The panel just made its College GameDay picks, so use the bet365 bonus code to get the $200 Bet-and-Get promo for the Ohio State vs. Iowa game at 3:30 p.m. ET on CBS.
It's going to be a crazy day in Iowa City, and the arrival of guest picker Caitlin Clark sent this rawkus crowd over the top. While the atmosphere will be top-notch, it will be a tough matchup for the Hawkeyes against the class of the Big Ten. Iowa comes in with a perfect 4-0 record, but two of those wins against quality opponents came by a combined four points. Meanwhile, Ohio State's 3-1 mark has the lone blemish from the No. 1 team in the nation, and oddsmakers see what a machine the Buckeyes are, labeling them 14.5-point favorites on the road. If you think the Hawkeyes can pull off the upset, follow along with Clark's pick using the bonus bets you score from the $200 Bet-and-Get promos.
A huge day of college football is ahead, and you can still catch live numbers on Alabama vs. Mississippi State (12 p.m. ET, ABC) and Notre Dame vs. UNC (12 p.m. ET, ESPN) in the early window. Alongside the Ohio State-Iowa Big Ten showdown, Florida vs. Missouri (3:30 p.m. ET, ABC) kicks off a huge SEC matchup. In primetime, Miami (FL) vs. Clemson (7:30 p.m. ET, ABC) winds down a long Saturday of action on the collegiate gridiron.
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- Fire off a $10 bet on Ohio State-Iowa or any other Week 5 matchup.
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bet365 CFB Odds: Ohio State vs. Iowa Preview
Let's take a look at the odds bet365 is offering for the big game between Texas and Tennessee:
| Team | Spread | Moneyline | Total Points |
|---|---|---|---|
| Ohio State Buckeyes | -14.5 (-105) | -650 | Over 45.5 (-110) |
| Iowa Hawkeyes | +14.5 (-115) | +475 | Under 45.5 (-110) |
Kickoff for Ohio State vs. Iowa is at 3:30 p.m. ET on Saturday, October 3, 2026. Always check bet365 for the most up-to-date odds before the game begins.
Ohio State (3-1, 1-0 Big Ten) heads to Kinnick Stadium to face an undefeated Iowa squad (4-0, 1-0 Big Ten) in a Week 5 matchup that's shaping up as a classic clash of styles. The Buckeyes' explosive, pass-heavy attack behind QB Julian Sayin and the record-setting WR Jeremiah Smith will face Iowa's grind-it-out, defense-and-field-position identity under Kirk Ferentz. Ohio State is coming off a 42-19 statement win over Illinois while Iowa just survived a last-second 20-19 escape at Michigan.
The number here is worth watching closely. Ohio State opened at -14 and has since moved up to -14.5 at several books; a half-point bump that looks small but sits right in a sensitive area of the market. Moves off 14 matter because two scores (14 points) is one of the most common final margins in football, so shifting the line even a half-point past it can meaningfully change the outcome. That kind of movement usually signals sharp money leaning Buckeyes, or books adjusting after early public action came in heavy on Ohio State.
Given that, there's a real case for buying back some points rather than taking the inflated number. Grabbing Ohio State at -12.5 (-142) or -13.5 (-130) costs more in juice, but it moves you off that two-score threshold and gives you real insurance if Iowa controls the clock and its defense keeps it close late. The buy is more expensive straight-up, which is why it tends to make more sense as part of a parlay, where the reduced-juice version of the spread combines with other legs instead of eating into a single-game bet's value on its own.
College GameDay Predictions from the Panel
- Desmond Howard: Iowa
- Nick Saban: Ohio State
- Kirk Herbstreit: Ohio State
- Pat McAfee: Ohio State
- Caitlin Clark: Iowa
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