Syracuse vs. Notre Dame Odds & Betting Predictions - November 22, 2025

Syracuse at Notre Dame

8:30 pm • NBC

Syracuse Orange

@

Notre Dame Fighting Irish

MatchupOpenSpreadTotalMoneyline
Syracuse 3-6	N/A	N/A	N/A
Notre Dame 6-2	N/A	N/A	N/A

location pin

Saturday 8:30 p.m.

November 22, 2025

Notre Dame StadiumSouth Bend

No props found

NCAAF Public Betting

Notre Dame are 4-1 in their last 5 games.
Notre Dame are 3-2 in their last 5 games against the spread
Notre Dame are 1-2 in their road games against the spread
The totals have gone OVER in 3 of Notre Dame' last 5 games
The totals have gone OVER in 2 of Notre Dame' 5 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Notre Dame	3-5	2-3	1-2	3-5	N/A
Syracuse	3-5-1	1-3-1	2-1	0-1-1	2-4

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Notre Dame	4-4	2-3	2-1	4-4	N/A
Syracuse	4-5	1-4	2-1	0-2	3-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Notre Dame	6-2	N/A	N/A	6-2	N/A
Syracuse	3-6	N/A	N/A	1-1	1-5

date	opponent	score	spread	over/under	moneyline
Nov 1st	@BC	W 25-10	-31.5 L	U 55.5	ND -8000
Oct 18th	USC	W 34-24	-10.5 L	U 60.5	ND -370
Oct 11th	NCST	W 36-7	-23.5 W	U 59.5	ND -2400
Oct 4th	BOISE	W 28-7	-21.5 L	U 63	ND -1600
Sep 27th	@ARK	W 56-13	-5.5 W	O 63.5	ND -218

Total

Passing

2323

YDS

2192

189/333

Comps/Atts

148/221

6.98

YPA

9.92

16/10

TDs/INTs

16/4

24/175

Sacks/Yards

10/83

Rushing

1011

Rush Yards

1501

303

Attempts

293

3.34

YPC

5.12

10

TDs

22

Turnovers

Fumbles Lost

10

Interceptions

4

Efficiency

26/33 78.8%

Redzone

29/39 74.4%

43/126 0%

3rd Down

39/88 0%

13/26 0%

4th Down

8/20 0%

First Downs

183

Total

188

101

Pass

98

67

Rush

73

15

Penalty

17

Misc

/

Penalties/Yards

/

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MatchupOverUnder
Syracuse 3-6	N/A	N/A
Notre Dame 6-2	N/A	N/A