49ers vs. Chargers Odds & Betting Predictions - August 21, 2026
49ers at Chargers
2:00 am • NFL Network49ers at Chargers Odds
Spread, Total, Moneyline
MatchupOpenSpreadTotalMoneyline | ||||
|---|---|---|---|---|
 49ers 3-0 | +1.5 | +2.5-111 | o44.5-110 | +132 |
 Chargers 0-3 | u39.5 | -2.5-109 | u44.5-110 | -157 |
SoFi StadiumInglewood
49ers vs. Chargers Expert Picks
Sir Lockselot
Last 30d: 7-34-0 (-15.6u)
SF +105
$136.50
📚Onyx
OldSchool0909
Last 30d: 93-133-2 (-41.4u)
LAC +1.5-118
1u
Bet Labs
Last 30d: 9-10-1 (-2.3u)
LAC +1.5-110
1.1u
Gilles Gallant
Last 30d: 20-36-0 (+8.5u)
SF +100 (1H)
0.5u
#Tailing @The_Oddsmaker
Collin Whitchurch
Last 30d: 74-82-0 (+6.4u)
SF -115 (1H)
0.5u
Sean Koerner🔮
Last 30d: 31-40-0 (-2.8u)
SF -120 (1H)
0.5u
It’s preseason, which is a total shit show where anything can change at any time, but it does sound like Purdy will play (some) tonight which should help offset Herbert/starters getting 1-2 series to start the game. More importantly, it means we should see Mac Jones make his preseason debut as well which would make it Jones vs. Lance for 1-1.5 quarters which gives SF a big enough edge to take 1H here. That edge could flip 2H with Rourke likely out.
Full betting preview here 👇
https://www.actionnetwork.com/article/p/604417106
Lock & Cash
Last 30d: 12-8-1 (+4.2u)
LAC +1.5-110
1u
Babs .
Last 30d: 59-49-1 (+6.3u)
LAC -110
2u
49ers vs. Chargers Previews & Analysis
49ers vs. Chargers Props
Prop Projections
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Prop Odds Comparison
Line Movement Tracker
49ers vs. Chargers Public Betting Percentages
Betting Trends
- Chargers are 0-3 in their last 5 games.
- Chargers are 0-3 in their last 5 games against the spread
- Chargers are 0-1 in their road games against the spread
- The totals have gone OVER in 0 of Chargers' last 3 games
- The totals have gone OVER in 0 of Chargers' 2 last games at home
Matchup History
Against the Spread (ATS) History
Over/Under History
Last 5 Matchups
49ers vs. Chargers Injury Updates
49ers Injuries
- Mike EvansWR
Evans is questionable with ribs
Questionable
- Demarcus RobinsonWR
Robinson is out with ankle
Out
- Christian KirkWR
Kirk is out with calf
Out
- Jake TongesTE
Tonges is out with knee
Out
- De'Zhaun StriblingWR
Stribling is out with ankle
Out
Chargers Injuries
- David NjokuTE
Njoku is out with leg
Out
- Gary JenningsWR
Gary Jennings (Concussion) is out this week.
Out
- Charlie KolarTE
Kolar is doubtful with arm
Doubtful
- KeAndre Lambert-SmithWR
Lambert-Smith is out with hamstring
Out
- Brenen ThompsonWR
Thompson is questionable with quad
Questionable
Team Stats
49ers vs. Chargers Odds Comparison
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49ers at Chargers Team Totals
MatchupOverUnder | ||
|---|---|---|
49ers 3-0 | N/A | N/A |
Chargers 0-3 | N/A | N/A |