Saturday NFL Betting Cheat Sheet: Odds, Picks & Predictions for Rams-49ers

Saturday NFL Betting Cheat Sheet: Odds, Picks & Predictions for Rams-49ers article feature image
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Rich Barnes-USA TODAY Sports. Pictured: Tom Brady, Jordan Phillips

  • Looking for betting odds and picks for Saturday's Week 16 NFL slate?
  • Our experts have you covered with how they're betting Texans at Buccaneers, Bills at Patriots and Rams at 49ers.
  • Our staff also analyzes the most important matchups of each game and reveal their own projected spreads to help you make the best bets.

Our crew has everything you need to bet Saturday’s trio of NFL games.

You’ll find our experts’ favorite bets, comprehensive guides for each matchup and more coverage below.


Odds as of Saturday morning and via DraftKings, where Action Network users get a risk-free bet up to $500.


Our Favorite NFL Betting Picks for Saturday

Our staff reveals how they’re betting Saturday’s slate, including picks against the spread and over/unders. Here are their four favorite bets.

NFL Betting Odds & Previews for Saturday

Our staff previews all three of Saturday’s games, complete with analysis of the biggest mismatches and more. You can read our guide to all three here or find individual previews below.

Rams at 49ers

  • Odds: 49ers -6.5
  • Over/Under: 44.5
  • Kickoff: 8:15 p.m. ET
  • TV Channel: NFL Network

This time in 2018, the Rams were marching toward an NFC championship while the 49ers were wrapping their fourth-straight losing season. Now Los Angeles is fighting for a slim chance at the conference’s final wild-card spot.

Our experts on where to find the betting value in this NFC West showdown.

Texans at Buccaneers

  • Odds: Texans -3.5
  • Over/Under: 50.5
  • Kickoff: 1 p.m. ET on Saturday
  • TV Channel: NFL Network

The public is all over Houston, with more than 80% of bettors backing the Texans to move them from 1-point underdogs to 3.5-point favorites. Our experts on whether you should follow the public’s lead.

Bills at Patriots

  • Odds: Patriots -6.5
  • Over/Under: 37
  • Kickoff: 4:30 p.m. ET
  • TV Channel: NFL Network

When these two teams met in Week 4, there were 26 total points scored — hence how this matchup earned the lowest over/under of Week 16. Our experts on how to bet this AFC East showdown.

NFL Sharp Betting Picks

Pro bettors are on all three of Saturday’s games. Find out how they’re betting each.

Pick ‘Em Confidence Ratings

Sean Koerner ranks against-the-spread and straight-up picks for pick ’em pools. Read how he stacks every team for Week 16.

Survivor Pool Strategy

Two. More. Weeks. If you’re still alive in survivor pools, we’ve got you covered with the best picks for Week 16.