Week 10 NFL Betting Cheat Sheet: Odds, Picks & Predictions

Week 10 NFL Betting Cheat Sheet: Odds, Picks & Predictions article feature image
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Kelley L Cox-USA TODAY Sports. Pictured: Jared Goff, Todd Gurley, Cooper Kupp

  • Find Week 10 NFL odds, expert picks and more for all of Sunday's games outlined below.
  • We also highlight the best prop bets, how pros are betting the slate and more.

Our crew has everything you need to bet Week 10 of the NFL season.

You’ll find our staff’s favorite bets, comprehensive guides for every game and much more below.


Odds as of Sunday morning and via PointsBet, where Action Network users can access an exclusive promotion to get a 200% deposit match (deposit $50, bet with $150).


Week 10 NFL Picks

Our staff reveals how they’re betting Sunday’s games, including picks against the spread and over/unders. See their favorite bets.

Week 10 NFL Odds & Previews for Every Game

Our analysts break down the most important angles of every matchup. You can read all 10 previews here or find individual games below.

1 ET Games

Giants (-3) at Jets: Should the G-Men really be field-goal favorites? Our experts break down this battle of New York.


Darren Rovell loves the Giants to cover against the Jets this week. PointsBet is giving everyone in New Jersey boosted odds to bet the other side — Jets +2.5 (+110).


Falcons at Saints (-14): Drew Brees and Co. are two-touchdown favorites in this NFC South showdown. Our analysts identify the best betting angle for this game.

Chiefs (-6) at Titans: Patrick Mahomes is back. Our experts on whether Kansas City is being properly valued with the return of its star QB.

Ravens (-10) at Bengals: Lamar Jackson and the Ravens are coming off their biggest win of the season. Our staff details whether to buy or fade them.

Bills at Browns (-3): These teams are going in opposite directions. Our experts on which will regress.

Cardinals at Buccaneers (-4.5): This is the highest-total game of Week 10. Our staff reveals how they’re betting it.

Lions at Bears (-2.5): Who has the edge in this NFC North matchup? Our experts discuss whether to bet the road dog.

4 ET Games

Dolphins at Colts (-10.5): Indy faces Miami without Jacoby Brissett. Our analysts preview the key matchup in this game.

Panthers at Packers (-4.5): Green Bay is coming off a tough loss. Our experts on whether Aaron Rodgers and Co. can bounce back and cover at home.

Rams (-4) at Steelers: The public likes Los Angeles to cover in Pittsburgh. Our analysts weigh in.

NFL Sharp Report

Pro bettors have keyed in on four Sunday games. Find out how they’re betting Bills-Browns, Lions-Bears, Rams-Steelers and Panthers-Packers.

Pick ‘Em Confidence Ratings

Sean Koerner ranks against-the-spread and straight-up picks for pick ’em pools. Read how he stacks all 32 teams for Week 10.

NFL Prop Bets

Player props offer tremendous value on the board every week. Here are five we’re eyeing for Week 10:

  • Packers RB Jamaal Williams’ Receptions
  • Chiefs RB LeSean McCoy’s Receiving Yards
  • Saints QB Drew Brees’ Passing Touchdowns
  • Packers TE Jimmy Graham’s Receiving Yards
  • Ravens TE Hayden Hurst’s Receiving Yards

See how Mike Randle recommends betting each one.

Survivor Pool Strategy

Nine weeks down, eight to go. We’ve got you covered with the best picks to keep you alive through Week 10.