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49ers vs. Chargers Odds & Betting Predictions - August 21, 2026

49ers at Chargers

2:00 am • NFL Network

San Francisco 49ers

0-1
@

Los Angeles Chargers

1-0

49ers at Chargers Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
49ers
0-1
+1.5
+1.5-115
o39.5-105
+105
Chargers
1-0
u39.5
-1.5-110
u39.5-118
-125
location pinFriday 2:00 a.m.
August 21, 2026
SoFi StadiumInglewood
thermometer image76°Fahrenheit
rain image0%Rain
wind image5Wind

49ers vs. Chargers Props

Prop Projections

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Prop Odds Comparison

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Line Movement Tracker

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49ers vs. Chargers Public Betting Percentages

Away Logo

49ers

Public

Home Logo

Chargers

100%

Bets%

0%

Money%

NFL Public Betting Right Arrow

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Chargers		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Chargers		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Chargers		N/AN/AN/AN/AN/A
49ers		N/AN/AN/AN/AN/A

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Aug 14th@HOUW 27-7+1.5 WU 38.5LAC -103
Jan 12th@NEL 3-16+3.5 LU 45.5NE +159
Jan 4th@DENL 3-19+15.5 LU 37.5DEN +908
Dec 27thHOUL 16-20-1.5 LU 41HOU -119
Dec 21st@DALW 34-17+1.5 WO 50.5LAC -102
Player Stats
  • passing yards
    Justin Herbert logo
    Justin Herbert
    3727
    pyds
  • passing touchdowns
    Justin Herbert logo
    Justin Herbert
    26
    ptd
  • rushing yards
    Kimani Vidal logo
    Kimani Vidal
    643
    ryds
  • rushing touchdowns
    Omarion Hampton logo
    Omarion Hampton
    4
    rtd
Depth Charts
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Starter2ND3RD4TH
QBJustin HerbertTrey LanceDJ Uiagalelei
RBOmarion HamptonNajee HarrisKimani VidalHassan HaskinsJaret Patterson
WRLadd McConkeyDerius DavisLuke Grimm
TEWill DisslyTyler ConklinOronde GadsdenTucker FiskThomas Yassmin
LTJoe AltJamaree Salyer
LGZion JohnsonBranson Taylor
CBradley BozemanAndre JamesJosh Kaltenberger
RGMekhi Becton
RTTrey Pipkins
RDEDa'Shawn HandJustin EboigbeScott Matlock
LCBDonte JacksonDeane Leonard
SSDerwin JamesTony JeffersonRJ Mickens
FSElijah MoldenKendall Williamson
RCBCam HartNikko ReedBenjamin St-JusteEric Rogers
PJK Scott
HJK Scott
PRDerius DavisLadd McConkeyKeAndre Lambert-Smith
KRDerius DavisHassan HaskinsKeAndre Lambert-Smith
LSJosh Harris
FBScott Matlock
RILBDaiyan HenleyJunior ColsonEmany JohnsonMarlowe Wax
RWRKeenan AllenQuentin JohnstonDalevon Campbell
LOLBTuli TuipulotuKyle Kennard
LWRTre' HarrisKeAndre Lambert-SmithJaQuae Jackson
ROLBKhalil MackBud DupreeGarmon Randolph
LILBDenzel PerrymanTroy DyeDel'Shawn Phillips
NTTeair TartJamaree CaldwellTeRah Edwards
NBTarheeb Still
DTOtito Ogbonnia
KCameron Dicker

49ers vs. Chargers Odds Comparison

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49ers at Chargers Team Totals

MatchupOverUnder
49ers
0-1
N/A
N/A
Chargers
1-0
N/A
N/A