring | Jul 31 |
| Mets | Jacob deGrom | P | Out indefinitely | Tight right forearm | Jacob deGrom placed on 10-day IL. | Jul 18 |
| Mets | Noah Syndergaard | P | Out indefinitely | Tommy John surgery | Syndergaard is injured with elbow | Mar 30 |
| Mets | Thomas Szapucki | P | Out for season | Ulnar nerve transposition surgery | Szapucki is out for season with arm | Jul 13 |
| Mets | David Peterson | P | Out indefinitely | Sore right side | David Peterson placed on 10-day IL. | Jul 2 |
| Mets | Robert Stock | P | Out indefinitely | Strained right hamstring | Robert Stock placed on 10-day IL. | Jul 21 |
| Mets | Joey Lucchesi | P | Out for season | Torn left UCL | Joey Lucchesi to undergo Tommy John surgery. | Jun 22 |
| Mets | Jordan Yamamoto | P | Out indefinitely | Sore right shoulder | Jordan Yamamoto placed on 10-day IL. | May 25 |
 Yankees | Aaron Hicks | OF | Out for season | Left wrist surgery | Aaron Hicks expected to miss the rest of the season. | May 27 |
| Yankees | Luis Severino | P | Out indefinitely | Tommy John surgery | Severino is injured with elbow | Mar 30 |
| Yankees | Gio Urshela | IF | Out | Tight hamstring | Urshela is out with hamstring | Jul 31 |
| Yankees | Corey Kluber | P | Out indefinitely | Strained subcap | Corey Kluber expected to miss more than 4 weeks. | May 26 |
| Yankees | DJ LeMahieu | IF | Out | Strained triceps | LeMahieu is out with triceps | Jul 31 |
| Yankees | Luke Voit | IF | Out indefinitely | Left knee bone bruise | Luke Voit placed on 10-day IL. | Jul 16 |
| Yankees | Tim Locastro | OF | Out indefinitely | Torn right ACL | Tim Locastro diagnosed with torn ACL. | Jul 18 |
| Yankees | Clint Frazier | OF | Out indefinitely | Vertigo | Clint Frazier placed on 10-day IL. | Jul 2 |
| Yankees | Miguel Andújar | OF | Out indefinitely | Strained left wrist | Miguel Andujar placed on 10-day IL. | Jul 10 |
| Yankees | Greg Allen | OF | Out | Sore right knee | Allen is out with knee | Jul 31 |
| Yankees | Trey Amburgey | OF | Out indefinitely | Strained right hamstring | Trey Amburgey placed on 10-day IL. | Jul 20 |
| Yankees | Michael King | P | Out indefinitely | Right middle finger contusion | Michael King placed on 10-day IL. | Jul 8 |
| Yankees | Chris Gittens | IF | Out indefinitely | Ankle | Chris Gittens to be placed on 10-day IL. | Jul 25 |
 Athletics | Mike Fiers | P | Out indefinitely | Sprained right elbow | Mike Fiers placed on 10-day IL. | May 8 |
| Athletics | Chad Pinder | OF | Out indefinitely | Strained right hamstring | Chad Pinder placed on 10-day IL. | Jul 8 |
| Athletics | James Kaprielian | P | Out indefinitely | Right shoulder impingement | James Kaprielian placed on 10-day IL. | Jul 31 |
 Phillies | Freddy Galvis | IF | Out indefinitely | Strained right quad | Freddy Galvis placed on 10-day IL. | Jun 27 |
| Phillies | Roman Quinn | OF | Out for season | Ruptured left Achilles | Roman Quinn to undergo season-ending Achilles surgery. | May 31 |
| Phillies | Matt Joyce | OF | Out indefinitely | Strained low back | Matt Joyce placed on 10-day IL. | Jun 19 |
| Phillies | Zach Eflin | P | Out indefinitely | Right patellar tendinitis | Zach Eflin placed on 10-day IL. | Jul 20 |
| Phillies | Andrew Knapp | C | Out | Paternity list | Andrew Knapp placed on paternity list. | Jul 29 |
| Phillies | Rhys Hoskins | IF | Out | Tweaked left groin | Hoskins is out with groin | Jul 31 |
 Pirates | Erik González | IF | Out indefinitely | Right side discomfort | Erik Gonzalez to be placed on 10-day IL. | Jul 2 |
| Pirates | Trevor Cahill | P | Out indefinitely | Fractured right foot | Cahill is injured with foot | Jul 28 |
| Pirates | Colin Moran | IF | Out indefinitely | Fractured left pisiform | Colin Moran diagnosed with fractured hand. | Jul 1 |
| Pirates | Steven Brault | P | Out indefinitely | Strained lat | Brault is injured with back | Mar 30 |
| Pirates | Chase De Jong | P | Out for season | Left knee surgery | Chase De Jong underwent season-ending knee surgery. | Jul 28 |
| Pirates | Ka'ai Tom | OF | Out indefinitely | Strained lower back | Ka'ai Tom placed on 10-day IL. | Jul 3 |
 Padres | Mike Clevinger | P | Out indefinitely | Tommy John surgery | Clevinger is injured with arm | Mar 30 |
| Padres | Fernando Tatis Jr. | IF | Out indefinitely | Left shoulder subluxation | Fernando Tatis Jr. to be placed on 10-day IL. | Jul 31 |
