Astros vs. Orioles Odds & Betting Predictions - August 21, 2025
Astros at Orioles
11:15 pm • FOXStarting Pitchers
pitcher | team | era | w-l | |
---|---|---|---|---|
![]() | ![]() | 5.68 | 1-6 | |
![]() | ![]() | 2.63 | 3-1 |
Astros at Orioles Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
---|---|---|---|---|
![]() Astros 69-58 | -1.5 | -1.5+160 | o8.5-120 | -101 |
![]() Orioles 59-67 | u8.5 | +1.5-191 | u8.5-102 | -118 |

Oriole Park at Camden YardsBaltimore
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Astros vs. Orioles Expert Picks

Grant Neiffer
Last 30d: 32-99-2 (+14.4u)
Y.Diaz o0.5 HR+875
0.5u
C.Walker o0.5 HR+650
0.5u
J.Altuve o0.5 HR+900
0.5u

Sean Zerillo
Last 30d: 152-171-4 (-0.8u)
Under 9-108
0.54u
Bet to -125 or 8.5 (-105)
Astros vs. Orioles Previews & Analysis
Prop Odds Comparison
Line Movement Tracker
Astros vs. Orioles Public Betting Percentages
Betting Trends
- Orioles are 4-1 in their last 5 games.
- Orioles are 5-0 in their last 5 games against the spread
- Orioles are 33-33 in their road games against the spread
- The totals have gone OVER in 3 of Orioles' last 5 games
- The totals have gone OVER in 30 of Orioles' 60 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
Astros vs. Orioles Injury Updates

Astros Injuries
- Jake MeyersCF
Meyers is out with calf
Out
- Luis GarciaSP
Garcia is out with elbow
Out
- Pedro LeonRF
Leon is out with knee
Out
- J.P. FranceSP
France is out with shoulder
Out
- Hayden WesneskiRP
Wesneski is out with elbow
Out

Orioles Injuries
- Albert SuarezRP
Suarez is out with shoulder
Out
- Jorge MateoSS
Mateo is out with hamstring
Out
- Kyle BradishSP
Bradish is out with elbow
Out
- Grayson RodriguezSP
Rodriguez is out with elbow
Out
- Tyler WellsSP
Wells is out with elbow
Out
Astros vs. Orioles Starting Lineups

PITCHER | W-L | ERA | WHIP | K/9 | |
---|---|---|---|---|---|
![]() | 3-1 | 2.63 | 1.089 | 7.16 |
HITTERS | AVG | OBP | SLG | HR |
---|---|---|---|---|
![]() | .310 | .368 | .479 | 13 |
![]() | .267 | .319 | .386 | 7 |
![]() | .276 | .340 | .459 | 22 |
![]() | .150 | .203 | .233 | 0 |
![]() | .233 | .301 | .387 | 16 |
![]() | .256 | .315 | .404 | 10 |
![]() | .255 | .284 | .414 | 17 |
![]() | .246 | .315 | .363 | 7 |
![]() | .170 | .228 | .208 | 0 |

PITCHER | W-L | ERA | WHIP | K/9 | |
---|---|---|---|---|---|
![]() | 1-6 | 5.67 | 1.490 | 7.91 |
HITTERS | AVG | OBP | SLG | HR |
---|---|---|---|---|
![]() | .248 | .306 | .389 | 15 |
![]() | .276 | .326 | .473 | 15 |
![]() | .281 | .353 | .470 | 15 |
![]() | .227 | .310 | .373 | 9 |
![]() | .210 | .278 | .390 | 9 |
![]() | .300 | .364 | .400 | 0 |
![]() | .204 | .277 | .357 | 5 |
![]() | .286 | .444 | .357 | 0 |
![]() | .203 | .257 | .345 | 6 |
Astros vs. Orioles Odds Comparison
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Astros at Orioles Team Totals
MatchupOverUnder | ||
---|---|---|
![]() Astros 69-58 | N/A | N/A |
![]() Orioles 59-67 | N/A | N/A |