 Ducks | Jakob Silfverberg | F | Out for season | Hip | Silfverberg is out for season with hip | Apr 23 |
| Ducks | Hampus Lindholm | D | Out | Wrist | Lindholm is out with wrist | Mar 5 |
| Ducks | Andy Welinski | D | Out | Lower Body | Welinski is out with lower body | Apr 29 |
| Ducks | Sonny Milano | F | Out | Undisclosed | Milano is out with undisclosed | Mar 5 |
| Ducks | Carter Rowney | F | Out | Knee | Rowney is out with knee | Mar 19 |
 Coyotes | Antoine Roussel | F | Out | Lower Body | Roussel is out with lower body | Apr 22 |
| Coyotes | Carter Hutton | G | Out for season | Lower Body | Hutton is out for season with lower body | May 4 |
| Coyotes | Nick Schmaltz | F | Questionable | Head | Schmaltz is questionable with head | May 4 |
| Coyotes | Jordan Gross | D | Out | Lower Body | Gross is out with lower body | Apr 13 |
 Bruins | Mike Reilly | D | Out | Undisclosed | Reilly is out with undisclosed | May 3 |
| Bruins | Charlie Coyle | F | Probable | Upper Body | Coyle is probable with upper body | May 12 |
| Bruins | Curtis Lazar | F | Out | Lower Body | Lazar is out with lower body | Jun 8 |
| Bruins | John Moore | D | Out for season | Lower Body | Moore is out for season with lower body | Mar 27 |
| Bruins | Ondrej Kase | F | Out | Upper Body | Kase is out with upper body | May 14 |
| Bruins | Linus Ullmark | G | Out for season | Lower Body | Ullmark is out for season with lower body | May 7 |
| Bruins | Tomas Nosek | F | Questionable | Undisclosed | Nosek is questionable with undisclosed | Jun 18 |
 Sabres | Aaron Dell | G | Out | COVID Protocols | Dell is out with covid protocols | Jan 28 |
| Sabres | Jack Eichel | F | Out for season | Neck | Jack Eichel (neck) will miss remainder of the season | Apr 14 |
| Sabres | Zemgus Girgensons | F | Out for season | Hamstring | Girgensons is out for season with hamstring | Apr 20 |
| Sabres | Riley Sheahan | F | Out | Upper Body | Sheahan is out with upper body | Apr 17 |
| Sabres | Kyle Okposo | F | Out for season | Face | Okposo is out for season with face | Apr 17 |
| Sabres | Dustin Tokarski | G | Out for season | Personal | Tokarski is out for season with personal | May 4 |
| Sabres | Ukko-Pekka Luukkonen | G | Out for season | Lower Body | Luukkonen is out for season with lower body | May 4 |
 Flames | Sean Monahan | F | Out for season | Hip | Sean Monahan (hip) will miss the remainder of the season | May 12 |
| Flames | Noah Hanifin | D | Out for season | Shoulder | Hanifin is out for season with shoulder | Apr 27 |
| Flames | Joakim Nordstrom | F | Probable | Lower Body | Nordstrom is probable with lower body | Mar 26 |
| Flames | Tyler Pitlick | F | Out for season | Lower Body | Pitlick is out for season with lower body | May 5 |
 Hurricanes | Antti Raanta | G | Out | Upper Body | Raanta is out with upper body | Apr 26 |
| Hurricanes | Jake Gardiner | D | Questionable | Upper Body | Gardiner is questionable with upper body | Mar 8 |
| Hurricanes | Martin Necas | F | Probable | Undisclosed | Necas is probable with undisclosed | Feb 14 |
 Blackhawks | Jake McCabe | D | Out for season | Knee | McCabe is out for season with knee | Feb 23 |
| Blackhawks | Jonathan Toews | F | Out for season | Undisclosed | Toews is out for season with undisclosed | Apr 22 |
| Blackhawks | Calvin de Haan | D | Out | Hip | de Haan is out with hip | Apr 23 |
| Blackhawks | Ryan Carpenter | F | Out | Concussion | Carpenter is out with concussion | Apr 26 |
| Blackhawks | Alexander Nylander | F | Out | Knee | Nylander is out with knee | Dec 23 |
| Blackhawks | Wyatt Kalynuk | D | Questionable | Hip | Kalynuk is questionable with hip | Apr 21 |
| Blackhawks | Kirby Dach | F | Out for season | Wrist | Dach is out for season with wrist | May 6 |
 Avalanche | J.T. Compher | F | Probable | Upper Body | Compher is probable with upper body | Mar 17 |
 Blue Jackets | Gustav Nyquist | F | Out for season | Shoulder | Nyquist is out for season with shoulder | Apr 17 |
| Blue Jackets | Joonas Korpisalo | G | Out | Lower Body | Korpisalo is out with lower body | Apr 27 |
| Blue Jackets | Zac Dalpe | F | Out for season | Lower Body | Dalpe is out for season with lower body | May 6 |
| Blue Jackets | Zach Werenski | D | Out for season | Abdominal | Zach Werenski (abdominal) will miss remainder of the season | Apr 9 |
