The Oklahoma State Cowboys take on the Arizona Wildcats in Tucson, Arizona. Kickoff is set for 3 p.m. ET on TNT.
Arizona is favored by -20.5 points on the spread with a moneyline of -1200. The total is set at 55.5 points.
Here’s my Oklahoma State vs. Arizona prediction and college football picks for Saturday, October 4, 2025.
Oklahoma State vs Arizona Prediction
- Oklahoma State vs. Arizona Pick: Arizona -20 or Better
My Arizona vs. Oklahoma State best bet is on the Wildcats to cover the spread. Find the best line available on our live NCAAF odds page.
Oklahoma State vs Arizona Odds
| OK State Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
+20.5 -110 | 55.5 -110o / -110u | +750 |
| Arizona Odds | ||
|---|---|---|
| Spread | Total | Moneyline |
-20.5 -110 | 55.5 -110o / -110u | -1200 |
- Oklahoma State vs Arizona point spread: Arizona -20.5
- Oklahoma State vs Arizona over/under: 55.5 points
- Oklahoma State vs Arizona moneyline: Oklahoma State +750, Arizona -1200
Oklahoma State vs Arizona Preview
Oklahoma State is a mess.
Its opponent-adjusted metrics on both sides of the ball almost appear to be a mistake. This is the worst power conference team by a magnificent margin.
How bad is it from a power ratings perspective? As of right now, I'd have lowly Western Michigan favored on a neutral field over the Pokes, who recently got dominated on their home field by Tulsa.
There's nothing to like about this team. The quarterback play is putrid behind an offensive line missing its best player, and the defense can't stop a nose bleed.
So, is this the bottom? Maybe not. After firing head coach Mike Gundy last week, Oklahoma State fired defensive coordinator Todd Grantham on Sunday. So, who will take over as the interim in his place? Clint Bowen, whom Gundy brought in as an offensive quality control coach in the offseason after Bowen spent the past four years at the high school level.
I also wouldn't be surprised to see a few more players enter the portal.
Oklahoma State lacks direction on defense, while its offense operates with tempo, showing no discernible strengths.
That's a recipe for a complete blowout in the desert against what should be an angry Arizona bunch coming off a blowout loss in Ames.
The Wildcats got burned by allowing too many explosive passing plays against the Cyclones, who also exploited them over the middle of the field. Well, that shouldn't be much of an issue against quarterback Zane Flores, who really struggles to throw between the hashes and has completed just three of his 21 (14.3%) deep balls this season.
Meanwhile, Arizona should find success doing whatever it chooses while on offense. Last week, the wide receivers struggled to get separation against the Iowa State secondary. That won't be an issue this week. And the ground game should really get going on early downs, making life much easier for quarterback Noah Fifita.
Arizona's special teams are a bit of a mess at the moment, but that shouldn't matter in this one.
Give me the Wildcats to bounce back in a big way by at least three touchdowns against the corpse of Oklahoma State.
Pick: Arizona -20 or Better
