Astros vs. Orioles Odds & Betting Predictions - August 21, 2025

Astros at Orioles

11:15 pm • FOX
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Starting Pitchers
pitcherteameraw-l
Brandon Young logoB.YoungBaltimore Orioles logo5.681-6
Jason Alexander logoJ.AlexanderHouston Astros logo2.633-1

Astros at Orioles Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
69-58
-1.5
-1.5+160
o8.5-120
-101
Orioles
59-67
u8.5
+1.5-191
u8.5-102
-118
location pinThursday 11:15 p.m.
August 21, 2025
Oriole Park at Camden YardsBaltimore
thermometer image73°Fahrenheit
rain image0%Rain
wind image7Wind
Astros vs. Orioles Expert Picks
Grant Neiffer
Grant Neiffer
Last 30d: 32-99-2 (+14.4u)
Y.Diaz o0.5 HR+875
0.5u
C.Walker o0.5 HR+650
0.5u
J.Altuve o0.5 HR+900
0.5u
Sean Zerillo
Sean Zerillo
Last 30d: 152-171-4 (-0.8u)
Under 9-108
0.54u
Bet to -125 or 8.5 (-105)

Astros vs. Orioles Previews & Analysis

  • Astros vs Orioles: +120 SGP for Thursday article feature image

    Astros vs Orioles: +120 SGP for Thursday

    Alex Hinton
    Aug 21, 2025 UTC
  • Thursday's MLB Best Bets article feature image

    Thursday's MLB Best Bets

    Action Network Staff
    Aug 21, 2025 UTC
  • Zerillo's Opening Pitch for Thursday article feature image

    Zerillo's Opening Pitch for Thursday

    Sean Zerillo
    Aug 21, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Orioles Public Betting Percentages

Away Logo

Astros

Public

62%

Bets%

38%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Orioles
60-6627-3333-3320-3638-30
Astros
63-6430-3533-2934-5129-11

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Orioles
53-69-430-28-223-41-228-26-224-42-2
Astros
58-63-629-35-129-28-540-43-216-20-4

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Orioles
59-6730-3029-3725-3132-36
Astros
69-5838-2731-3146-3923-17

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 19th@BOSW 4-3+1.5 WU 9.5BAL +125
Aug 18th@BOSW 6-3-1.5 WO 8BAL +105
Aug 17th@HOUW 12-0-1.5 WO 8.5BAL -101
Aug 16th@HOUL 4-5+1.5 WO 8.5HOU +118
Aug 16th@HOUW 7-0+1.5 WU 7.5BAL +184

Astros vs. Orioles Injury Updates

Astros Injuries

  • Jake Meyers
    CF

    Meyers is out with calf

    Out

  • Luis Garcia
    SP

    Garcia is out with elbow

    Out

  • Pedro Leon
    RF

    Leon is out with knee

    Out

  • J.P. France
    SP

    France is out with shoulder

    Out

  • Hayden Wesneski
    RP

    Wesneski is out with elbow

    Out

Orioles Injuries

  • Albert Suarez
    RP

    Suarez is out with shoulder

    Out

  • Jorge Mateo
    SS

    Mateo is out with hamstring

    Out

  • Kyle Bradish
    SP

    Bradish is out with elbow

    Out

  • Grayson Rodriguez
    SP

    Rodriguez is out with elbow

    Out

  • Tyler Wells
    SP

    Wells is out with elbow

    Out

Astros vs. Orioles Starting Lineups
Astros Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Jason Alexander logoRJ.Alexander, P3-12.631.0897.16
HITTERSAVGOBPSLGHR
Jeremy Pena logo1J.Pena, SS.310.368.47913
Carlos Correa logo2C.Correa, 3B.267.319.3867
Jose Altuve logo3J.Altuve, 2B.276.340.45922
Jesus Sanchez logo4J.Sanchez, LF.150.203.2330
Christian Walker logo5C.Walker, 1B.233.301.38716
Victor Caratini logo6V.Caratini, C.256.315.40410
Yainer Diaz logo7Y.Diaz, DH.255.284.41417
Cam Smith logo8C.Smith, RF.246.315.3637
Jacob Melton logo9J.Melton, CF.170.228.2080
Orioles Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Brandon Young logoRB.Young, P1-65.671.4907.91
HITTERSAVGOBPSLGHR
Jackson Holliday logo1J.Holliday, 2B.248.306.38915
Jordan Westburg logo2J.Westburg, 3B.276.326.47315
Gunnar Henderson logo3G.Henderson, SS.281.353.47015
Adley Rutschman logo4A.Rutschman, DH.227.310.3739
Colton Cowser logo5C.Cowser, CF.210.278.3909
Samuel Basallo logo6S.Basallo, C.300.364.4000
Coby Mayo logo7C.Mayo, 1B.204.277.3575
Dylan Beavers logo8D.Beavers, RF.286.444.3570
Dylan Carlson logo9D.Carlson, LF.203.257.3456

Astros vs. Orioles Odds Comparison

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Astros at Orioles Team Totals

MatchupOverUnder
Astros
69-58
N/A
N/A
Orioles
59-67
N/A
N/A