It should be a high-flying shootout tonight, and that makes Lions vs. Bills best bets on Thursday Night Football (8:15 p.m. ET, Prime Video) a perfect place to get started with the Polymarket promo code. This welcome offer is easy to get started with: a $10 deposit unlocks a $50 trading bonus for the big game.
The Buffalo faithful will be a lot more rawkus than usual, as tonight begins a new chapter for the city as it shows off the polished Highmark Stadium for its first-ever regular-season NFL game. Both teams had down-to-the-wire finishes in Week 1, but Detroit is coming off an overtime finish that went down to the waning seconds. Now, the Lions have to travel into what is expected to be one of the most hostile environments in Buffalo's history. Add the Lions missing both safeties again, and we're in for a potentially historic performance from Josh Allen & Co.
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Lions vs. Bills Best Bets on Polymarket
Here are our three Lions vs. Bills best bets to use with the $50 bonus you get from the Polymarket promo code:
Bills -5.5 (50¢)
Buffalo rattled off an impressive win in the season opener, a 36-31 shootout against a phenomenal Houston defense. Meanwhile, Detroit needed every second to hold off a valiant effort by New Orleans in a 31-30. Now, that same Lions team has to hit the road on a short week as the Bills open their brand-new stadium. Good luck with all that! Detroit is still missing its two starting safeties, and you have to wonder how much head coach Dan Campbell will push his bellcow RB Jahmyr Gibbs in Week 2 with only three full rest days. This probably leads the Lions to take more risks, which will inevitably lead to turnovers.

Over 53.5 Points (56¢)
The official total is 54.5 points, but buying down to 53.5 puts us in a much better position to hit a common score like 30-24 or 37-17. I don't see the Bills having any issue scoring points, considering how Tyler Shough carved up this Lions' secondary in the second half of their narrow escape in Week 1. Buffalo's offense looked incredible in Houston last week, and that momentum should carry over on the short week. Detroit will likely need to turn it up in the second half, just like New Orleans did to them on Sunday. Some of the NFL's best offensive players will be on the field tonight, so this is shaping up nicely for the entertainment value.
DJ Moore: Anytime Touchdown (34¢)
Allen will certainly want to keep his #1 target happy and make it feel like coming to Buffalo was worth it. Of course it was! But this is a phenomenal matchup that Moore can take advantage of. Although he didn't get in the end zone last week, Saints WR Chris Olave torched the Lions' secondary with 10 catches (on 13 targets) for 162 yards, and much of that came while the game was still close. All in all, the Lions' secondary doesn't have the horses to match any WR1 right now, and Moore will take advantage of that tonight.
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