2021 NFL Odds, Picks, Predictions: Everything You Need To Bet Week 1 This Sunday

2021 NFL Odds, Picks, Predictions: Everything You Need To Bet Week 1 This Sunday article feature image
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Frank Jansky/Icon Sportswire via Getty Images. Pictured: Myles Garrett, Patrick Mahomes

Week 1 NFL Odds

Spread
Kickoff
Preview
49ers -8.5 at Lions
1 p.m. ET
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Chargers at Washington -1.5
1 p.m. ET
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Seahawks -3 at Colts
1 p.m. ET
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Steelers at Bills -6.5
1 p.m. ET
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Jets at Panthers -3.5
1 p.m. ET
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Jaguars -3 at Texans
1 p.m. ET
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Eagles at Falcons -3
1 p.m. ET
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Vikings -3 at Bengals
1 p.m. ET
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Cardinals at Titans -3
1 p.m. ET
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Broncos -3 at Giants
4:25 p.m. ET
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Dolphins at Patriots -3
4:25 p.m. ET
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Browns at Chiefs -5.5
4:25 p.m. ET
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Packers -3.5 at Saints
4:25 p.m. ET
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Compare real-time NFL odds across various sportsbooks here

Week 1 NFL Picks

Our analysts identified the bets they’re most confident in for Sunday:

Click on a pick to read that analysis
Washington -1 vs. Chargers
Chargers-WFT Over 44.5
Eagles +3.5 at Falcons
Seahawks -3 at Colts
Saints +3.5 vs. Packers
Packers-Saints Under 50
Broncos -3 at Giants
Broncos-Giants Under 41.5
Browns +5.5 at Chiefs
Patriots -3 vs. Dolphins

Week 1 NFL Predictions

Action’s Director of Predictive Analytics, Sean Koerner, details the five biggest edges based on his Week 1 NFL Power Ratings. He has a 372-278-4 (57%) all-time record on NFL bets he’s tracked in the Action App, where you can follow all of his picks.

Click on a matchup to read that analysis
Game Koerner’s Pick Kickoff
Chargers at Washington WFT -1 1 p.m. ET
Jets at Panthers Over 44.5 1 p.m. ET
Dolphins at Patriots Dolphins +3.5 4:25 p.m. ET
Broncos at Giants Under 42 4:25 p.m. ET
Packers at Saints Under 50 4:25 p.m. ET

Week 1 NFL Prop Bets

Player props offer some of the best values on the board each week. Sean Koerner highlights his 16 (!) favorite prop bets for Sunday.

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NFL Pick’Em & Survivor Pool Picks

Straight up. Against the spread. Whether you’re playing in your office’s pool or in a higher-stakes contest, Sean Koerner has you covered with his Week 1 Pick ‘Em Confidence Ratings.

What do the numbers suggest is the top survivor pool play for Week 1? Our Data Manager Travis Reed shares his recommendation.


How To Bet On the NFL

You can find reviews of the best online sportsbooks in your states, their latest promos and more in this hub.

Legal online sports betting is currently available in the following states:

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