Louisville vs. SMU Odds & Betting Predictions - November 22, 2025

Louisville at SMU

4:00 pm

Louisville Cardinals

@

SMU Mustangs

MatchupOpenSpreadTotalMoneyline
Louisville 7-1	N/A	N/A	N/A
SMU 6-3	N/A	N/A	N/A

location pin

Saturday 4:00 p.m.

November 22, 2025

Gerald J. Ford StadiumDallas

No props found

NCAAF Public Betting

SMU are 5-0 in their last 5 games.
SMU are 2-3 in their last 5 games against the spread
SMU are 1-3 in their road games against the spread
The totals have gone OVER in 0 of SMU' last 5 games
The totals have gone OVER in 1 of SMU' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
SMU	3-6	2-3	1-3	1-4	2-1
Louisville	3-5	0-5	3-0	2-5	1-0

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
SMU	2-7	1-4	1-3	1-4	1-2
Louisville	4-4	3-2	1-2	4-3	0-1

Straight-Up (ML) History

	overall	home	away	favorite	underdog
SMU	6-3	N/A	N/A	3-2	2-1
Louisville	7-1	N/A	N/A	6-1	1-0

date	opponent	score	spread	over/under	moneyline
Nov 1st	MIA	W 26-20	+8.5 W	U 50.5	SMU +260
Oct 25th	@WF	L 12-13	-5.5 L	U 52.5	WF -210
Oct 18th	@CLEM	W 35-24	+3.5 W	O 49.5	SMU +146
Oct 11th	STAN	W 34-10	-19.5 W	U 55.5	SMU -1100
Oct 4th	SYR	W 31-18	-17.5 L	U 57	SMU -850

Total

Passing

2016

YDS

2493

186/285

Comps/Atts

211/319

7.07

YPA

7.82

12/7

TDs/INTs

18/8

16/127

Sacks/Yards

15/147

Rushing

1246

Rush Yards

999

246

Attempts

271

5.07

YPC

3.69

18

TDs

14

Turnovers

Fumbles Lost

7

Interceptions

8

Efficiency

21/24 87.5%

Redzone

24/28 85.7%

43/106 0%

3rd Down

42/121 0%

3/6 0%

4th Down

6/10 0%

First Downs

165

Total

178

90

Pass

98

61

Rush

61

14

Penalty

19

Misc

/

Penalties/Yards

/

Could not load odds

See more NCAAF Odds

MatchupOverUnder
Louisville 7-1	N/A	N/A
SMU 6-3	N/A	N/A