Guardians vs. Twins Odds & Betting Predictions - May 21, 2025

Guardians at Twins

7:40 pm • MLB Network

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Cleveland Guardians

@

Minnesota Twins

pitcher		team	era	w-l
J.Ryan			0.00	0-0
T.Bibee			0.00	0-0

MatchupOpenSpreadTotalMoneyline
Guardians 25-21	+1.5	+1.5-205	o7.5+100	+116
Twins 26-21	u7	-1.5+168	u7.5-121	-136

location pin

Wednesday 7:40 p.m.

May 21, 2025

Target FieldMinneapolis

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50°Fahrenheit

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26%Rain

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4Wind

No props found

MLB Public Betting

Twins are 4-1 in their last 5 games.
Twins are 4-1 in their last 5 games against the spread
Twins are 13-13 in their road games against the spread
The totals have gone OVER in 1 of Twins' last 5 games
The totals have gone OVER in 7 of Twins' 21 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Twins	28-19	15-6	13-13	17-12	11-7
Guardians	20-26	11-11	9-15	9-10	11-15

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Twins	16-28-3	7-13-1	9-15-2	10-17-2	6-11-1
Guardians	21-22-3	8-13-1	13-9-2	11-8	10-13-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Twins	26-21	15-6	11-15	17-12	9-9
Guardians	25-21	14-8	11-13	13-6	12-14

date	opponent	score	spread	over/under	moneyline
May 18th	@MIL	L 2-5	+1.5 L	U 7.5	MIL +123
May 17th	@MIL	W 7-0	-1.5 W	U 7.5	MIN -125
May 17th	@MIL	W 3-0	-1.5 W	U 7.5	MIN -120
May 15th	@BAL	W 4-0	+1.5 W	U 9	MIN +112
May 14th	@BAL	W 8-6	+1.5 W	O 9	MIN +120

Shane Bieber
SP
Bieber is out with elbow
Out
John Means
SP
Means is out with elbow
Out
Lane Thomas
CF
Thomas is out with wrist
Out
David Fry
C
Fry is out with elbow
Out

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MatchupOverUnder
Guardians 25-21	N/A	N/A
Twins 26-21	N/A	N/A