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With 10 days to work with, you've come to the right place at one of the best sports betting sites. In addition to the CFB Week 3 games on Friday and Saturday, NFL Week 2 is back in action this Sunday with Vikings vs. Bears (1 p.m. ET, FOX), Cowboys at Commanders (4:25 p.m. ET, FOX), and the Colts vs. Chiefs (8:20 p.m. ET, NBC) primetime matchup.
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Every account in eligible states (listed above) qualifies for one welcome promotion; bonus bets hold no cash value, and a winning bonus bet returns the profit without the stake. That structure rewards straight sides over long-shot parlays, which makes a single-game spread like the one anchoring our Lions vs. Bills predictions an ideal home for the daily token.
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BetMGM NFL Odds: Lions vs. Bills Preview & Prediction
| Market | Detroit Lions | Buffalo Bills |
|---|---|---|
| Moneyline | +210 | -250 |
| Spread | +5.5 (-105) | -5.5 (-105) |
| Total | Over 55 Points (-110) | Under 55 Points (-108) |
Buffalo christens the new Highmark Stadium at 8:15 p.m. ET on Prime Video, and the Bills arrive 1-0 after stacking 36 points and 7.9 yards per play on the road in Houston. Josh Allen looked like the same MVP-caliber problem defensive coordinators lose sleep over, carving up a Texans unit most people trusted coming into the season. Detroit sits 1-0 as well, though a 31-30 overtime escape against New Orleans turned on a stuffed two-point conversion rather than any kind of complete performance. Stack a short week, a road trip, and the loudest new building in football on top of that, and the spot leans firmly toward the home team in our Lions vs. Bills predictions.
The injury report settles this one. Detroit rules out starting RT Blake Miller with a knee issue and starting LG Christian Mahogany with a hip problem, which shoves two backups into a prime-time road opener on three days of preparation. Buffalo's interior rush feasts on exactly that kind of patchwork protection, and Ed Oliver lines up across from a guard making his first meaningful start of the year. CB D.J. Reed also carries a questionable tag with a foot injury, thinning an already-injured secondary that already faces a passing attack averaging more than eight yards a snap.
The Bills, by contrast, file a clean report, listing only safety Cole Bishop, running back Ty Johnson, and defensive lineman T.J. Sanders as questionable. Jahmyr Gibbs keeps Detroit inside the number for a half because talent travels, but the Lions need roughly 30 dropbacks behind a compromised line to stay there, and that math breaks down late.
Lions vs. Bills Prediction: Bills -5.5 (-105) + Over 53.5 Points (-140)
If you like our content and picks, sign up with the BetMGM bonus code TANGET2, claim your $1,000 in No Sweat Tokens, and put this one to good use by circling the wagons with the Bills.
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21+. Gambling problem? Call 1-800-GAMBLER or 1-800-MY-RESET. Offer available in MI, NJ, PA, WV. Please Gamble Responsibly. Subject to eligibility requirements. Bonus bets are non-withdrawable. In partnership with Kansas Crossing Casino and Hotel. This promotional offer is not available in MS, NY, NV, ON, or PR. Visit BetMGM.com for Terms & Conditions.
