49ers vs Rams Odds & Live Scores - September 10, 2026

49ers at Rams

12:35 am • Netflix

San Francisco 49ers

Los Angeles Rams

MatchupOpenSpreadTotalMoneyline
49ers 0-0	+2.5	+3.5-106	o48.5-108	+166
Rams 0-0	u49.5	-3.5-114	u48.5-110	-200

Friday 12:35 a.m.

September 11, 2026

LA -3.5-118

@Stuckey2 https://podcasts.apple.com/us/podcast/nfl-week-1-betting-preview/id1004530793?i=1000788564665

D.Samuel Anytime TD Scorer Yes+350

0.5u

D.Adams Anytime TD Scorer Yes+135

0.75u

B.Corum o43.5 Rush Yds-110

$1.00

Corum is the 1b to Williams 1a and had 44+ rushing yards in 9 of 13 games after last year's week eight bye

D.Stribling o3.5 Recs+134

$1.00

Coaches have been praising the rookie, and he'll lineup in the slot, meaning plenty of quick ball from Brock Purdy who'll have the Rams' defense upon him.

C.McCaffrey o4.5 Recs-102

$1.00

CMC had 5+ receptions in 15 of 19 games last season, including both gams against the Rams

SF +3.5-108

@KendraMiddleton_ @BKPicks https://open.spotify.com/episode/3Mq6hZT1xRt2mUhl18cQvb?si=GcCrvo8NSWSs3q7nT3Jbcw&utm_source=copy-link

D.Adams Anytime TD Scorer Yes+130

0.77u

@BKPicks https://open.spotify.com/episode/3Mq6hZT1xRt2mUhl18cQvb?si=GcCrvo8NSWSs3q7nT3Jbcw&utm_source=copy-link

C.McCaffrey o4.5 Recs-111

@BKPicks https://open.spotify.com/episode/3Mq6hZT1xRt2mUhl18cQvb?si=GcCrvo8NSWSs3q7nT3Jbcw&utm_source=copy-link

LA -3.5-112

0.45u

SF +3.5-110

0.25u

D.Adams Anytime TD Scorer Yes+130

0.25u

C.McCaffrey u13.5 Longest Rush-102

1.02u

SF +3.5-110

NFL POD

SF +4.5-110

1.1u

SF +3.5-110

2.2u

D.Adams Anytime TD Scorer Yes+135

0.5u

Under 48.5-105

0.53u

Under 49.5-110

Open Air Unders: Divisional Drift Overall: 395-286-8,58% (ROI:12%) Season:19-12-0,61% (ROI:17%) Open Air Unders: Divisional Drift - copy Overall: 280-197-4,59% (ROI:14%) Season:12-9-0,57% (ROI:10%) #TSA

LA -2.5-110

1.1u

LA -2.5-110

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NFL Public Betting

Against the Spread (ATS) History

	overall	home	away	favorite	underdog
Rams	N/A	N/A	N/A	N/A	N/A
49ers	N/A	N/A	N/A	N/A	N/A

Over/Under History

	overall	home o/u	away o/u	favorite o/u	underdog o/u
Rams	N/A	N/A	N/A	N/A	N/A
49ers	N/A	N/A	N/A	N/A	N/A

Straight-Up (ML) History

	overall	home	away	favorite	underdog
Rams	N/A	N/A	N/A	N/A	N/A
49ers	N/A	N/A	N/A	N/A	N/A

date	opponent	score	spread	over/under	moneyline
Aug 28th	@LAC	W 20-18	+3.5 W	U 38	LA +145
Aug 22nd	NO	W 34-0	+1.5 W	U 38.5	LA +104
Aug 15th	@KC	W 20-12	+1.5 W	U 36.5	LA +106
Jan 25th	@SEA	L 27-31	+2.5 L	O 45.5	SEA +120
Jan 18th	@CHI	W 20-17	-3.5 L	U 49.5	LA -205

passing yards
Matthew Stafford
4707
pyds
passing touchdowns
Matthew Stafford
46
ptd
rushing yards
Kyren Williams
1252
ryds
rushing touchdowns
Kyren Williams
10
rtd

	Starter	2ND	3RD	4TH
QB	Matthew Stafford	Stetson Bennett	Ty Simpson	Matthew Caldwell
RB	Kyren Williams	Blake Corum	Ronnie Rivers	Dean Connors
WR	Jordan Whittington	Xavier Smith	Brennan Presley	Alex Bachman
TE	Colby Parkinson	Tyler Higbee	Terrance Ferguson	Max Klare
LT	Alaric Jackson	David Quessenberry	Alex Bachman
LG	Steve Avila	Justin Dedich	Austin Blaske	Bill Murray
C	Coleman Shelton	Dylan McMahon
RG	Kevin Dotson	Beaux Limmer
RT	Warren McClendon	Keagen Trost	Blake Hance
LDE	Braden Fiske	Ty Hamilton	Larrell Murchison
LCB	Jaylen Watson	Cam Lampkin
SS	Kam Curl	Jaylen McCollough	Nick Andersen
FS	Kamren Kinchens	Tanner Ingle	Nick Andersen
RCB	Trent McDuffie	Emmanuel Forbes
P	Ethan Evans	Jack Bouwmeester
H	Ethan Evans	Jack Bouwmeester
PR	Xavier Smith	Kyren Williams
KR	Ronnie Rivers	Jordan Whittington	Brennan Presley
LS	Joe Cardona
LILB	Nate Landman	Shaun Dolac	Elias Neal
DT	Kobie Turner	Tyler Davis
NT	Poona Ford	Bill Norton
K	Harrison Mevis	Ethan Evans
ROLB	Myles Garrett	Desjuan Johnson	Darryl Peterson
LWR	Davante Adams	Konata Mumpfield
RILB	Omar Speights	Grant Stuard
NB	Quentin Lake	Josh Wallace	Nyzier Fourqurean
RWR	Puka Nacua	CJ Daniels
LOLB	Byron Young	Josaiah Stewart	Keir Thomas	Wesley Bailey

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MatchupOverUnder
49ers 0-0	N/A	N/A
Rams 0-0	N/A	N/A

49ers vs. Rams Odds & Betting Predictions - September 11, 2026

49ers at Rams

San Francisco 49ers

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49ers vs. Rams Previews & Analysis

Koerner's Week 1 Pick'em & Confidence Rankings

NFL Anytime Touchdown Machine: Live TD Odds & Trends

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NFL Betting Primer: Trends, Stats, Systems for Every Game

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