Astros vs. Pirates Odds & Betting Predictions - June 5, 2025

Astros at Pirates

10:40 pm • SCHN
8 - 2
Starting Pitchers
pitcherteameraw-l
Mitch Keller logoM.KellerPittsburgh Pirates logo3.731-7
Framber Valdez logoF.ValdezHouston Astros logo3.125-4

Astros at Pirates Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Astros
33-28
-1.5
-1.5+120
o7.5+101
-141
Pirates
23-39
u7.5
+1.5-140
u7.5-120
+120
location pinThursday 10:40 p.m.
June 05, 2025
PNC ParkPittsburgh
Astros vs. Pirates Expert Picks
Cam Is Money
Cam Is Money
Last 30d: 106-135-3 (-22.8u)
HOU -115 (Live)
0.43u
YBB SportsData
YBB SportsData
Last 30d: 9-6-0 (+3.3u)
HOU -145
1u
SDQL SYSTEM (60-44 Record) #YourBestBet
Scott Rickenbach
Scott Rickenbach
Last 30d: 78-75-2 (-9.9u)
HOU -149
0.67u
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 137-157-3 (-2.0u)
HOU -145
1u
Fade dogs off a home shutout win Overall: 210-87-0,71% (ROI:22%) Season:9-3-0,75% (ROI:32%) away favs off a shutout Overall: 125-58-0,68% (ROI:18%) Season:8-1-0,89% (ROI:57%)
The Degenerates
The Degenerates
Last 30d: 66-72-2 (-18.7u)
Under 7.5-114
1.14u
Picks Office
Picks Office
Last 30d: 77-73-0 (+3.2u)
PIT +135
1u
Follow @PicksOffice on X. Framber's road ERA jumps to 4.14 – not the same guy outside Houston. Pirates just shut out the Astros, held them to .212 avg. Mitch Keller has a 3.43 ERA in night games – 5 quality starts in May, just no run support. Momentum shift favors PIT at home. Astros averaging 3.8 runs/game on the road – bottom-tier offense outside Minute Maid. Pirates’ bullpen dialed in – 2.89 ERA over last 3 games. Keller’s 2.50 ERA over his last 3 starts shows he’s keeping games tight. PNC Park = pitcher-friendly, helps suppress big innings. Pirates better at home (14-17) than road (9-22). Houston just 11-15 away. Back-to-back 3-0 games this series – PIT proven they can shut the door. .
Under 7.5+100
1u
Follow @PicksOffice on X. Back-to-back 3-0 finals to open the series. Total of just 6 runs in 2 games. Both offenses ice cold – and tonight lines up for another pitcher's duel. Under 7.5 is the sharp look. Pittsburgh’s bats rank dead last in MLB. Houston averages just 3.8 runs on the road. Valdez: 2.05 ERA over his last 3 starts, but 4.14 ERA away from home. Keller: 2.50 ERA over his last 3 with solid night-game splits (3.43 ERA). Bullpens both sharp – Pirates relievers post a 2.89 ERA over their last 3. PNC Park also suppresses scoring with its pitcher-friendly layout. Under is 11-3 in PIT's last 14 home games, 8-2 in HOU’s last 10 interleague, and 19-7 in PIT's last 26 overall.
Jim Sannes
Jim Sannes
Last 30d: 33-50-0 (+1.1u)
F.Valdez o6.5 Ks+124
1.24u
In the alt market on FanDuel. Have Valdez projected for more than seven strikeouts due to his length, efficiency, and matchup. Would just check the weather in Pittsburgh before betting it to ensure the forecast hasn't gotten worse from what it looked like this morning.
Brian Bitler
Brian Bitler
Last 30d: 90-84-0 (+17.7u)
PIT +135
3u
CeeJ Picks
CeeJ Picks
Last 30d: 27-18-0 (+16.4u)
F.Valdez o5.5 Ks-125
1u
Taken on Novig Ridiculous value here for Valdez, who has been on an absolute tear and gets a top 4 K-target in the Pirates. This line is -160 and up on almost every other book, which is why a betting exchange like Novig is HUGE to snipe value like this. Framber is over this line in 7/12 games on the year, but over his last 6 games, he has caught fire. He has gone 21+ innings in 4/L5 games and just went 27 innings last game vs another top K target, the Rays. He has racked up 6+ Ks in 5/L6 games with his 1 miss being 5 Ks vs SEA. The Pirates rank 4th in K% on the season vs LHP, and over the last month, they rank 2nd. LHP vs the Pirates have gone over their K props at an astonishing 85%! That's insane. Only 2 LHP pitchers out of 13 haven't gone over their K line against this team. Framber's last meeting with the Pirates was last season when he struck out 10, and with much of the roster back this year, I expect Framber to have no problem with this lineup yet again. This is also a potential spot I would ladder or toss in a Ks lotto.
Boomer Betz
Boomer Betz
Last 30d: 112-149-0 (-29.4u)
F.Valdez u5.5 Hits Allowed-132
1.29u
M.Keller u2.5 Earned Runs-105
1.4u
Sean Zerillo
Sean Zerillo
Last 30d: 135-141-6 (-3.5u)
PIT +138
0.5u
Bet to +125

