Cubs vs. Athletics Odds & Betting Predictions - March 21, 2026

Cubs at Athletics

1:10 am • MARQ

Chicago Cubs

@

Athletics

pitcher		team	era	w-l

MatchupOpenSpreadTotalMoneyline
Cubs 11-14	N/A	N/A	N/A
Athletics 13-14	N/A	N/A	N/A

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Saturday 1:10 a.m.

March 21, 2026

HoHoKam ParkMesa

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101°Fahrenheit

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MLB Public Betting

Athletics are 2-3 in their last 5 games.
Athletics are 2-3 in their last 5 games against the spread
Athletics are 47-34 in their road games against the spread
The totals have gone OVER in 2 of Athletics' last 5 games
The totals have gone OVER in 40 of Athletics' 81 last games at home

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Athletics	86-76	39-42	47-34	14-24	70-50
Cubs	78-84	39-42	39-42	55-60	22-24

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Athletics	77-77-8	40-39-2	37-38-6	14-22-2	61-53-6
Cubs	74-78-10	40-36-5	34-42-5	52-56-7	22-21-3

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Athletics	76-86	36-45	40-41	17-21	56-64
Cubs	92-70	50-31	42-39	73-42	18-28

date	opponent	score	spread	over/under	moneyline
Mar 17th	@CWS	L 4-6	+1.5 L	U 12.5	CWS +100
Mar 16th	LAA	W 3-0	-1.5 W	U 11.5	ATH -160
Mar 15th	@CLE	L 6-12	+1.5 L	O 11.5	CLE +125
Mar 14th	KC	W 12-1	-1.5 W	O 11.5	ATH -168
Mar 13th	@MIL	W 13-4	-	-	-

Luis Medina
SP
Medina is out with elbow
Out

Justin Steele
SP
Steele is out for season with elbow
Out for Season

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MatchupOverUnder
Cubs 11-14	N/A	N/A
Athletics 13-14	N/A	N/A