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Athletics vs Red Sox Prediction, Pick, Odds for Wednesday, September 17

Athletics vs Red Sox Prediction, Pick, Odds for Wednesday, September 17 article feature image
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Photo by Bob DeChiara-Imagn Images. Pictured: Lucas Giolito

The Boston Red Sox host the Athletics on September 17, 2025. First pitch from Fenway Park is scheduled for 6:45 p.m. EDT; the game will be broadcast on NBCS-CA.

Yesterday, the A's won the opener of this three-game series with a 2-1 score.

Find my MLB betting preview and Athletics vs Red Sox prediction below, as well as probable pitchers, betting trends, injury reports and more.

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My Athletics vs Red Sox Prediction

  • Athletics vs Red Sox pick: Under 9 (-115)

My Athletics vs Red Sox best bet is Under 9 total runs in this game. Make sure to find the best odds by checking our live MLB odds page.


Athletics vs Red Sox Odds

Athletics Logo
Wednesday, Sep 17
6:45 p.m. ET
NBCS-CA
Red Sox Logo
Athletics Odds
SpreadTotalMoneyline
+1.5
-130
9
-105o / -115u
+150
Red Sox Odds
SpreadTotalMoneyline
-1.5
+110
9
-105o / -115u
-180
Odds via bet365. Get up-to-the-minute MLB odds here.
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Athletics vs Red Sox Projected Starting Pitchers

RHP Mason Barnett (ATH)StatRHP Lucas Giolito (BOS)
1-1W-L10-4
0.3fWAR (FanGraphs)1.9
8.53 / 3.43ERA / xERA3.31 / 5.00
3.78 / 5.18FIP / xFIP4.17 / 4.44
1.89WHIP1.25
11.1K-BB%11.6
32.6GB%38.1
97Stuff+92
98Location+99

Athletics vs Red Sox Preview

The first game of this series produced a grand total of three runs, and the weather conditions for today are not optimal for hitters, as we'll see in our Bet Labs system.

Last week, these two teams played a series at Sutter Health Park, one of the best in the league for homers and overall run production, and the totals for those games were seven, six, and nine runs.

The A's starter, Mason Barnett, did not do too well against Boston in that series, allowing three runs, but Lucas Giolito is the key piece of this under recommendation for today.

The Red Sox starter holds a 2.67 ERA across his last seven starts and has given up fewer than three earned runs in each of his past four outings.

The "Wind Whisper Unders" system also offers a weather angle for this game.

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Evan Abrams / Bet Labs – Wind Whisper Unders
the over/under % is between 1% and 55%
the average wind speed is between 3 and 15 mph
the closing total is between 7 and 10
the game was played during the 2025 or 2024 or 2023 or 2022 or 2021 or 2020 season
the o/u change from open to close is between -2.5 and 0
the temperature is between 30 and 70 degrees
the wind direction is From Left or In or From Right
betting on the Under
the game is played during the Regular season
$12,744
WON
508-342-46
RECORD
60%
WIN%

The system titled "Wind Whisper Unders" is built for MLB totals where weather and market signals align quietly but consistently toward the under.

It targets regular-season games from 2020 through 2025, where the closing total falls between 7 and 10 runs —a middle range that allows for variance but avoids extremes.

This strategy homes in on games with a specific weather profile: wind blowing from left, in from right, or straight in, with speeds between 3 and 15 miles per hour. Combined with moderate temperatures between 30 and 70, these environmental conditions help suppress deep fly balls without overly skewing the market.

Line movement also plays a role. The total must have dropped by up to 2.5 runs from open to close, signaling steady downward pressure from sharper bettors. Importantly, the public is not fully behind the under; support remains modest, falling between 1 and 55. This indicates market resistance and helps ensure the number isn’t over-adjusted.

By aligning downward line moves, cooling weather patterns, and under-the-radar betting splits, the system consistently identifies games where offense is subtly but significantly less likely to break out.

Pick: Under 9 (-115, bet365)


Athletics vs Red Sox Betting Trends


Athletics vs Red Sox Weather


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