Turn your sports knowledge into winning predictions
21+ or 18+ in Certain Locations. 19+ in ON. Please Play Responsibly. Gambling Problem? Call 1-800-GAMBLER. Visit connexontario.ca or Call 1-866-531-2600 in ON.
No Code Needed

Michigan St vs. USC Odds & Betting Predictions - September 21, 2025

Michigan St at USC

3:00 am • FOX

Michigan State Spartans

3-1
31
31 - 45

USC Trojans

4-0
45

Michigan St at USC Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Michigan St
3-1
+14.5
+18.5-114
o55.5-110
+625
USC
4-0
u56.5
-18.5-106
u55.5-110
-950
location pinSunday 3:00 a.m.
September 21, 2025
Los Angeles Memorial ColiseumLos Angeles
Michigan St vs. USC Expert Picks
YBK Picks.com
Last 30d: 34-45-0 (-31.2u)
USC -19.5-105
3u
Will Brinson
Will Brinson
Last 30d: 41-32-0 (+8.4u)
USC -18.5-110
1.1u
Picks Office
Picks Office
Last 30d: 63-88-4 (-22.3u)
USC -18-110
1u
💰🦡 Jake
💰🦡 Jake
Last 30d: 96-112-7 (+35.5u)
MSU +10.5 (1H)+100
1u
Big Bets On Campus (CFB)
Big Bets On Campus (CFB)
Last 30d: 58-53-1 (+5.1u)
USC o36.5 Team Total-120
0.83u
@_Collin1 https://myaction.app/V2FMmqguNWb
USC -10 (1H)-110
0.91u
@Stuckey2 https://myaction.app/V2FMmqguNWb
Collin Wilson
Collin Wilson
Last 30d: 86-54-5 (+22.0u)
USC o37.5 Team Total-114
1u
Massive EPA edge to USC offense, also top 10 Quality and Finishing Drives.
Boomer Betz
Boomer Betz
Last 30d: 125-103-1 (+41.3u)
MSU +17.5-102
0.98u

Michigan St vs. USC Previews & Analysis

  • Michigan State vs. USC: Target Saturday's Total article feature image

    Michigan State vs. USC: Target Saturday's Total

    Mike McNamara•
    Sep 20, 2025 UTC
  • Your Week 4 NCAAF Betting Cheat Sheet article feature image

    Your Week 4 NCAAF Betting Cheat Sheet

    Pete Ruden•
    Sep 20, 2025 UTC
  • College Football Week 4 Best Bets & Player Props! | Big Bets On Campus LIVE! article feature image

    College Football Week 4 Best Bets & Player Props! | Big Bets On Campus LIVE!

    •
    Sep 19, 2025 UTC
  • Auburn vs Oklahoma BEST BETS! | College Football Best Bets & Preview | BBOC article feature image

    Auburn vs Oklahoma BEST BETS! | College Football Best Bets & Preview | BBOC

    Stuckey•
    Sep 19, 2025 UTC
See more NCAAF Coverage Right Arrow

Prop Odds Comparison

Right Arrow
Right Arrow

No props found

Line Movement Tracker

Right Arrow
Right Arrow

Michigan St vs. USC Public Betting Percentages

Away Logo

Michigan St

Public

Home Logo

USC

96%

Bets%

4%

Money%

NCAAF Public Betting Right Arrow

Betting Trends

  • USC are 4-0 in their last 5 games.
  • USC are 2-2 in their last 5 games against the spread
  • USC are 0-1 in their road games against the spread
  • The totals have gone OVER in 3 of USC' last 4 games
  • The totals have gone OVER in 3 of USC' 3 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
USC		2-22-10-12-2N/A
Michigan St		1-30-31-00-31-0

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
USC		3-13-00-13-1N/A
Michigan St		3-12-11-02-11-0

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
USC		4-0N/AN/A4-0N/A
Michigan St		3-1N/AN/A3-00-1

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Sep 13th@PURW 33-17-20.5 LU 59.5USC -1600
Sep 6thGASOW 59-20-29 WO 62.5USC -7000
Aug 30thMOSTW 73-13-36.5 WO 60USC -9000
Dec 28thTA&MW 35-31---
Nov 30thNDL 35-49+7 LO 52.5ND +207
Team Stats

Total

337
Total Yards
523
55
Total Plays
66
6.127272727272727
Yards Per Play
7.924242424242424

Passing

225
YDS
234
13/23
Comps/Atts
20/26
9.782608695652174
YPA
9
3/0
TDs/INTs
3/0
2/7
Sacks/Yards
0/0

Rushing

112
Rush Yards
289
32
Attempts
40
3.5
YPC
7.225
1
TDs
3

Turnovers

0
Fumbles Lost
1
0
Interceptions
0

Efficiency

2/3 66.67%
Redzone
6/6 100%
5/11 0%
3rd Down
8/12 0%
0/1 0%
4th Down
1/2 0%

First Downs

19
Total
27
7
Pass
11
8
Rush
13
4
Penalty
3

Misc

6/54
Penalties/Yards
9/78

Michigan St vs. USC Odds Comparison

Right Arrow

Could not load odds

See more NCAAF Odds Right Arrow

Michigan St at USC Team Totals

MatchupOverUnder
Michigan St
3-1
o18.5-113
u18.5-112
USC
4-0
o37.5-116
u37.5-114