| Padres | Chris Paddack | P | Out indefinitely | Strained left oblique | Chris Paddack placed on 10-day IL. | Jul 31 |
| Padres | Adrian Morejon | P | Out indefinitely | Tommy John surgery | Adrian Morejon to undergo Tommy John surgery. | Apr 20 |
| Padres | Dinelson Lamet | P | Out indefinitely | Right forearm inflammation | Dinelson Lamet placed on 10-day IL. | Jun 27 |
 Giants | Evan Longoria | IF | Out indefinitely | Sprained left shoulder | Evan Longoria to be placed on 10-day IL. | Jun 6 |
| Giants | Tommy La Stella | IF | Out indefinitely | Fractured right thumb | La Stella is injured with thumb | Jun 26 |
| Giants | Brandon Belt | IF | Out indefinitely | Right knee inflammation | Brandon Belt (knee) placed on 10-day IL. | Jun 25 |
| Giants | Jaylin Davis | OF | Out indefinitely | Strained left hamstring | Jaylin Davis placed on 10-day IL. | Jul 6 |
| Giants | Sammy Long | P | Out indefinitely | Strained low back | Sammy Long placed on 10-day IL. | Jul 5 |
 Mariners | James Paxton | P | Out indefinitely | Tommy John surgery | James Paxton to undergo Tommy John surgery. | Apr 13 |
| Mariners | Kyle Lewis | OF | Out indefinitely | Torn right meniscus | Kyle Lewis diagnosed with torn meniscus. | Jun 1 |
| Mariners | Justin Dunn | P | Out indefinitely | Right shoulder inflammation | Justin Dunn placed on 10-day IL. | Jun 18 |
| Mariners | Justus Sheffield | P | Out indefinitely | Strained left forearm | Justus Sheffield placed on 10-day IL. | Jul 8 |
| Mariners | Jake Fraley | OF | Out | COVID-19 list | Jake Fraley placed on injured list. | Jul 18 |
| Mariners | Evan White | IF | Out for season | Hip flexor | Evan White to undergo season-ending surgery. | Jul 16 |
| Mariners | Ljay Newsome | P | Out indefinitely | Right elbow inflammation | Ljay Newsome placed on 10-day IL. | May 9 |
| Mariners | Sam Haggerty | OF | Out indefinitely | Right shoulder inflammation | Sam Haggerty placed on 10-day IL. | May 25 |
| Mariners | Nick Margevicius | P | Out indefinitely | Left shoulder inflammation | Nick Margevicius placed on 10-day IL. | Apr 26 |
 Cardinals | Max Moroff | IF | Out for season | Shoulder surgery | Max Moroff to undergo season-ending surgery. | Jun 6 |
| Cardinals | Carlos Martínez | P | Out for season | Right thumb surgery | Carlos Martinez likely out for season. | Jul 19 |
| Cardinals | Dakota Hudson | P | Out indefinitely | Tommy John surgery | Hudson is injured with elbow | Mar 30 |
| Cardinals | Wade LeBlanc | P | Out indefinitely | Left elbow stress reaction | Wade LeBlanc placed on 60-day IL. | Aug 25 |
| Cardinals | Jack Flaherty | P | Out indefinitely | Strained left oblique | Jack Flaherty to be placed on IL. | Jun 2 |
| Cardinals | Miles Mikolas | P | Out indefinitely | Tight forearm | Miles Mikolas placed on 10-day IL. | May 23 |
 Rays | Chris Archer | P | Out indefinitely | Tight right forearm | Chris Archer placed on 10-day IL. | Apr 10 |
| Rays | Tyler Glasnow | P | Out for season | Partially torn right UCL | Tyler Glasnow expected to undergo Tommy John surgery. | Jul 31 |
| Rays | Yonny Chirinos | P | Out indefinitely | Strained right elbow | Chirinos is injured with elbow | Mar 30 |
 Rangers | Willie Calhoun | OF | Out indefinitely | Fractured left forearm | Willie Calhoun diagnosed with fractured forearm. | Jun 27 |
| Rangers | Ronald Guzmán | IF | Out for season | Torn right meniscus | Ronald Guzman to miss rest of season. | Apr 23 |
| Rangers | Jacob Rogers | IF | Out indefinitely | Sore right arm | Jake Rogers placed on 10-day IL. | Jul 19 |
| Rangers | Kohei Arihara | P | Out indefinitely | Right middle finger contusion | Kohei Arihara placed on 10-day IL. | May 9 |
 Blue Jays | Corey Dickerson | OF | Out indefinitely | Left foot contusion | Dickerson is injured with foot | Jun 15 |
| Blue Jays | Danny Jansen | C | Out indefinitely | Strained right hamstring | Danny Jansen placed on 10-day injured list. | Jul 23 |
 Nationals | Starlin Castro | IF | Suspended | 30-game suspension | Starlin Castro suspended for 30 games. | Jul 30 |
| Nationals | Alex Avila | C | Out indefinitely | Strained bilateral calf | Alex Avila placed on 10-day IL. | Jul 3 |
| Nationals | Jordy Mercer | IF | Out indefinitely | Strained left calf | Jordy Mercer placed on 10-day IL. | Jul 24 |
| Nationals | Stephen Strasburg | P | Out for season | Thoracic outlet surgery | Stephen Strasburg to undergo season-ending thoracic outlet surgery. | Jul 27 |