 Alabama | Nimari Burnett | G | Out for season | Left Team | Burnett is out for season with left team | Jan 7 |
| Alabama | Keon Ellis | G | Questionable | Illness | Ellis is questionable with illness | Dec 2 |
 Arizona St | Kimani Lawrence | F | Out | Leg | Lawrence is out with leg | Mar 11 |
| Arizona St | Luther Muhammad | G | Out for season | Shoulder | Muhammad is out for season with shoulder | Feb 10 |
| Arizona St | Taeshon Cherry | F | Out | COVID Protocols | Cherry is out with covid protocols | Jan 9 |
| Arizona St | Josh Christopher | G | Out | Leg | G Josh Christopher (leg) is out Wednesday at USC | Feb 18 |
 Arizona | Bennedict Mathurin | G-F | Questionable | Ankle | Mathurin is questionable with ankle | Jan 26 |
 Arkansas | Chris Lykes | G | Out for season | Ankle | Lykes is out for season with ankle | Feb 27 |
| Arkansas | Khalen Robinson | G | Out for season | Foot | Robinson is out for season with foot | Jan 12 |
 Auburn | Sharife Cooper | G | Out | Ankle | Cooper is out with ankle | Mar 6 |
 BYU | Richard Harward | C | Questionable | Wrist | Harward is questionable with wrist | Jan 22 |
| BYU | Gavin Baxter | F | Out for season | Knee | Baxter is out for season with knee | Nov 29 |
 Boise State | Marcus Shaver Jr. | G | Questionable | Foot | Shaver is questionable with foot | Dec 22 |
| Boise State | Abu Kigab | F | Out for season | Shoulder | Kigab is out for season with shoulder | Mar 16 |
| Boise State | Max Rice | G | Out for season | Foot | Rice is out for season with foot | Mar 15 |
 Boston Col | Brevin Galloway | G | Out for season | Knee | G Brevin Galloway (knee) is out for the season | Jan 20 |
 Bowling Green | Matiss Kulackovskis | F | Out for season | Leg | Kulackovskis is out for season with leg | Jan 12 |
 Bradley | Ja'Shon Henry | F | Out | Foot | F Ja'Shon Henry (foot) is out Thursday vs. So Illinois | Mar 4 |
| Bradley | Ari Boya | F | Out for season | Foot | Boya is out for season with foot | Feb 26 |
| Bradley | Danya Kingsby | G | Out | Suspension | Kingsby is out with suspension | Feb 13 |
 Bryant U | Melo Eggleston | G | Out for season | Achilles | Eggleston is out for season with achilles | Dec 16 |
 Butler | Aaron Thompson | G | Out for season | Shoulder | G Aaron Thompson (shoulder) will miss remainder of the season | Mar 4 |
| Butler | Christian David | F | Out | Knee | David is out with knee | Feb 28 |
| Butler | Markeese Hastings | F | Out for season | Left Team | Hastings is out for season with left team | Feb 24 |
| Butler | JaKobe Coles | F | Out for season | Knee | Coles is out for season with knee | Jan 26 |
 Charlotte | Milos Supica | F | Out | Ankle | Supica is out with ankle | Feb 27 |
 Colorado | Evan Battey | F | Probable | Leg | Battey is probable with leg | Feb 8 |
 UConn | Matt Garry | G | Out for season | Knee | Garry is out for season with knee | Dec 4 |
 Creighton | Modestas Kancleris | F | Out for season | Knee | Kancleris is out for season with knee | Nov 10 |
| Creighton | Rati Andronikashvili | G | Out for season | Knee | Andronikashvili is out for season with knee | Nov 6 |
 Davidson | Foster Loyer | G | Out for season | Shoulder | Loyer is out for season with shoulder | Mar 3 |
 Dayton | Moulaye Sissoko | C | Out for season | Knee | Sissoko is out for season with knee | Feb 23 |
| Dayton | R.J. Blakney | F-G | Out | Undisclosed | Blakney is out with undisclosed | Mar 20 |
