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USC vs. Notre Dame Odds & Betting Predictions - October 18, 2025

USC at Notre Dame

11:30 pm • NBC

USC Trojans

4-0
24
24 - 34

Notre Dame Fighting Irish

3-0
34

USC at Notre Dame Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
USC
4-0
+10.5
+10.5-110
o60.5-105
+300
Notre Dame
3-0
u53.5
-10.5-110
u60.5-112
-370
location pinSaturday 11:30 p.m.
October 18, 2025
Notre Dame StadiumSouth Bend
USC vs. Notre Dame Expert Picks
Mike McNamara
Mike McNamara
Last 30d: 58-68-1 (+2.3u)
ND -200 (Live)
0.2u
Scott Rickenbach
Scott Rickenbach
Last 30d: 88-75-1 (+0.5u)
USC +10.5-115
0.87u
YBK Picks.com
Last 30d: 34-21-0 (+26.2u)
ND -10.5-105
2u
Topper
Topper
Last 30d: 178-190-5 (-21.0u)
Over 59.5-110
1u
Vegas Refund
Vegas Refund
Last 30d: 22-16-0 (+4.4u)
ND -10-110
1.1u
Kevin Thomas
Kevin Thomas
Last 30d: 0-4-0 (-4.0u)
USC +10.5-115
0.87u
Doug Ziefel
Doug Ziefel
Last 30d: 296-321-12 (+8.3u)
K.Miller Anytime TD Scorer Yes+136
0.37u
Action Analytics
Action Analytics
Last 30d: 15-29-0 (-16.5u)
USC +10-105
1.1u
Collin Whitchurch
Collin Whitchurch
Last 30d: 59-60-0 (+7.5u)
ND o34.5 Team Total+111
0.25u
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 45-37-0 (+7.7u)
J.Price o70.5 Rush Yds-115
1u
@_Collin1 https://podcasts.apple.com/us/podcast/college-football-week-8-betting-preview/id1579379256?i=1000732214184
ND o35 Team Total-109
1u
@_Collin1 https://podcasts.apple.com/us/podcast/college-football-week-8-betting-preview/id1579379256?i=1000732214184
Sandy Plashkes
Sandy Plashkes
Last 30d: 75-57-1 (+31.2u)
ND -9.5-110
2u
Mjaybrod
Mjaybrod
Last 30d: 46-43-1 (+2.1u)
ND -9.5-110
0.91u
TheDegenerateWeekly -9.5
Kody Malstrom
Kody Malstrom
Last 30d: 38-34-1 (+0.2u)
USC +10-110
0.55u
Doug Ziefel
Doug Ziefel
Last 30d: 296-321-12 (+8.3u)
USC +3.5 (1Q)-120
0.5u
Collin Wilson
Collin Wilson
Last 30d: 65-38-1 (+18.8u)
J.Price o61.5 Rush Yds-114
0.5u
Full writeup Action Network. Zone read efficiency poor for USC defense. Price best inside/outside rusher in Irish backfield by yards per carry. Averaging 70.3 rushing yards per game
ND o35.5 Team Total-105
1.05u
Full Writeup coming Action Network. Side is inflated w USC injuries on offense. Notre Dame extreme advantages in run concepts. Heavy rain expected early making a sloppy track
Doug Ziefel
Doug Ziefel
Last 30d: 296-321-12 (+8.3u)
Under 62.5-115
0.5u
Topper
Topper
Last 30d: 178-190-5 (-21.0u)
ND -7.5-110
0.91u

USC vs. Notre Dame Previews & Analysis

  • 2 Model Projection Plays Tonight article feature image

    2 Model Projection Plays Tonight

    Alex Kolodziej•
    Oct 18, 2025 UTC
  • USC vs. Notre Dame: 2 Bets for Saturday Night article feature image

    USC vs. Notre Dame: 2 Bets for Saturday Night

    Collin Wilson•
    Oct 18, 2025 UTC
  • Our +285 Parlay for USC vs. Notre Dame article feature image

    Our +285 Parlay for USC vs. Notre Dame

    Alex Hinton•
    Oct 18, 2025 UTC
  • Wilson's Week 8 NCAAF Betting Card article feature image

    Wilson's Week 8 NCAAF Betting Card

    Collin Wilson•
    Oct 18, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

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No props found

Line Movement Tracker

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USC vs. Notre Dame Public Betting Percentages

Away Logo

USC

Public

Home Logo

Notre Dame

58%

Bets%

42%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • Notre Dame are 3-0 in their last 5 games.
  • Notre Dame are 2-1 in their last 5 games against the spread
  • The totals have gone OVER in 1 of Notre Dame' last 3 games
  • The totals have gone OVER in 0 of Notre Dame' 2 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Notre Dame		2-11-1N/A1-1N/A
USC		1-31-20-11-2N/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Notre Dame		1-20-2N/A1-1N/A
USC		3-12-11-02-1N/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Notre Dame		3-0N/AN/A2-0N/A
USC		4-0N/AN/A3-0N/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Oct 11thNCSTW 36-7-23.5 WU 59.5ND -2400
Oct 4thBOISEW 28-7-21.5 LU 63ND -1600
Sep 27th@ARKW 56-13-5.5 WO 63.5ND -218
Sep 20thPURW 56-30-24.5 WO 51ND -4000
Sep 13thTA&ML 40-41-6.5 LO 49.5TA&M -250
Team Stats

Total

361
Total Yards
407
58
Total Plays
57
6.224137931034483
Yards Per Play
7.140350877192983

Passing

302
YDS
136
19/33
Comps/Atts
16/25
9.151515151515152
YPA
5.44
2/1
TDs/INTs
1/1
1/2
Sacks/Yards
1/9

Rushing

59
Rush Yards
271
25
Attempts
32
2.36
YPC
8.46875
0
TDs
2

Turnovers

1
Fumbles Lost
0
1
Interceptions
1

Efficiency

2/3 66.67%
Redzone
3/5 60%
4/10 0%
3rd Down
2/9 0%
0/1 0%
4th Down
1/1 0%

First Downs

21
Total
20
12
Pass
6
3
Rush
14
6
Penalty
0

Misc

1/5
Penalties/Yards
8/96

USC vs. Notre Dame Odds Comparison

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See more NCAAF Odds Right Arrow

USC at Notre Dame Team Totals

MatchupOverUnder
USC
4-0
N/A
N/A
Notre Dame
3-0
N/A
N/A