The 49ers and Rams kicks off at 8:35 p.m. ET on Netflix in the first NFL regular season game in Australia, and I have all the best 49ers vs. Rams bets today for you to wager on. Note that the Rams enter today as a 3.5-point favorite with a totals market set at 48.5 points.
Below you get my three best 49ers vs. Rams bets today with the reasoning behind each one. Price it all after signing up with the BetMGM bonus code TOPACTION, which returns your first bet's stake in bonus bets if it results in a loss, up to $1,500.
Best 49ers vs. Rams Bets Today: Rams -3.5 (-110)
The Los Angeles Rams built the most star-studded defense in football this offseason, trading for reigning Defensive Player of the Year Myles Garrett, and bringing back Aaron Donald. Even though Donald is not suiting up tonight, their defense is one of the biggest reasons I like this pick:
- Brock Purdy thrives on clean pockets and rhythm throws, and the Rams' pass rush figures to erase both
- The Rams went 9-3 against the spread when being favorites of 3.5 points or more last season
- There is a big talent gap between Los Angeles (who enter as the NFC West favorite, and San Francisco (who carry more roster questions)
Next 49ers vs. Rams Prediction: Under 48.5 Total Points (-110)
Next up on my list of best 49ers vs. Rams bets today is a more defensive-minded game that lacks a lot of scoring. The San Francisco 49ers landed in Melbourne on Friday and practiced through the weekend. The Rams flew in far later on a 17-hour trip. Two jet lagged offenses on an unfamiliar surface is a recipe for punts and stalled drives:
- Neutral site openers historically trend under the total
- As mentioned earlier, Los Angeles has a loaded defense, while San Francisco adds Dre Greenlaw back to a core of Fred Warner and Nick Bosa
- Kyle Shanahan and Sean McVay know each other as well as any coaches in the league, and that familiarity makes trick plays and new wrinkles offensively more difficult to execute
Final 49ers vs. Rams Pick: Christian McCaffrey Anytime Touchdown (-110)
Round out betting on my best 49ers vs. Rams bets today with our NFL Week 1 betting promos from Action Network. San Francisco's path to pulling off the upset runs through dominating possession. Because of this, I expect there to be more than enough volume for McCaffrey to strike pay-dirt.
- Kyle Shanahan showed last year he had no quarrels feeding McCaffrey the ball heavily inside the 10
- George Kittle playing pulls safety attention on these types of looks
- This prop correlates cleanly with my Under pick above, as a McCaffrey heavy script drains the clock
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