 Delaware | Jyare Davis | F | Questionable | Q for next game | Davis is questionable with concussion | Dec 5 |
 Drake | Noah Thomas | G | Out for season | Personal | Thomas is out for season with personal | Nov 25 |
| Drake | Roman Penn | G | Out for season | Foot | Penn is out for season with foot | Feb 23 |
 Duke | Jalen Johnson | F | Out for season | Personal | F Jalen Johnson (personal) opting out of remainder of season | Feb 16 |
 Duquesne | Sincere Carry | G | Out for season | Left Team | Carry is out for season with left team | Jan 12 |
 E. Carolina | Tyrie Jackson | G | Out for season | Ankle | Jackson is out for season with ankle | Feb 10 |
| E. Carolina | Wynston Tabbs | G | Out for season | Left Team | G Wynston Tabbs leaving Boston College; entering the transfer portal. | Feb 18 |
 Florida | Keyontae Johnson | F | Out for season | Medical | Johnson is out for season with medical | Dec 15 |
| Florida | CJ Felder | F | Doubtful | Undisclosed | Felder is doubtful with undisclosed | Feb 1 |
 FGCU | Andre Weir | F | Out for season | Left Team | Weir is out for season with left team | Dec 22 |
 Fordham | Antonio Daye Jr. | G | Out for season | Left Team | G Antonio Daye leaving Florida International; entering the transfer portal. | Feb 23 |
 Fresno State | Jemarl Baker Jr. | G | Out for season | Hand | Baker is out for season with hand | Jan 12 |
| Fresno State | Jordan Campbell | G | Out | Upper Body | Campbell is out with upper body | Feb 9 |
 George Mason | Ian Boyd | G | Out for season | Left Team | Boyd is out for season with left team | Feb 9 |
 G Washington | Ira Lee | F | Out for season | Left Team | Lee is out for season with left team | Mar 9 |
 Georgetown | Jalen Harris | G | Out | still away from team | Harris is out with personal | Jan 6 |
| Georgetown | Kobe Clark | F | Out | Ankle | Clark is out with ankle | Dec 11 |
 GA Tech | Moses Wright | F | Out | COVID Protocols | Wright is out with covid protocols | Mar 18 |
| GA Tech | Tristan Maxwell | G | Out | Foot | Maxwell is out with foot | Jan 19 |
 Grambling St | RJ Gladney | F | Out | Concussion | Gladney is out with concussion | Mar 13 |
 Grand Canyon | Aidan Igiehon | F | Out | Illness | Igiehon is out with illness | Feb 27 |
 Houston | Josh Carlton | F-C | Questionable | Ankle | Carlton is questionable with ankle | Mar 5 |
| Houston | Marcus Sasser | G | Questionable | Undisclosed | Sasser is questionable with undisclosed | Dec 21 |
 Howard | Nojel Eastern | G | Out for season | Personal | Eastern is out for season with personal | Jan 5 |
| Howard | Makur Maker | C | Out | Groin | Maker is out with groin | Nov 28 |
 Illinois | Austin Hutcherson | G | Out for season | Back | Hutcherson is out for season with back | Jan 2 |
| Illinois | Benjamin Bosmans-Verdonk | F | Questionable | Foot | Bosmans-Verdonk is questionable with foot | Nov 26 |
 Illinois St | Sy Chatman | F | Out for season | Personal | Chatman is out for season with personal | Jan 10 |
 Iowa State | Gabe Kalscheur | G | Out | Hand | Kalscheur is out with hand | Feb 18 |
| Iowa State | Tristan Enaruna | G-F | Out | Illness | Enaruna is out with illness | Mar 17 |
| Iowa State | Xavier Foster | F | Out for season | Foot | Foster is out for season with foot | Jan 11 |
 JMU | Matt Lewis | G | Out for season | Knee | G Matt Lewis (knee) will miss remainder of the season | Feb 26 |
 K State | Montavious Murphy | F | Out for season | Knee | Murphy is out for season with knee | Feb 24 |