Astros vs. Pirates Previews & Analysis

  • Zerillo's Opening Pitch For Thursday article feature image

    Zerillo's Opening Pitch For Thursday

    Sean Zerillo
    Jun 5, 2025 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Astros vs. Pirates Public Betting Percentages

Away Logo

Astros

Public

82%

Bets%

18%

Money%

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Pirates
28-3515-1713-184-1424-21
Astros
33-2918-1615-1318-2415-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Pirates
24-35-414-16-210-19-27-1117-24-4
Astros
25-35-214-2011-15-221-213-14-2

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Pirates
23-4014-189-226-1217-28
Astros
34-2822-1212-1623-1911-8

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jun 4thHOUW 3-0+1.5 WU 9PIT +110
Jun 3rdHOUL 0-3-1.5 LU 7HOU -162
Jun 1st@SDL 4-6+1.5 LO 8.5SD +127
Jun 1st@SDW 5-0+1.5 WU 7.5PIT +191
May 31st@SDL 2-3+1.5 WU 7.5SD +160

Astros vs. Pirates Injury Updates

Astros Injuries

  • Taylor Trammell
    LF

    Trammell is out with calf

    Out

  • Cristian Javier
    SP

    Javier is out with elbow

    Out

  • Luis Garcia
    SP

    Garcia is out with elbow

    Out

  • Pedro Leon
    RF

    Leon is out with knee

    Out

  • J.P. France
    SP

    France is out with shoulder

    Out

  • Hayden Wesneski
    RP

    Wesneski is out with elbow

    Out

  • Spencer Arrighetti
    SP

    Arrighetti is out with thumb

    Out

Pirates Injuries

  • Johan Oviedo
    SP

    Oviedo is questionable with elbow

    Questionable

  • Jared Jones
    SP

    Jones is out with elbow

    Out

  • Jared Triolo
    SS

    Triolo is questionable with back

    Questionable

  • Spencer Horwitz
    1B

    Horwitz is questionable with wrist

    Questionable

Astros vs. Pirates Box Score
Astros Player Stats
Projected
PITCHERPCIPKER
Framber Valdez logoLF.Valdez, P997112
Bryan Abreu logoRB.Abreu, P15130
Kaleb Ort logoRK.Ort, P18120
HITTERSH-ABRHRRBI
Jeremy Pena logo1J.Pena, SS3-5201
Isaac Paredes logo2I.Paredes, 3B2-4223
Jose Altuve logo3J.Altuve, DH1-4001
Christian Walker logo4C.Walker, 1B1-4100
Yainer Diaz logo5Y.Diaz, C0-4000
Jake Meyers logo6J.Meyers, CF0-3100
Cam Smith logo7C.Smith, RF1-4101
Jacob Melton logo8J.Melton, LF2-4102
Mauricio Dubon logo9M.Dubon, 2B0-4000
Pirates Player Stats
Projected
PITCHERPCIPKER
Mitch Keller logoRM.Keller, P896.156
Kyle Nicolas logoRK.Nicolas, P191.210
Ryan Borucki logoLR.Borucki, P20112
HITTERSH-ABRHRRBI
Oneil Cruz logo1O.Cruz, CF1-4002
Andrew McCutchen logo2A.McCutchen, DH0-4000
Bryan Reynolds logo3B.Reynolds, RF0-3000
Nick Gonzales logo4N.Gonzales, 2B0-4000
Ke'Bryan Hayes logo5K.Hayes, 3B1-4000
Tommy Pham logo6T.Pham, LF0-2000
Henry Davis logo7H.Davis, C0-4000
Jared Triolo logo8J.Triolo, 1B2-2200
Spencer Horwitz logo8S.Horwitz, PH0-1000
Isiah Kiner-Falefa logo9I.Kiner-Falefa, SS1-4000

Astros vs. Pirates Odds Comparison

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Astros at Pirates Team Totals

MatchupOverUnder
Astros
33-28
N/A
N/A
Pirates
23-39
N/A
N/A