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Astros vs. Guardians Odds & Betting Predictions - June 6, 2025

Astros at Guardians

11:10 pm • CLEG
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Houston Astros

34-28
@

Cleveland Guardians

33-28
Starting Pitchers
pitcherteameraw-l
Logan Allen logoL.AllenCleveland Guardians logo0.000-0
Colton Gordon logoC.GordonHouston Astros logo0.000-0

Astros at Guardians Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
34-28
+1.5
-1.5+135
o8.5-105
-130
Guardians
33-28
u8.5
+1.5-160
u8.5-115
+110
location pinFriday 11:10 p.m.
June 06, 2025
Progressive FieldCleveland
thermometer image66°Fahrenheit
rain image0%Rain
wind image6Wind
Astros vs. Guardians Expert Picks
Derek Carty
Derek Carty
Last 30d: 1-3-0 (-0.6u)
Jose Ramirez o0.5 Walks+260
1u
Payoff Pitch: https://myaction.app/X5dMrBQZYTb
Jim Sannes
Jim Sannes
Last 30d: 33-50-0 (+1.1u)
C.Gordon o4.5 Ks+116
1u
Have him projected at 5.12. Won't go deep in games, but he doesn't walk batters, which increases his pitch efficiency, and he gets a boost from a Guardians team that has struggled with strikeouts against lefties this year.
Sean Zerillo
Sean Zerillo
Last 30d: 135-141-6 (-3.5u)
HOU -105 (F5)
0.26u
Small to -120
HOU +105
0.5u
Bet to -104

Astros vs. Guardians Previews & Analysis

  • +630, +875 Home Run Picks Worth Betting article feature image

    +630, +875 Home Run Picks Worth Betting

    Action AI•
    Jun 6, 2025 UTC
  • Astros vs Guardians: Target This Side of Total article feature image

    Astros vs Guardians: Target This Side of Total

    Action Network Staff•
    Jun 6, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Guardians Public Betting Percentages

Away Logo

Astros

Public

Home Logo

Guardians

47%

Bets%

53%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Guardians are 3-2 in their last 5 games.
  • Guardians are 4-1 in their last 5 games against the spread
  • Guardians are 16-17 in their road games against the spread
  • The totals have gone OVER in 1 of Guardians' last 5 games
  • The totals have gone OVER in 12 of Guardians' 28 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Guardians		30-3114-1416-1711-1119-19
Astros		33-2918-1615-1318-2415-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Guardians		26-32-312-15-114-17-212-1014-21-3
Astros		25-35-214-2011-15-221-213-14-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Guardians		33-2817-1116-1715-718-20
Astros		34-2822-1212-1623-1911-8

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 5th@NYYL 0-4+1.5 LU 8.5NYY +225
Jun 4th@NYYW 4-0+1.5 WU 9CLE +164
Jun 3rd@NYYL 2-3+1.5 WU 8NYY +166
Jun 1stLAAW 4-2-1.5 WU 8CLE -210
May 31stLAAW 7-5-1.5 WO 8CLE -169

Guardians vs. Astros Injury Updates

Guardians Injuries

  • Ben Lively
    P

    Lively is out with elbow

    Out

  • Shane Bieber
    P

    Bieber is out with elbow

    Out

  • John Means
    P

    Means is out with elbow

    Out

Astros Injuries

  • Taylor Trammell
    OF

    Trammell is out with calf

    Out

  • Cristian Javier
    P

    Javier is out with elbow

    Out

  • Luis Garcia
    P

    Garcia is out with elbow

    Out

  • Pedro Leon
    OF

    Leon is out with knee

    Out

  • J.P. France
    P

    France is out with shoulder

    Out

  • Hayden Wesneski
    P

    Wesneski is out with elbow

    Out

  • Spencer Arrighetti
    P

    Arrighetti is out with thumb

    Out

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Astros vs. Guardians Odds Comparison

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Astros at Guardians Team Totals

MatchupOverUnder
Astros
34-28
N/A
N/A
Guardians
33-28
N/A
N/A