 Kent State | Danny Pippen | F | Out | Undisclosed | Pippen is out with undisclosed | Mar 11 |
| Kent State | Andrew Garcia | G-F | Questionable | Leg | Garcia is questionable with leg | Mar 12 |
 Kentucky | Oscar Tshiebwe | F | Out for season | Left Team | Tshiebwe is out for season with left team | Jan 12 |
 LSU | Javonte Smart | G | Questionable | COVID Protocols | Smart is questionable with covid protocols | Dec 26 |
| LSU | Shareef O'Neal | F | Out for season | Foot | O'Neal is out for season with foot | Mar 4 |
| LSU | Seneca Knight | G | Out for season | Personal | Knight is out for season with personal | Dec 29 |
 LA Tech | Cobe Williams | G | Out | Finger | Williams is out with finger | Mar 12 |
| LA Tech | Jace Bass | G | Out for season | Left Team | Bass is out for season with left team | Jan 29 |
 LA-Lafayette | Trajan Wesley | G | Out for season | Foot | Wesley is out for season with foot | Feb 13 |
| LA-Lafayette | Durey Cadwell | G | Out for season | Knee | Cadwell is out for season with knee | Feb 13 |
| LA-Lafayette | Brayan Au | G | Out for season | Knee | Au is out for season with knee | Feb 15 |
 Louisville | Malik Williams | F-C | Out | Foot | Williams is out with foot | Mar 1 |
 Loyola Mary | Kodye Pugh | F | Out | Knee | Pugh is out with knee | Nov 29 |
| Loyola Mary | Dameone Douglas | G-F | Out for season | Undisclosed | G Dameane Douglas (undisclosed) will miss the remainder of the season | Jan 30 |
| Loyola Mary | Keli Leaupepe | F | Out | Foot | Leaupepe is out with foot | Mar 6 |
 UMASS | Rich Kelly | G | Out for season | Foot | Kelly is out for season with foot | Feb 25 |
| UMASS | Preston Santos | G-F | Out | Personal | Santos is out with personal | Dec 31 |
 Memphis | Isaiah Stokes | F | Out for season | Suspension | Stokes is out for season with suspension | Nov 19 |
| Memphis | Alex Lomax | G | Out | Ankle | Lomax is out with ankle | Mar 10 |
| Memphis | Earl Timberlake | G | Out for season | Shoulder | Timberlake is out for season with shoulder | Feb 16 |
 Miami (FL) | Rodney Miller Jr. | C | Out for season | Knee | Miller is out for season with knee | Dec 27 |
| Miami (FL) | Sam Waardenburg | F | Out for season | Foot | Waardenburg is out for season with foot | Oct 30 |
| Miami (FL) | Harlond Beverly | G | Out for season | Back | Beverly is out for season with back | Feb 27 |
 Michigan | Isaiah Livers | F | Out for season | Foot | Livers is out for season with foot | Mar 23 |
 Middle Tenn | Josh Jefferson | G | Out for season | Left Team | G Josh Jefferson leaving Wisc Green Bay; entering the transfer portal. | Feb 26 |
| Middle Tenn | Jayce Johnson | G-F | Out | Undisclosed | Johnson is out with undisclosed | Jan 9 |
 Mississippi St | Tolu Smith | F | Out | Undisclosed | F Tolu Smith (undisclosed) is out Thursday vs. Richmond | Mar 25 |
 Missouri | Jarron Coleman | G | Out | Undisclosed | Coleman is out with undisclosed | Nov 25 |
| Missouri | Amari Davis | G | Out for season | Left Team | G Amari Davis leaving Wisc Green Bay; entering the transfer portal. | Feb 26 |
 Morgan State | Myles Douglas | F | Out for season | Leg | Douglas is out for season with leg | Feb 20 |
| Morgan State | Keith McGee | G | Out for season | Personal | McGee is out for season with personal | Jan 13 |
 Navy | Cam Davis | G | Out | Contact Tracing | Davis is out with contact tracing | Feb 27 |
| Navy | Richard Njoku | F | Out | Contact Tracing | Njoku is out with contact tracing | Feb 27 |
