Clemson vs. Iowa State Betting Model Predictions, Picks: The Big Edge for Wednesday’s Cheez-It Bowl

Clemson vs. Iowa State Odds

*Odds updated Wednesday at 2 p.m. ET.

If you can consider a 9-3 season a disappointing one, then the Clemson Tigers have had a disappointing 2021 campaign to this point.

Clemson, a perennial national championship contender, failed to win the ACC Atlantic Division, meaning a trip the conference title game was not in the cards for Dabo Swinney's team.

On the other hand, the Tigers did circle the wagons after a 4-3 start to season by winning five straight games heading into Wednesday's Cheez-It Bowl against Iowa State.

Bettors have taken note and are riding Clemson's momentum in this game as 69% of spread tickets have come in on the Tigers.

But that doesn't mean it's the smartest play, either.

So what is the best bet for Clemson vs. Iowa State? Is it riding with the Tigers or are the Cyclone offering contrarian value.

Maybe it's not even the spread bettor should be targeting either?

Thanks to our College Football PRO Projections, we know that the answer lies in the single biggest edge remaining for the rest of the entire 2021-22 college football bowl season.

Let's detail the Clemson vs. Iowa State wager popping with value ahead of Wednesday's Cheez-It Bowl kickoff.

Clemson vs. Iowa State Prediction