| Blue Jackets | Alexandre Texier | F | Out | Lower Body | Texier is out with lower body | May 5 |
| Blue Jackets | Adam Boqvist | D | Out for season | Wrist | Boqvist is out for season with wrist | Apr 28 |
 Stars | Tyler Seguin | F | Out for season | Undisclosed | Seguin is out for season with undisclosed | May 9 |
| Stars | Luke Glendening | F | Probable | Upper Body | Glendening is probable with upper body | Feb 13 |
| Stars | Ben Bishop | G | Out for season | Knee | Ben Bishop (knee) will miss remainder of the season | Apr 14 |
| Stars | Alexander Radulov | F | Out for season | Lower Body | Alexander Radulov (lower body) will miss remainder of the season | Apr 14 |
| Stars | Roope Hintz | F | Out for season | Groin | Hintz is out for season with groin | May 11 |
 Red Wings | Bobby Ryan | F | Out for season | Upper Body | Ryan is out for season with upper body | Apr 9 |
| Red Wings | Robby Fabbri | F | Out for season | Upper Body | Fabbri is out for season with upper body | May 5 |
| Red Wings | Dylan Larkin | F | Out for season | Upper Body | Dylan Larkin (upper body) will miss remainder of the season | Apr 23 |
| Red Wings | Frans Nielsen | F | Questionable | Undisclosed | Nielsen is questionable with undisclosed | Apr 18 |
| Red Wings | Tyler Bertuzzi | F | Out for season | Upper Body | Bertuzzi is out for season with upper body | Apr 22 |
| Red Wings | Adam Erne | F | Out | Undisclosed | Erne is out with undisclosed | May 8 |
 Oilers | Duncan Keith | D | Out | Concussion | Keith is out with concussion | May 7 |
| Oilers | Warren Foegele | F | Out | Upper Body | Foegele is out with upper body | Jun 8 |
| Oilers | Evan Bouchard | D | Probable | Back | Bouchard is probable with back | Feb 2 |
| Oilers | Dominik Kahun | F | Out | Undisclosed | Kahun is out with undisclosed | Mar 4 |
| Oilers | Joakim Nygard | F | Out | Hand | Nygard is out with hand | Apr 23 |
 Panthers | Sam Reinhart | F | Questionable | Undisclosed | Reinhart is questionable with undisclosed | Feb 15 |
| Panthers | Aaron Ekblad | D | Out for season | Leg | Ekblad is out for season with leg | Mar 30 |
| Panthers | Lucas Wallmark | F | Out | COVID Protocols | Wallmark is out with covid protocols | Jan 27 |
| Panthers | Markus Nutivaara | D | Out | Upper Body | Nutivaara is out with upper body | Mar 5 |
 Kings | Jonathan Quick | G | Out | Upper Body | Quick is out with upper body | May 5 |
| Kings | Alexander Edler | D | Out | Undisclosed | Edler is out with undisclosed | May 19 |
| Kings | Viktor Arvidsson | F | Out | Upper Body | Arvidsson is out with upper body | May 23 |
| Kings | Olli Maatta | D | Out | Upper Body | Maatta is out with upper body | Mar 22 |
| Kings | Blake Lizotte | F | Out | Upper Body | Lizotte is out with upper body | May 1 |
 Wild | Marcus Johansson | F | Out | Arm | Johansson is out with arm | May 21 |
| Wild | Marco Rossi | F | Out for season | Illness | Rossi is out for season with illness | Mar 6 |
 Canadiens | Jonathan Drouin | F | Questionable | Illness | Drouin is questionable with illness | Apr 26 |
| Canadiens | Jake Evans | F | Probable | Concussion | Evans is probable with concussion | Jun 28 |
 Predators | Luca Sbisa | D | Out | Upper Body | Sbisa is out with upper body | Jan 25 |
| Predators | Mattias Ekholm | D | Probable | Undisclosed | Ekholm is probable with undisclosed | Feb 27 |
| Predators | Mark Borowiecki | D | Probable | Upper Body | Borowiecki is probable with upper body | Mar 28 |
 Islanders | Jean-Gabriel Pageau | F | Probable | Undisclosed | Pageau is probable with undisclosed | Jun 17 |
| Islanders | Anders Lee | F | Out for season | Lower Body | Lee is out for season with lower body | Mar 17 |
| Islanders | Michael Dal Colle | F | Out | Undisclosed | Dal Colle is out with undisclosed | May 27 |
 Rangers | Artemi Panarin | F | Doubtful | Lower Body | Panarin is doubtful with lower body | May 4 |
| Rangers | Chris Kreider | F | Out | Lower Body | Kreider is out with lower body | May 3 |
| Rangers | Jacob Trouba | D | Out for season | Upper Body | Trouba is out for season with upper body | May 4 |
| Rangers | Jack Johnson | D | Out | Hernia | Johnson is out with hernia | Mar 20 |
| Rangers | Julien Gauthier | F | Questionable | Lower Body | Gauthier is questionable with lower body | May 6 |