 Nebraska | Akol Arop | F | Out for season | Knee | Arop is out for season with knee | Nov 12 |
 Nevada | AJ Bramah | G-F | Out for season | Left Team | G AJ Bramah leaving Robert Morris; entering the transfer portal. | Feb 12 |
 New Mexico | Rod Brown | F | Out | Undisclosed | Brown is out with undisclosed | Mar 4 |
| New Mexico | Gethro Muscadin | F | Out | Leg | Muscadin is out with leg | Mar 5 |
| New Mexico | Saquan Singleton | G | Questionable | Undisclosed | Singleton is questionable with undisclosed | Feb 17 |
| New Mexico | Valdir Manuel | F | Out | Undisclosed | Manuel is out with undisclosed | Mar 11 |
 N. Mexico St | Teddy Allen | G | Out for season | Left Team | Allen is out for season with left team | Mar 2 |
 NC State | Devon Daniels | G | Questionable | Leg | Daniels is questionable with leg | Jan 28 |
| NC State | Braxton Beverly | G | Out | Undisclosed | Beverly is out with undisclosed | Mar 25 |
| NC State | Thomas Allen | G | Out for season | Ankle | Allen is out for season with ankle | Mar 2 |
| NC State | Ebenezer Dowuona | F | Out | Undisclosed | Dowuona is out with undisclosed | Mar 25 |
 UNC | Justin McKoy | F | Out | Undisclosed | McKoy is out with undisclosed | Mar 20 |
 North Florida | Carter Hendricksen | F | Out | Foot | F Carter Hendricksen (foot) is out indefinitely | Dec 7 |
 North Texas | Jahmiah Simmons | F | Out for season | Achilles | Simmons is out for season with achilles | Oct 14 |
| North Texas | Rubin Jones | G | Out | Ankle | Jones is out with ankle | Mar 11 |
 Northeastern | Glen McClintock | G | Out | Undisclosed | McClintock is out with undisclosed | Feb 27 |
 N. Arizona | Jalen Cone | G | Out | Ankle | Cone is out with ankle | Feb 23 |
 N. Iowa | AJ Green | G | Out for season | Hip | Green is out for season with hip | Dec 13 |
| N. Iowa | Antwan Kimmons | G | Out | Personal | Kimmons is out with personal | Dec 5 |
 Ohio State | Abel Porter | G | Out for season | Medical | Porter is out for season with medical | Nov 4 |
| Ohio State | Joey Brunk | F | Out for season | Back | Brunk is out for season with back | Feb 23 |
| Ohio State | Kyle Young | F | Out | Concussion | F Kyle Young (concussion) is out Friday vs. Oral Roberts | Mar 19 |
| Ohio State | Jimmy Sotos | G | Out for season | Shoulder | Sotos is out for season with shoulder | Feb 3 |
 OK State | Donovan Williams | G | Out for season | Knee | Williams is out for season with knee | Jan 19 |
 Ole Miss | Devontae Shuler | G | Questionable | Personal | G Devontae Shuler (personal) is questionable Friday vs. Louisiana Tech | Mar 17 |
| Ole Miss | Tye Fagan | G | Questionable | Leg | Fagan is questionable with leg | Mar 12 |
 Oregon | De'Vion Harmon | G | Out | Illness | G De'Vion Harmon (illness) is out Saturday vs. Missouri | Mar 17 |
| Oregon | N'Faly Dante | C | Out for season | Knee | Dante is out for season with knee | Dec 19 |
 Pacific | Justin Moore | G | Doubtful | Ankle | Moore is doubtful with ankle | Mar 8 |
 Pepperdine | Keith Fisher III | F | Out for season | Personal | Fisher is out for season with personal | Nov 25 |
 Pittsburgh | John Hugley | F | Out | Suspension | Hugley is out with suspension | Jan 15 |
 Portland State | Michael Carter III | G | Out for season | Dismissed | Carter is out for season with dismissed | Mar 7 |
| Portland State | Marlon Ruffin | G-F | Out | Head | Ruffin is out with head | Feb 8 |
