San Francisco 49ers Odds3rd in NFC West
- ATS Record
- 29th Overall
- Rushing Yards
- 610 RYPG
- Passing Yards
- 1231 PYPG
- Total Yards
- 1841 YPG
49ers vs Colts OddsMore Odds
Best 49ers Betting Sites
49ers InjuriesAll NFL Injuries
Jimmy Garoppolo (Undisclosed) is out this week.
K'Waun Williams (calf) is out this week.
Raheem Mostert (Knee) is out for the season.
Out for Season
Jason Verrett (Knee) is out for the season.
Out for Season
George Kittle (Undisclosed) is doubtful this week.
Samson Ebukam (hamstring) is questionable this week.
Jeff Wilson Jr.RB
Jeff Wilson (Undisclosed) is out this week.
Jalen Hurd (Knee) is out this week.
Javon Kinlaw (knee) is questionable this week.
JaMycal Hasty (Ankle) is out this week.
Trey Lance (Undisclosed) is questionable this week.
49ers 2021 Schedule
|Oct 10th||@ARI||L 10-17||+5.5 L||U 48.5||ARI +194|
|Oct 3rd||SEA||L 21-28||-2.5 L||U 52||SEA -135|
|Sep 27th||GB||L 28-30||-3.5 L||O 50.5||GB -172|
|Sep 19th||@PHI||W 17-11||-3 W||U 49||SF -148|
|Sep 12th||@DET||W 41-33||-9.5 W||O 46.5||SF -425|
|Aug 29th||LV||W 34-10||-5.5 W||O 36||SF -235|
|Aug 22nd||@LAC||W 15-10||-6.5 W||U 35||SF -290|
|QB||Jimmy Garoppolo||Trey Lance|
|RB||Raheem Mostert||Trey Sermon||JaMycal Hasty|
|WR||Trent Sherfield||Deebo Samuel||Mohamed Sanu||Jauan Jennings||Brandon Aiyuk|
|TE||George Kittle||Charlie Woerner||Ross Dwelley|
|LT||Trent Williams||Jaylon Moore|
|LG||Laken Tomlinson||Tom Compton||Aaron Banks|
|LDE||Arik Armstead||Dee Ford|
|LDT||Zach Kerr||Maurice Hurst||Kevin Givens|
|RDT||Javon Kinlaw||David Jones|
|RDE||Nick Bosa||Kentavius Street||Arden Key|
|LCB||Jason Verrett||Deommodore Lenoir||Dontae Johnson|
|SS||Jaquiski Tartt||Marcell Harris||Tavon Wilson||Talanoa Hufanga|
|RCB||Ambry Thomas||Davontae Harris||Josh Norman|
|PR||Brandon Aiyuk||Mohamed Sanu|
|KR||JaMycal Hasty||Ambry Thomas||Elijah Mitchell|
|MIKE||Fred Warner||Azeez Al-Shaair|
|WILL||Demetrius Flannigan-Fowles||Samson Ebukam|
San Francisco 49ers Player Stats
passing yardsJimmy Garoppolo925pyds
passing touchdownsJimmy Garoppolo5ptd
rushing yardsElijah Mitchell189ryds
rushing touchdownsJaMycal Hasty1rtd
San Francisco 49ers Odds, Bet Types, and Team History
The San Francisco 49ers’ NFC title defense couldn’t have gone much worse. A year after winning 13 games and holding a lead in the Super Bowl through three quarters, San Francisco was riddled with injuries and couldn’t get its core players on the field together. The 49ers started 4-3 in spite of those injury woes before losing seven of nine games and finishing fourth in the NFC West at 6-10. While this might feel like a major step back in the Bay, a healthy Niners roster is a much different team, one that you’ll want to keep an eye on in 2021.
There’s still some uncertainty about who San Francisco will roll out under center in Week 1. Jimmy Garoppolo is the most seasoned QB on the roster and likely to get the first crack at the starting job, The eighth-year pro wasn’t great last season, throwing for 1,096 yards, seven touchdowns and five interceptions in six games. It’s also possible that rookie QB Trey Lance wins the job, though it’s more probable that he needs some time to develop. San Francisco traded three first-round picks to move up and select Lance third overall in the 2021 NFL draft. The North Dakota State product is a dual-threat QB who racked up 3,886 scrimmage yards, 42 touchdowns and zero interceptions in his lone full season at NDSU, leading the Bison to an FCS championship in 2019.
San Francisco’s ground game could also look different this season. The Niners had the NFL’s No. 2 rushing offense in 2019, averaging 144.1 yards per game. They finished 15th in 2020 with 118.1 yards per game. Injuries forced head coach Kyle Shanahan to start four different running backs last year without the committee approach used to reach the Super Bowl. Jeff Wilson played in 12 games and led the team in rushing with 600 yards — he had 183 of that in one game — while Raheem Mostert rushed for 521 yards in eight games. Having the capability to use those two in tandem should allow for some more creativity in Shanahan’s offense.
Whether it’s Garoppolo or Lance throwing the ball, the Niners operate with one of the league’s more unique receiver groupings and will need them all healthy for the offense to have a chance at reaching its full potential. Deebo Samuel played in seven games while tight end George Kittle appeared in eight contests, leaving San Francisco without its top two receivers for much of the season. However, the injuries did allow some younger players to develop faster with additional snaps. Kendrick Bourne had a career-best 49 catches for 667 yards in his fourth season while 2020 first-round pick Brandon Aiyuk led the team with 60 receptions, 748 yards and five scores in addition to a pair of rushing touchdowns. If all four players can stay on the field, either QB will have some versatile options to work with.