| Rangers | Ryan Lindgren | D | Out for season | Upper Body | Lindgren is out for season with upper body | May 4 |
 Senators | Austin Watson | F | Out for season | Hand | Watson is out for season with hand | Apr 27 |
| Senators | Derek Stepan | F | Out for season | Upper Body | Stepan is out for season with upper body | Mar 2 |
| Senators | Matt Murray | G | Out | Lower Body | Murray is out with lower body | Apr 26 |
| Senators | Micheal Haley | F | Out for season | Groin | Haley is out for season with groin | Apr 2 |
| Senators | Thomas Chabot | D | Out for season | Upper Body | Thomas Chabot (upper body) will likely miss remainder of the season | May 4 |
| Senators | Josh Brown | D | Out for season | Undisclosed | Brown is out for season with undisclosed | May 4 |
 Flyers | Justin Braun | D | Out | Foot | Braun is out with foot | May 11 |
| Flyers | Sean Couturier | F | Probable | Hip | Sean Couturier (hip) upgraded to Probable Monday vs. NY Islanders | Mar 22 |
| Flyers | Carter Hart | G | Out | Knee | Hart is out with knee | Apr 22 |
| Flyers | Tanner Laczynski | F | Out for season | Hip | Laczynski is out for season with hip | Apr 27 |
| Flyers | Morgan Frost | F | Out for season | Shoulder | Frost is out for season with shoulder | Feb 19 |
 Penguins | Kasperi Kapanen | F | Probable | Lower Body | Kapanen is probable with lower body | Apr 22 |
| Penguins | Casey DeSmith | G | Out | Lower Body | DeSmith is out with lower body | May 16 |
| Penguins | Zachary Aston-Reese | F | Probable | Shoulder | Aston-Reese is probable with shoulder | Feb 11 |
 Sharks | Matt Nieto | F | Out | Lower Body | Nieto is out with lower body | Mar 28 |
| Sharks | Andrew Cogliano | F | Questionable | Illness | Cogliano is questionable with illness | Mar 21 |
| Sharks | Joachim Blichfeld | F | Out | Concussion | Blichfeld is out with concussion | May 4 |
| Sharks | Timo Meier | F | Probable | Lower Body | Meier is probable with lower body | Mar 11 |
| Sharks | Jeffrey Viel | F | Out | Eye | Viel is out with eye | May 11 |
| Sharks | John Leonard | F | Out | Concussion | Leonard is out with concussion | May 11 |
 Blues | Tyler Bozak | F | Out | Rest | Bozak is out with rest | May 12 |
| Blues | Jordan Kyrou | F | Out | Illness | Kyrou is out with illness | Apr 17 |
 Lightning | Alex Killorn | F | Out | Leg | Killorn is out with leg | Jul 7 |
 Maple Leafs | Jake Muzzin | D | Out | Lower Body | Muzzin is out with lower body | May 31 |
| Maple Leafs | Ben Hutton | D | Out | Undisclosed | Hutton is out with undisclosed | May 20 |
| Maple Leafs | Jason Spezza | F | Out | Coach's decision | Spezza is out with coach's decision | Jan 25 |
| Maple Leafs | John Tavares | F | Out | Concussion | Tavares is out with concussion | May 25 |
 Canucks | Tanner Pearson | F | Out | Personal | Pearson is out with personal | May 19 |
| Canucks | Micheal Ferland | F | Out | Head | Ferland is out with head | Jan 13 |
| Canucks | Justin Bailey | F | Questionable | Upper Body | Bailey is questionable with upper body | Feb 12 |
| Canucks | Tyler Motte | F | Out | Undisclosed | Motte is out with undisclosed | May 4 |
| Canucks | Nic Petan | F | Out | Undisclosed | Petan is out with undisclosed | Mar 6 |
| Canucks | Elias Pettersson | F | Out for season | Upper Body | Pettersson is out for season with upper body | May 13 |
 Golden Knights | Alex Pietrangelo | D | Probable | Undisclosed | Pietrangelo is probable with undisclosed | Mar 31 |
| Golden Knights | Chandler Stephenson | F | Questionable | Upper Body | Stephenson is questionable with upper body | Jun 22 |
| Golden Knights | Peyton Krebs | F | Out | Jaw | Krebs is out with jaw | May 28 |
 Capitals | Brian Pinho | F | Out | Undisclosed | Pinho is out with undisclosed | Feb 19 |
 Jets | Jordie Benn | D | Probable | Undisclosed | Benn is probable with undisclosed | Mar 10 |
| Jets | Mark Scheifele | F | Out | Suspension | Scheifele is out with suspension | Jun 4 |
| Jets | Nathan Beaulieu | D | Out for season | Upper Body | Beaulieu is out for season with upper body | Apr 2 |
| Jets | Dylan DeMelo | D | Out | Lower Body | DeMelo is out with lower body | Jun 4 |
| Jets | Dominic Toninato | F | Out | Undisclosed | Toninato is out with undisclosed | Jun 4 |