49ers vs. Cardinals NFL Odds, Betting System Pick: Spread Prediction for Sunday’s Week 5 Game

49ers vs. Cardinals NFL Odds, Betting System Pick: Spread Prediction for Sunday’s Week 5 Game article feature image
Credit:

Photo by Michael Zagaris/San Francisco 49ers/Getty Images. Pictured: Samson Ebukam #56, D.J. Jones #93 and Kentavius Street #95 of the San Francisco 49ers

49ers vs. Cardinals NFL Odds

49ers Odds +5
Cardinals Odds -5
Over/Under 48.5
Date Sunday, Oct. 10
Time 4:25 p.m. ET
TV FOX

*Odds as of Saturday morning

With a 4-0 start to the season, the Arizona Cardinals have vaulted themselves into the Super Bowl picture.

Arizona’s 16-1 odds to win Super Bowl 52 at DraftKings Sportsbook ranks eighth on the board, and a win over San Francisco on Sunday will keep the Cardinals undefeated on the season and one game clear of the Rams in the NFC West.

On the other hand, San Francisco is floundering at 2-2 on the season and dealing with an injury to starting quarterback Jimmy Garoppolo.

Luckily for the 49ers, they have rookie Trey Lance who will start in place of the injured Jimmy G. against Arizona.

So what is the smart way to bet 49ers vs. Cardinals on Sunday?

Should bettors bank on the Cards to continue rolling, or is five points too many to give a talented team at home?

Or is the 49ers vs. Cardinals total quietly becoming the savvy play?

Using our NFL PRO Betting Systems, let’s answer those very questions.

49ers vs. Cardinals NFL Betting Prediction