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Phillies vs. Cubs Odds & Betting Predictions - April 22, 2026

Phillies at Cubs

11:40 pm • NBCS-PH+

Philadelphia Phillies

8-15
@

Chicago Cubs

14-9
Starting Pitchers
pitcherteameraw-l
Matthew Boyd logoM.BoydChicago Cubs logo6.751-1
Kyle Backhus logoK.BackhusPhiladelphia Phillies logo5.400-0

Phillies at Cubs Odds

Spread, Total, Moneyline

MatchupOpenSpreadTotalMoneyline
Phillies
8-15
+1.5
+1.5-135
o7.5-110
+165
Cubs
14-9
u8
-1.5+114
u7.5-110
-191
location pinWednesday 11:40 p.m.
April 22, 2026
Wrigley FieldChicago
thermometer image53°Fahrenheit
rain image0%Rain
wind image7Wind
Phillies vs. Cubs Expert Picks
OldSchool0909
Last 30d: 150-159-0 (+15.2u)
PHI +166
1u
Picks Office
Picks Office
Last 30d: 196-182-7 (+1.7u)
Under 8-120
1u
Join Discord. All picks posted before 8am https://discord.gg/HjKxYKdSUy
Top Shelf Action 🥃
Top Shelf Action 🥃
Last 30d: 279-249-8 (+13.1u)
A.Garcia o0.5 HR+700
0.13u
#EV Circa +525
Wags Wins
Wags Wins
Last 30d: 210-239-2 (-16.3u)
Over 8+100
1u
Scott Rickenbach
Scott Rickenbach
Last 30d: 92-116-4 (-31.2u)
PHI +160
1u
Frank Ammirante
Frank Ammirante
Last 30d: 257-302-14 (-5.2u)
Under 4.5 (F5)-125
1.25u
Ryan Minion
Ryan Minion
Last 30d: 232-298-4 (-13.0u)
A.Bohm o1.5 Hits + Runs + RBIs+100
$1.00
D.Swanson o1.5 Hits + Runs + RBIs+112
$1.00
Frank Ammirante
Frank Ammirante
Last 30d: 257-302-14 (-5.2u)
Under 8.5-112
1.12u

Phillies vs. Cubs Previews & Analysis

  • Phillies vs Cubs: Strikeout Prop article feature image

    Phillies vs Cubs: Strikeout Prop

    Tanner McGrath•
    Apr 22, 2026 UTC
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Prop Odds Comparison

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Line Movement Tracker

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Phillies vs. Cubs Public Betting Percentages

Away Logo

Phillies

Public

Home Logo

Cubs

22%

Bets%

78%

Money%

MLB Public Betting Right Arrow

Betting Trends

  • Cubs are 5-0 in their last 5 games.
  • Cubs are 4-1 in their last 5 games against the spread
  • Cubs are 4-5 in their road games against the spread
  • The totals have gone OVER in 2 of Cubs' last 5 games
  • The totals have gone OVER in 7 of Cubs' 14 last games at home

Matchup History

Against the Spread (ATS) History

overallhomeawayfavoriteunderdog
Cubs		11-127-74-57-94-3
Phillies		4-192-132-64-150-4

Over/Under History

overallhome o/uaway o/ufavorite o/uunderdog o/u
Cubs		13-107-76-38-85-2
Phillies		11-11-18-6-13-510-8-11-3

Straight-Up (ML) History

overallhomeawayfavoriteunderdog
Cubs		14-99-55-410-64-3
Phillies		8-155-103-58-110-4

Last 5 Matchups

dateopponentscorespreadover/undermoneyline
Apr 21stPHIW 7-4-1.5 WO 8.5CHC -128
Apr 20thPHIW 5-1+1.5 WU 7.5CHC -114
Apr 19thNYMW 2-1-1.5 LU 8CHC -139
Apr 18thNYMW 4-2+1.5 WU 8.5CHC -118
Apr 17thNYMW 12-4-1.5 WO 10CHC -152

Cubs vs. Phillies Injury Updates

Cubs Injuries

  • Tyler Austin
    1B

    Austin is out with knee

    Out

  • Justin Steele
    SP

    Steele is out with elbow

    Out

  • Jordan Wicks
    SP

    Wicks is out with arm

    Out

Phillies Injuries

  • Zack Wheeler
    SP

    Wheeler is out with shoulder

    Out

  • Max Lazar
    RP

    Lazar is out with oblique

    Out

  • Andrew Painter
    SP

    Andrew Painter was seen walking out to bullpen, he won't start but could be available in relief.

    Questionable

  • Steward Berroa
    RF

    Berroa is out with shoulder

    Out

See more MLB Injuries Right Arrow
Phillies vs. Cubs Starting Lineups
Phillies Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Kyle Backhus logoLK.Backhus, P0-05.401.20012.15
HITTERSAVGOBPSLGHR
Kyle Schwarber logo1K.Schwarber, LF.217.363.5548
Trea Turner logo2T.Turner, SS.234.294.3402
Bryce Harper logo3B.Harper, DH.274.365.5365
Felix Reyes logo4F.Reyes, 1B.286.286.7141
Adolis Garcia logo5A.Garcia, RF.210.301.3332
Alec Bohm logo6A.Bohm, 3B.128.205.1791
Edmundo Sosa logo7E.Sosa, 2B.219.265.3751
Justin Crawford logo8J.Crawford, CF.283.377.4000
Rafael Marchan logo9R.Marchan, C.065.094.1611
Cubs Starting Lineup
Projected
PITCHERW-LERAWHIPK/9
Matthew Boyd logoLM.Boyd, P1-16.751.17916.39
HITTERSAVGOBPSLGHR
Nico Hoerner logo1N.Hoerner, 2B.326.402.5334
Alex Bregman logo2A.Bregman, 3B.245.327.3402
Ian Happ logo3I.Happ, LF.244.367.5126
Seiya Suzuki logo4S.Suzuki, RF.256.396.3591
Michael Busch logo5M.Busch, 1B.173.269.1980
Dansby Swanson logo6D.Swanson, SS.187.337.4005
Moises Ballesteros logo7M.Ballesteros, DH.378.431.6003
Miguel Amaya logo8M.Amaya, C.243.364.3511
Pete Crow-Armstrong logo9P.Crow-Armstrong, CF.225.281.3031

Phillies vs. Cubs Odds Comparison

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Phillies at Cubs Team Totals

MatchupOverUnder
Phillies
8-15
N/A
N/A
Cubs
14-9
N/A
N/A