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49ers vs. Chargers Odds & Betting Predictions - August 21, 2026

49ers at Chargers

2:00 am

San Francisco 49ers

0-0
@

Los Angeles Chargers

0-0

49ers at Chargers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
0-0
N/A
N/A
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Chargers
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location pinFriday 2:00 a.m.
August 21, 2026
SoFi StadiumInglewood

49ers vs. Chargers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Chargers Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Chargers

50%

Bets%

50%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Chargers		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Chargers		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Chargers		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Jan 12th@NEL 3-16+3.5 LU 45.5NE +159
Jan 4th@DENL 3-19+15.5 LU 37.5DEN +908
Dec 27thHOUL 16-20-1.5 LU 41HOU -119
Dec 21st@DALW 34-17+1.5 WO 50.5LAC -102
Dec 14th@KCW 16-13+5.5 WU 41.5LAC +222

49ers vs. Chargers Injury Updates

49ers Injuries

  • George Kittle
    TE

    Kittle is out with achilles

    Out

  • Brandon Aiyuk
    WR

    Aiyuk is out with knee

    Out

  • Colton Dowell
    WR

    Dowell is out with knee

    Out

  • Jacob Cowing
    WR

    Cowing is out with hamstring

    Out

Chargers Injuries

  • David Njoku
    TE

    Njoku is out with knee

    Out

  • KeAndre Lambert-Smith
    WR

    Lambert-Smith is out with hamstring

    Out

See more NFL Injuries Right Arrow
Player Stats
  • passing yards
    Justin Herbert logo
    Justin Herbert
    3727
    pyds
  • passing touchdowns
    Justin Herbert logo
    Justin Herbert
    26
    ptd
  • rushing yards
    Kimani Vidal logo
    Kimani Vidal
    643
    ryds
  • rushing touchdowns
    Omarion Hampton logo
    Omarion Hampton
    4
    rtd
Depth Charts
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Starter2ND3RD4TH
QBJustin HerbertTrey LanceDJ Uiagalelei
RBOmarion HamptonNajee HarrisKimani VidalHassan HaskinsJaret Patterson
WRLadd McConkeyDerius DavisLuke Grimm
TEWill DisslyTyler ConklinOronde GadsdenTucker FiskThomas Yassmin
LTJoe AltJamaree Salyer
LGZion JohnsonBranson Taylor
CBradley BozemanAndre JamesJosh Kaltenberger
RGMekhi Becton
RTTrey Pipkins
RDEDa'Shawn HandJustin EboigbeScott Matlock
LCBDonte JacksonDeane Leonard
SSDerwin JamesTony JeffersonRJ Mickens
FSElijah MoldenKendall Williamson
RCBCam HartNikko ReedBenjamin St-JusteEric Rogers
PJK Scott
HJK Scott
PRDerius DavisLadd McConkeyKeAndre Lambert-Smith
KRDerius DavisHassan HaskinsKeAndre Lambert-Smith
LSJosh Harris
FBScott Matlock
RILBDaiyan HenleyJunior ColsonEmany JohnsonMarlowe Wax
RWRKeenan AllenQuentin JohnstonDalevon Campbell
LOLBTuli TuipulotuKyle Kennard
LWRTre' HarrisKeAndre Lambert-SmithJaQuae Jackson
ROLBKhalil MackBud DupreeGarmon Randolph
LILBDenzel PerrymanTroy DyeDel'Shawn Phillips
NTTeair TartJamaree CaldwellTeRah Edwards
NBTarheeb Still
DTOtito Ogbonnia
KCameron Dicker

49ers vs. Chargers Odds Comparison

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49ers at Chargers Team Totals

MatchupOverUnder
49ers
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N/A
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Chargers
0-0
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