 Rhode Island | Jeremy Sheppard | G | Out | Ankle | Sheppard is out with ankle | Mar 2 |
| Rhode Island | Allen Betrand | G | Out for season | Knee | Betrand is out for season with knee | Mar 6 |
| Rhode Island | Makhi Mitchell | C | Out for season | Knee | Mitchell is out for season with knee | Dec 17 |
 Richmond | Grant Golden | F | Out | Finger | C Grant Golden (finger) is out Wednesday vs. Toledo | Mar 17 |
| Richmond | Blake Francis | G | Out | Hip | G Blake Francis (hip) is out Thursday vs. Mississippi St | Mar 25 |
| Richmond | Connor Crabtree | G | Out | Foot | Crabtree is out with foot | Dec 30 |
 Robert Morris | Ferron Flavors Jr. | G | Probable | Finger | Flavors is probable with finger | Feb 3 |
 Hawks | Gabe Brown | C | Questionable | COVID Protocols | Brown is questionable with covid protocols | Feb 4 |
| Bearcats | Christopher Agbo | C | Out | Personal | Agbo is out with personal | Jan 29 |
 Saint Joe's | Dahmir Bishop | G | Questionable | Undisclosed | Bishop is questionable with undisclosed | Feb 25 |
 Saint Louis | Markhi Strickland | G-F | Out | COVID Protocols | Strickland is out with covid protocols | Feb 27 |
 San Diego State | Jaedon LeDee | F | Questionable | Undisclosed | LeDee is questionable with undisclosed | Dec 4 |
| San Diego State | Lamont Butler | G | Questionable | Calf | Butler is questionable with calf | Feb 25 |
| San Diego State | Keith Dinwiddie Jr. | G | Out | Undisclosed | Dinwiddie is out with undisclosed | Feb 23 |
 Santa Clara | Miguel Tomley | G | Out | Undisclosed | Tomley is out with undisclosed | Mar 6 |
 Seton Hall | Bryce Aiken | G | Out | Undisclosed | Aiken is out with undisclosed | Mar 11 |
| Seton Hall | Alexis Yetna | F | Out | Ankle | Yetna is out with ankle | Mar 11 |
 Siena | Nick Hopkins | G | Out | Leg | Hopkins is out with leg | Feb 21 |
| Siena | Harrison Curry | F | Out | Undisclosed | Curry is out with undisclosed | Mar 4 |
 S. Alabama | Lance Thomas | F | Out for season | Left Team | Thomas is out for season with left team | Jan 22 |
| S. Alabama | Diante Smith | F | Out for season | Left Team | Smith is out for season with left team | Dec 8 |
 S. Carolina | Alanzo Frink | F | Out for season | Medical | Frink is out for season with medical | Jan 26 |
 SE Missouri | Nate Johnson | C | Out for season | Leg | G Nate Johnson (leg) is out for the remainder of the season | Feb 27 |
 S. Illinois | Lance Jones | G | Out | Leg | Jones is out with leg | Mar 5 |
| S. Illinois | Marcus Domask | F | Out | Foot | Domask is out with foot | Feb 18 |
 SMU | Feron Hunt | F | Out | Ankle | F Feron Hunt (ankle) is out Thursday vs. Boise State | Mar 19 |
 Stanford | Ziaire Williams | F | Out | Personal | F Ziaire Williams (personal) is out for the Pac-12 Tournament | Mar 11 |
 Stony Brook | Anthony Roberts | G | Out for season | Left Team | Roberts is out for season with left team | Jan 26 |
 Syracuse | Bourama Sidibe | C | Out for season | Knee | Sidibe is out for season with knee | Feb 12 |
 TCU | Francisco Farabello | G | Out for season | Calf | Farabello is out for season with calf | Feb 19 |
 Tennessee | John Fulkerson | F | Out | Concussion | F John Fulkerson (concussion) is out Friday vs. Oregon State | Mar 19 |
| Tennessee | Justin Powell | G | Out for season | Left Team | Powell is out for season with left team | Mar 9 |
 UT Grande Valley | Sean Rhea | F | Out for season | Left Team | F Sean Rhea leaving Texas Rio Grande Valley; entering the transfer portal. | Feb 25 |
