Sweet 16 Betting Odds: Point Spreads, Over/Unders for All 8 NCAA Tournament Games

The first weekend of the NCAA Tournament is in the books, which means it's about time to start looking ahead to second weekend and the Sweet 16.

All lines have opened, and each has a point spread in single digits. Favorites going 16-0 straight-up in the second round has created more competitive matchups.

Find opening odds below, and see Sean Koerner's projected spreads FREE in The Action Network app.

NCAA Tournament Sweet 16 Betting Odds

#1 Duke vs. #4 Virginia Tech NCAA Tournament Betting Odds

• Spread: Duke -7.5
• Over/Under: 146.5
• Date: Friday, March 29
• Time: 9:39 p.m. ET
• Location: Washington D.C.
• TV: CBS

#1 Gonzaga vs. #4 Florida State NCAA Tournament Betting Odds

• Spread: Gonzaga -7
• Over/Under: 148
• Date: Thursday, March 28
• Time: 7:09 p.m. ET
• Location: Anaheim, Calif.
• TV: CBS

#2 Michigan State vs. #3 LSU NCAA Tournament Betting Odds

• Spread: Michigan State -6
• Over/Under: 149
• Date: Friday, March 29
• Time: 7:09 p.m. ET
• Location: Washington D.C.
• TV: CBS

#2 Tennessee vs. #3 Purdue NCAA Tournament Betting Odds

• Spread: Tennessee -1
• Over/Under: 146.5
• Date: Thursday, March 28
• Time: 7:29 p.m. ET
• Location: Louisville, Ky.
• TV: TBS

#1 North Carolina vs. #5 Auburn NCAA Tournament Betting Odds

• Spread: UNC -5
• Over/Under: 159.5
• Date: Friday, March 29
• Time: 7:29 p.m. ET
• Location: Kansas City, Mo.
• TV: TBS

#2 Michigan vs. #3 Texas Tech NCAA Tournament Betting Odds

• Spread: Michigan -2
• Over/Under: 126
• Date: Friday, March 29
• Time: 9:59 p.m. ET
• Location: Anaheim, Calif.
• TV: TBS

#2 Kentucky vs. #3 Houston NCAA Tournament Betting Odds

• Spread: Kentucky -3
• Over/Under: 136
• Date: Friday, March 29
• Time: 9:59 p.m. ET
• Location: Kansas City, Mo.
• TV: TBS

#1 Virginia vs. #12 Oregon NCAA Tournament Betting Odds

• Spread: Virginia -7.5
• Over/Under: 118.5
• Date: Thursday, March 28
• Time: 9:59 p.m. ET
• Location: Louisville, Ky.
• TV: TBS

Sean Koerner's Projected Spreads

Get point spreads for this game and every possible tournament matchup with our bracket simulator built by Sean Koerner, our Director of Predictive Analytics, a former oddsmaker and FantasyPros' most accurate in-season fantasy football ranker from 2015-2017.

Duke-Virginia Tech

• Spread: Duke -11.5
• Total: 142
• Proj Score: Duke 77 | Virginia Tech 65.5
• Win Probability: Duke 87.7% | Virginia Tech 12.3%

Florida State-Gonzaga

• Spread: Gonzaga -7.5
• Total: 146.5
• Proj Score: Gonzaga 77 | Florida State 69.5
• Win Probability: Gonzaga 76.8% | Florida State 23.2%

Michigan State-LSU

• Spread: Michigan State -6.5
• Total: 147.5
• Proj Score: Michigan State 77 | LSU 70.5
• Win Probability: Michigan State 73.3% | LSU 26.7%

Tennessee-Purdue

• Spread: Tennessee -1.5
• Total: 145.5
• Proj Score: Tennessee 73.5 | Purdue 72
• Win Probability: Tennessee 53.1% | Purdue 46.9%

North Carolina-Auburn

• Spread: North Carolina -5.5
• Total: 151.5
• Proj Score: North Carolina 78.5 | Auburn 73
• Win Probability: North Carolina 70% | Auburn 30%

Michigan-Texas Tech

• Spread: Michigan -1.5
• Total: 121.5
• Proj Score: Michigan 61.5 | Texas Tech 60
• Win Probability: Michigan 53.1% | Texas Tech 46.9%

Kentucky-Houston

• Spread: Kentucky -7.5
• Total: 132.5
• Proj Score: Kentucky 70 | Houston 62.5
• Win Probability: Kentucky 76.8% | Houston 23.2%

Virginia-Oregon

• Spread: Virginia -11
• Total: 121.5
• Proj Score: Virginia 66.5 | Oregon 55.5
• Win Probability: Virginia 86.3% | Oregon 13.7%