Guardians vs. Twins Odds & Betting Predictions - September 20, 2025

Guardians at Twins

12:10 am • CLEG

Cleveland Guardians

6

6 - 2

Minnesota Twins

2

pitcher		team	era	w-l
P.Lopez			2.74	5-4
P.Messick			2.08	3-0

MatchupOpenSpreadTotalMoneyline
Guardians 82-71	+1.5	-1.5+146	o7.5-124	-113
Twins 66-87	u8	+1.5-186	u7.5-102	-108

location pin

Saturday 12:10 a.m.

September 20, 2025

Target FieldMinneapolis

Over 8+100

2u

CLE -110

0.91u

Under 8-120

1u

@cowhitchurch Best Bet https://myaction.app/7E4QiBJkNWb

CLE +100

0.5u

CLE +105

0.53u

Bet to -102

Guardians vs Twins: Pitcher's Duel For Friday Night
Collin Whitchurch•
Sep 19, 2025 UTC
3 FIRE Home Run Picks for Friday!
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Sep 19, 2025 UTC

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MLB Public Betting

Twins are 1-4 in their last 5 games.
Twins are 2-3 in their last 5 games against the spread
Twins are 37-38 in their road games against the spread
The totals have gone OVER in 4 of Twins' last 5 games
The totals have gone OVER in 39 of Twins' 78 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Twins	73-80	36-42	37-38	36-50	35-29
Guardians	82-71	37-38	45-33	32-31	49-38

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Twins	73-74-6	39-36-3	34-38-3	42-41-3	29-32-3
Guardians	66-81-6	34-38-3	32-43-3	32-30-1	33-49-5

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Twins	66-87	37-41	29-46	41-45	24-40
Guardians	82-71	41-34	41-37	41-22	41-46

date	opponent	score	spread	over/under	moneyline
Sep 17th	NYY	L 5-10	+1.5 L	O 9.5	NYY +134
Sep 16th	NYY	L 9-10	+1.5 W	O 9	NYY +144
Sep 15th	NYY	W 7-0	+1.5 W	U 9	MIN +163
Sep 14th	ARI	L 4-6	-1.5 L	O 9.5	ARI -125
Sep 13th	ARI	L 2-5	-1.5 L	U 8.5	ARI -135

Ben Lively
SP
Lively is out with elbow
Out
John Means
SP
Means is out with elbow
Out

Alan Roden
LF
Roden is out with thumb
Out

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PITCHER		PC	IP	K	ER
LP.Messick, P		94	5.1	9	2
RM.Festa, P		12	0.2	2	0
RJ.Junis, P		27	2	4	0
RC.Smith, P		12	1	1	0

HITTERS	H-AB	R	HR	RBI
1S.Kwan, LF	2-5	2	0	1
2A.Martinez, CF	1-5	0	0	1
3J.Ramirez, 3B	1-3	2	0	0
4K.Manzardo, 1B	0-3	1	0	0
4N.Jones, RF	0-0	0	0	0
4D.Schneemann, PH	0-1	0	0	0
4D.Schneemann, RF	0-1	0	0	0
5B.Naylor, C	2-4	0	0	4
6G.Arias, SS	1-4	0	0	0
7G.Valera, DH	1-1	0	0	0
7D.Fry, PH	1-2	1	0	0
7D.Fry, DH	1-2	1	0	0
8C.Kayfus, RF	0-2	0	0	0
8J.Noel, PH	0-2	0	0	0
8J.Noel, RF	0-2	0	0	0
8J.Noel, 1B	0-2	0	0	0
9B.Rocchio, 2B	0-4	0	0	0

PITCHER		PC	IP	K	ER
RP.Lopez, P		61	4	2	2
RC.Laweryson, P		20	2	2	0
LK.Funderburk, P		20	1.1	3	0
RC.Sands, P		25	0.2	2	2
RM.Tonkin, P		17	1	1	2

HITTERS	H-AB	R	HR	RBI
1B.Buxton, CF	0-4	0	0	0
2A.Martin, LF	1-4	1	0	0
3L.Keaschall, 2B	1-4	1	0	0
4B.Lee, SS	0-4	0	0	0
5R.Lewis, 3B	2-4	0	0	1
6K.Clemens, 1B	1-4	0	0	0
7C.McCusker, DH	1-2	0	0	0
7T.Larnach, PH	0-1	0	0	0
7T.Larnach, DH	0-1	0	0	0
8J.Pereda, C	0-2	0	0	0
8E.Julien, PH	0-1	0	0	0
8M.Gasper, C	0-1	0	0	0
9J.Outman, RF	0-2	0	0	0

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MatchupOverUnder
Guardians 82-71	o3.5-138	u3.5+106
Twins 66-87	o3.5-125	u3.5-104