 Texas Tech | Kevin McCullar | G | Probable | Ankle | McCullar is probable with ankle | Dec 29 |
| Texas Tech | Daniel Batcho | F | Out | Knee | Batcho is out with knee | Nov 5 |
 Toledo | AJ Edu | F | Out for season | Knee | Edu is out for season with knee | Jan 19 |
 Towson | Terry Nolan Jr. | G | Out | Suspension | Nolan is out with suspension | Feb 13 |
 Troy | Kam Woods | G | Out for season | Left Team | Woods is out for season with left team | Mar 2 |
 UCSB | Zach Harvey | G | Out for season | Personal | Harvey is out for season with personal | Feb 17 |
 UCLA | Chris Smith | G | Out for season | Knee | Smith is out for season with knee | Jan 3 |
 UNLV | Marvin Coleman | G | Out for season | Leg | Coleman is out for season with leg | Jan 16 |
| UNLV | Donovan Williams | G | Out | Knee | Williams is out with knee | Mar 6 |
 UTEP | Eric Vila | F | Out for season | Foot | Vila is out for season with foot | Feb 12 |
 UTSA | Darius McNeill | G | Out | Undisclosed | McNeill is out with undisclosed | Mar 19 |
| UTSA | Luka Barisic | F | Out for season | Personal | Barisic is out for season with personal | Feb 13 |
 Utah | Gabe Madsen | G | Out for season | Personal | Madsen is out for season with personal | Dec 31 |
 Valparaiso | Connor Barrett | G-F | Out for season | Ankle | Barrett is out for season with ankle | Feb 16 |
 Vanderbilt | Liam Robbins | C | Out | Ankle | Robbins is out with ankle | Mar 10 |
| Vanderbilt | Tyrin Lawrence | G | Out for season | Knee | Lawrence is out for season with knee | Jan 19 |
 Villanova | Dhamir Cosby-Roundtree | F | Out | Leg | Cosby-Roundtree is out with leg | Nov 19 |
| Villanova | Collin Gillespie | G | Out for season | Knee | G Collin Gillespie (knee) will miss remainder of the season | Mar 4 |
 VCU | KeShawn Curry | G | Out | Personal | Curry is out with personal | Feb 23 |
| VCU | Jimmy Nichols Jr. | F | Out for season | Illness | Nichols is out for season with illness | Feb 11 |
| VCU | Jarren McAllister | G | Out for season | Knee | McAllister is out for season with knee | Dec 3 |
 VA Tech | Cartier Diarra | G | Out | Personal | Diarra is out with personal | Dec 16 |
 Wake Forest | Khadim Sy | F | Out for season | Personal | Sy is out for season with personal | Mar 4 |
| Wake Forest | Tariq Ingraham | F | Out for season | Illness | Ingraham is out for season with illness | Dec 22 |
 Washington St | TJ Bamba | G | Out | Undisclosed | Bamba is out with undisclosed | Mar 10 |
| Washington St | Andrej Jakimovski | F | Questionable | Groin | Jakimovski is questionable with groin | Feb 14 |
| Washington St | Jefferson Koulibaly | G | Out for season | Arm | Koulibaly is out for season with arm | Nov 12 |
 West Virginia | Isaiah Cottrell | F | Out for season | Achilles | Cottrell is out for season with achilles | Dec 30 |
 W. Kentucky | Jaylen Butz | F | Out for season | Left Team | Butz is out for season with left team | Jan 12 |
| W. Kentucky | Carson Williams | F | Out | Personal | Williams is out with personal | Mar 16 |
 Wyoming | Hunter Thompson | F | Probable | Ankle | Thompson is probable with ankle | Jan 16 |
 Xavier | Jack Nunge | F | Out for season | Knee | Nunge is out for season with knee | Feb 26 |
| Xavier | Ben Stanley | F | Questionable | Knee | Stanley is questionable with knee | Jan 7 |
| Xavier | Dieonte Miles | F | Out | Knee | Miles is out with knee | Feb 24 |