San Francisco defensive coordinator Robert Saleh is gone, now head coach of the New York Jets . DeMeco Ryans is now running the defense and should get one of his top players back in 2021. The 49ers defense was arguably hit even harder by the injury bug last year and many of those players have since departed in free agency. Nick Bosa returns after only playing in two games due to a torn ACL. The 2019 AP Defensive Rookie of the Year will look to bounce back and build off a nine-sack season from his first year. Dee Ford is also back after playing in one game. The heartbeat of this defense will likely be the linebackers. Dre Greenlaw has 178 tackles through his first two years and has become a strong complement to All-Pro linebacker Fred Warner . Warner racked up 125 total tackles, six pass breakups, two interceptions, one sack and a forced fumble in 2020.
San Francisco opens the 2021 NFL season on the road at the Detroit Lions. You can view the Action Network’s top odds for the game below in addition to an odds comparison for every Week 1 game right here.
Week 7 Odds: San Francisco 49ers vs. Indianapolis Colts (via BetMGM)
|San Francisco 49ers||(-4)-115||-200||Over 44(-110)|
|Indianapolis Colts||(+4)-105||+165||Under 44(-110)|
More: Matchup Page
49ers Offseason Movement 2021
Re-signings: Fred Warner (LB, five years), Jason Verrett (CB, one-year), Kyle Juszczyk (FB, five years), Dee Ford (DE, two years), Trent Williams (T, six years), Emmanuel Moseley (CB, two years)
Free-agent signings: Alex Mack (C, one year)
49ers Team Rivals
San Francisco has won the NFC West three times in the past 10 seasons, most recently in 2019. Injuries tested the 49ers on both sides of the ball last year as they went from first to fourth in the division with a 6-10 season. But remember, these same Niners are just two years removed from a Super Bowl appearance. The Seattle Seahawks won the division in 2020, their fifth division crown in 11 seasons after going 12-4. The Los Angeles Rams went 10-6 to earn a wild card berth and eliminated Seattle in the Wild Card round. The Arizona Cardinals went 8-8 in 2020 and probably would’ve made the playoffs if not for a 2-5 finish to the season. The point here is all four teams in the NFC West are more than capable of competing and you’re not going to want to miss much of the action this season.
Find weekly San Francisco 49ers odds above. Below you’ll find how to bet on the 49ers as well as their complete 2021 schedule, betting trends, performance against-the-spread (ATS), injury history, a full depth chart and more.
Betting on the San Francisco 49ers
San Francisco 49ers Point Spreads
Betting point spreads are wagers based on the expectation that a team will win or lose by a certain number of points. The 49ers went 6-10 overall but were actually one game better when it came to covering in 2020, going 7-9 against the spread. San Francisco’s six wins were by an average margin of 15.2 points while its four losses came by an average of 10.5 points.
Here’s an example:
- 49ers +3.5 (+110)
- Cardinals -3.5 (-110)
In this situation, the 49ers are 3.5 point underdogs against the Cardinals. If Arizona wins the game by four or more points, a $100 wager on the Cardinals would come with a payout of $90.91. If San Francisco won the game outright or lost by three points or less, the same $100 wager would net $110 plus the original $100 for a total of $210.
San Francisco 49ers Over/Unders
Over/under, also called point total, is a wager placed on the combined scoring of a single game. Bookmakers come up with a number and you can either bet the over or — you guessed it — the under. Here’s how it works:
Let's say the 49ers play the Rams and the over/under is set at 52 points. A wager on the over would require San Francisco and Los Angeles to score 53 total points or more to win. Betting the under is an expectation that the two teams would score 51 or fewer points. It's also possible for the bet to push, which would happen if the game finished with exactly 52 points scored.
In 2020, San Francisco averaged 23.5 points per game and allowed 24.4 points per game. The under hit in 50% of their games last season.
The moneyline is as straightforward as it gets when it comes to betting. The only thing to do here is pick the winner. Check out this example:
- 49ers -160
- Seahawks +250
The minus (-) and plus (+) signs distinguish the favorite from the underdog, making San Francisco the favorite in this scenario. Odds can be understood more clearly if you think in terms of $10 or $100 increments. A wager on the 49ers odds would mean every $16 bet nets $10. And it's the opposite for underdogs: Here the Seahawks moneyline was set at +250, meaning a $10 wager would profit $25.
Moneylines are also commonly used when making parlays, which are multiple bets tied into one. Let’s say you bet the 49ers moneyline and a -4.5 point spread, San Francisco would need to win by five points or more for that bet to be successful. The risk is greater, but so is the reward with increased odds. Use our Odds Calculator to calculate any bet amount or conversion.
San Francisco 49ers Props
Player props are wagers on a single player, and they're tied to a single stat found in the box score for a game or even the whole season. These are among the most fun to bet on, especially if you're already playing fantasy football and like the player-specific focus it offers. Check out a hypothetical example below:
- Fred Warner: Over 135 total tackles
Let’s break it down. Warner averaged 7.8 tackles per game in 2020, the highest average of his first three years in the NFL. Assume he takes another step forward in his fourth year and gets up to 8.5 tackles per game in 2021. Warner maintaining that average over a 16-game season means he’d finish with 136 tackles, already hitting the over. Remember the NFL added an additional regular season game. Warner has also never missed a game, which would bring him to 144.5 tackles.
Futures are somewhat similar to prop bets in the way that both are monitored over the course of a season. Except most future bets are focused on end of season success. Examples of futures are:
- San Francisco 49ers odds to win the NFC West
- San Francisco 49ers odds to win the NFC
- San Francisco 49ers odds to win the Super Bowl
- Nick Bosa’s odds to win Defensive Player of the Year
- Trey Lance’s odds to win Rookie of the Year
If you’re confident that Nick Bosa is ready to bounce back from injury in a big way or that a healthy Niners team can return to the Super Bowl, this is the place to be. For a full list of NFL futures, click or tap here.
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