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Clemson vs. LSU Odds, Picks, Betting Predictions: Will Burrow’s Tigers Cover Spread in National Title Game?

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Kevin Abele/Icon Sportswire via Getty Images. Pictured: Trevor Lawrence

  • Updated Clemson vs. LSU odds list Joe Burrow's Tigers as 4-point betting favorites over Trevor Lawrence's Tigers ahead of Monday's national championship game, which kicks off in just a few minutes.
  • Public bettors have been all over LSU for the last two weeks, but Clemson money showed up in a big way on Monday.
  • Get our experts' Clemson vs. LSU picks and predictions below, plus full breakdowns of every mismatch, live betting strategy and more.

Clemson vs. LSU Betting Odds, Picks

  • Odds: LSU -4.5 vs. Clemson
  • Total: 66.5
  • Moneyline: LSU -215, Clemson +170
  • Time: 8 p.m. ET
  • TV: ESPN
  • Location: New Orleans, La.

Two unbeaten teams. A Heisman winner leading an unstoppable offense against the defending national champions.

Does it get much better than this?

Clemson is looking to win a second straight national title and third in four years, but will have to limit LSU’s top-ranked offense and Heisman winner Joe Burrow on Monday night in New Orleans.

Who has the edge in the title game? Let’s dive in.


Clemson vs. LSU odds as of Sunday night and via FanDuel, where new users can get 150-1 odds on either moneyline in the national title game.


How Odds Have Moved for Clemson-LSU

Clemson was a 1.5-point favorite over LSU at FanDuel in lookahead lines before the semifinals, but that line disappeared quickly while LSU was blowing out Oklahoma.

Circa Sports in Las Vegas opened LSU -3.5 against either Clemson or Ohio State during halftime of LSU’s semifinal vs. Oklahoma, and it quickly went to -5.5. DraftKings got as high as LSU -6.5 that night, but came back to -5.5 by the next afternoon.

Since, this line has floated in a dead zone at -5.5 and did get down to -4.5 on Monday night thanks to some late sharp action.

LSU is getting 67% of the bets and 73% of the money, which would be high marks for any national title or semifinal game in the College Football Playoff era.

The total has dropped since the consensus opening of 69.5, with sharp action hitting the under this weekend. — Steve Petrella

When LSU Has the Ball

There’s not much more you can say about LSU’s offense. It’s the most dynamic passing attack in the country. It’s efficient and explosive. No one has been able to slow down the Tigers.

So Clemson defensive coordinator Brent Venables will need to effectively deploy versatile linebacker Isaiah Simmons to have a chance. The importance of Simmons cannot be understated, as the junior has 7 sacks, 14 tackles for loss, 3 interceptions and 60 solo tackles.

Venables can use Simmons to pressure Burrow, cover wide receiver Justin Jefferson or spy on running back Clyde Edwards-Helaire. Simmons has missed just four tackles all season and none in his last five games, and he lines up literally all over the field.

There are so many weapons for the LSU offense that it’s unlikely Clemson will know where to start through the first few drives of the game, and I think that will give LSU an early lead.

Eventually, Venables will figure out how to best use Simmons, which should result in Clemson’s defense improving as the game goes on (and that’s why I’m targeting a live bet on Clemson in the Middle 8 portion of the game).

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