 Ducks | Max Jones | F | Out | Undisclosed | Jones is out with undisclosed | Jan 13 |
 Coyotes | Oliver Ekman-Larsson | D | Out | Head | Oliver Ekman-Larsson (head) will miss at least two games | Jan 17 |
| Coyotes | Ilya Lyubushkin | D | Out | Personal | Lyubushkin is out with personal | Jan 14 |
 Bruins | Brad Marchand | F | Probable | Groin | F Brad Marchand (groin) upgraded to probable Thursday at New Jersey | Jan 14 |
| Bruins | David Pastrnak | F | Out | Hip | Pastrnak is out with hip | Jan 11 |
| Bruins | Karson Kuhlman | F | Probable | COVID Protocols | Kuhlman is probable with covid protocols | Jan 15 |
 Sabres | Zemgus Girgensons | F | Out | Hamstring | Girgensons is out with hamstring | Jan 6 |
| Sabres | Curtis Lazar | F | Probable | Undisclosed | Lazar is probable with undisclosed | Jan 13 |
| Sabres | Kyle Okposo | F | Out | Undisclosed | Okposo is out with undisclosed | Jan 13 |
 Blackhawks | Jonathan Toews | F | Out | Illness | Jonathan Toews (illness) is out indefinitely | Dec 29 |
| Blackhawks | Alexander Nylander | F | Out | Knee | Nylander is out with knee | Dec 23 |
| Blackhawks | Kirby Dach | F | Out | Wrist | Dach is out with wrist | Jan 14 |
 Avalanche | Erik Johnson | D | Out | Undisclosed | Johnson is out with undisclosed | Jan 13 |
 Blue Jackets | Mikko Koivu | F | Out | COVID Protocols | Koivu is out with covid protocols | Jan 13 |
| Blue Jackets | Gustav Nyquist | F | Out | Shoulder | Nyquist is out with shoulder | Jan 11 |
 Stars | Tyler Seguin | F | Out | Hip | Seguin is out with hip | Jan 11 |
| Stars | Ben Bishop | G | Out | Knee | Bishop is out with knee | Jan 11 |
| Stars | Esa Lindell | D | Out | COVID Protocols | Lindell is out with covid protocols | Jan 14 |
 Red Wings | Bobby Ryan | F | Probable | Undisclosed | Ryan is probable with undisclosed | Jan 15 |
| Red Wings | Darren Helm | F | Out | COVID Protocols | Helm is out with covid protocols | Jan 13 |
 Oilers | Mike Smith | G | Out | Undisclosed | Smith is out with undisclosed | Jan 15 |
| Oilers | James Neal | F | Out | COVID Protocols | Neal is out with covid protocols | Jan 13 |
| Oilers | Gaetan Haas | F | Probable | Illness | Haas is probable with illness | Jan 16 |
 Panthers | Sergei Bobrovsky | G | Out | Undisclosed | Sergei Bobrovsky (undisclosed) is out indefinitely | Jan 12 |
| Panthers | Markus Nutivaara | D | Out | Undisclosed | Nutivaara is out with undisclosed | Jan 15 |
 Wild | Mats Zuccarello | F | Out | Arm | Zuccarello is out with arm | Jan 11 |
| Wild | Alex Stalock | G | Out | COVID Protocols | Stalock is out with covid protocols | Jan 14 |
| Wild | Marco Rossi | F | Out | Upper Body | Rossi is out with upper body | Jan 11 |
 Predators | Mikael Granlund | F | Out | COVID Protocols | Granlund is out with covid protocols | Jan 12 |
| Predators | Viktor Arvidsson | F | Probable | Undisclosed | Arvidsson is probable with undisclosed | Jan 14 |
 Devils | Miles Wood | F | Probable | Illness | Wood is probable with illness | Feb 25 |
| Devils | Jesper Bratt | F | Out | Undisclosed | Bratt is out with undisclosed | Jan 15 |
| Devils | Nico Hischier | F | Out | Leg | Hischier is out with leg | Jan 12 |
 Islanders | Ryan Pulock | D | Probable | Head | Pulock is probable with head | Feb 10 |
| Islanders | Michael Dal Colle | F | Out | Undisclosed | Dal Colle is out with undisclosed | Jan 13 |
| Islanders | Sebastian Aho | D | Out | Undisclosed | Aho is out with undisclosed | Jan 15 |
 Rangers | Kevin Rooney | F | Out | Undisclosed | Rooney is out with undisclosed | Jan 16 |
 Flyers | Sean Couturier | F | Out | Shoulder | Sean Couturier (shoulder) out a minimum of two weeks. | Jan 16 |
| Flyers | Shayne Gostisbehere | D | Out | COVID Protocols | Gostisbehere is out with covid protocols | Jan 13 |
 Penguins | Kasperi Kapanen | F | Out | COVID Protocols | Kapanen is out with covid protocols | Jan 12 |
| Penguins | Michael Matheson | D | Out | Upper Body | Matheson is out with upper body | Jan 17 |
| Penguins | Zachary Aston-Reese | F | Out | Shoulder | Aston-Reese is out with shoulder | Jan 4 |
 Sharks | Radim Simek | D | Questionable | Knee | Simek is questionable with knee | Jan 11 |
| Sharks | Maxim Letunov | F | Out | COVID Protocols | Letunov is out with covid protocols | Jan 14 |
 Blues | Mike Hoffman | F | Questionable | Personal | Hoffman is questionable with personal | Jan 14 |
| Blues | Vladimir Tarasenko | F | Out | Shoulder | Tarasenko is out with shoulder | Jan 11 |
| Blues | Sammy Blais | F | Questionable | Disciplinary | Blais is questionable with disciplinary | Jan 14 |
 Canucks | Micheal Ferland | F | Out | Head | Ferland is out with head | Jan 13 |
| Canucks | J.T. Miller | F | Probable | COVID Protocols | J.T. Miller (COVID protocols) upgraded to probable Monday at Calgary | Jan 17 |
 Capitals | Michal Kempny | D | Out | Achilles | Kempny is out with achilles | Jan 11 |
 Jets | Jansen Harkins | F | Out | Undisclosed | Harkins is out with undisclosed | Jan 14 |
| Jets | Dominic Toninato | F | Out | Undisclosed | Toninato is out with undisclosed | Jan 13 |