Two games stand out above the rest to warrant trading MLB predictions today. Tampa Bay and New York close out a day-night doubleheader in the Bronx at 7:05 p.m. ET on Prime Video, and Los Angeles hosts San Diego in a duel between two excellent pitchers.
Read on to see my best MLB predictions today for Rays vs. Yankees and Padres vs. Dodgers. My picks are built off starter form, lineup availability and live pricing on Novig. Speaking of Novig, sign up with Novig promo code ACTION ACTION, deposit $10 and net $25 in trade credits before first pitch to fund your trades on MLB prediction markets.
How I Build My MLB Predictions Today
Here are some general rules of thumb I follow and trends I keep in mind when trading MLB predictions today, Tuesday, Sept. 22, 2026:
- I value starter command and WHIP above overall season record
- I keep an eye on lineup news, since locked-in playoff teams may rest players
- Bullpen usage is another focial point, as it swings the Rays-Yankees doubleheader nightcap
- I price value of MLB odds against my own projected number, not the consensus
Rays vs. Yankees MLB Predictions Today (7:05 p.m. ET, Prime Video)
| Key Input | Detail |
|---|---|
| Starters | Drew Rasmussen (2.81 ERA) vs. Max Fried (2.63 ERA, 0.98 WHIP) |
| Moneyline | Rays win YES (46%) Yankees win YES (55%) |
| Totals | 6.5 runs |
- My Rays vs. Yankees prediction: Under 6.5 total runs
Here is why a low scoring game leads my list of MLB predictions today:
- Rasmussen and Fried each hold a WHIP under 1.00, and each allows one earned run or fewer in most recent outings.
- Aaron Judge sits on the 10 day injured list with a right calf strain, which removes New York's most dangerous bat.
- Cooler Bronx evening air trims carry to the corners on long balls.
Padres vs. Dodgers MLB Predictions Today (10:10 p.m. ET, TBS)
| Key Input | Detail |
|---|---|
| Starters | Michael King (3.03 ERA, 1.16 WHIP) vs. Yoshinobu Yamamoto (2.51 ERA, 0.87 WHIP) |
| Moneyline | Padres win YES 47%, Dodgers win YES 55% |
| Totals | 8 runs |
- My Padres vs. Dodgers prediction: Dodgers, first five innings moneyline (56%)
The second of my MLB predictions today to trade on prediciton markets like Novig is the Dodgers to win the first five innings:
- Yamamoto owns the clear command and baserunner edge in this matchup
- Los Angeles hitters post a 46% quality at bat rate, tied for the MLB lead.
- San Diego relievers strike out 29% of hitters in close and late spots, second best in the majors, meaning they claw back after the starters exit. That bullpen gap makes the full game price less attractive than the first five.
If you like my analysis of the two marquee MLB games this evening, sign up with Novig promo code ACTION from Action Network and trade these picks.
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Register now with a new Novig account, deposit $10, and see $25 in trade credits hit your account instantly. Novig is one of the many prediction market apps where you trade against other users rather than a house line. Here is the most important information to note before signing up:
- Welcome bonus: Deposit $10, get $25 in trade credits
- Bonus payout: Five individual $5 trade credits
- Who qualifies? New traders aged 21 and older
- Live states? AK, AR, FL, GA, HI, IL, IN, IA, KS, KY, ME, MA, MN, MO, NE, NH, NC, ND, OH, OK, OR, SC, SD, TX, VT, VA, DC, WI, WY
Sign up using the Novig promo code ACTION and put your credits behind my MLB predictions today. Now is an exciting time to capitalize on this offer with the final week of the regular season upon us before the postseason.
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